Severe degenerative aortic stenosis with preserved ejection fraction does not change adipokines serum levels

Mizia-Stec, Katarzyna; Bochenek, Tomasz; Kusz, Błażej; Mizia‐Szubryt, Magdalena; Sikora-Puz, A.; Gieszczyk-Strózik, Klaudia

doi:10.5603/cj.a2017.0135

Cited by 2 publications

(7 citation statements)

References 35 publications

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“…Most studies searched for associations between adiponectin serum level and mechanical and mechanistic aspects of AS, such as valve calcification, progression of native valve stenosis, degeneration of bioprosthetic valves, and LV remodeling. 20 , 21 , 22 , 23 , 24 Little is known about the ability of adiponectin to predict adverse outcome after TAVI due to severe aortic stenosis (AS).…”

Section: Discussionmentioning

confidence: 99%

“…These investigators selected patients who were younger than our cohort and often were surgical AVR candidates, so patient frailty was less of a concern. 20 , 21 , 22 …”

Section: Discussionmentioning

confidence: 99%

“…These investigators selected patients who were younger than our cohort and often were surgical AVR candidates, so patient frailty was less of a concern. [20][21][22] Our study differs from the aforementioned studies by the chosen endpoint and the variables, included in the multivariable model. Our…”

Section: Discussionmentioning

confidence: 99%

“…Prior investigators have considered the potential for adiponectin to prevent adverse events through proposed anti‐inflammatory actions in aortic stenosis 20–23 . The role of adiponectin to predict frailty per se was not considered.…”

Section: Discussionmentioning

confidence: 99%

“…The role of adiponectin to predict frailty per se was not considered. These investigators selected patients who were younger than our cohort and often were surgical AVR candidates, so patient frailty was less of a concern 20–22 …”

Section: Discussionmentioning

confidence: 99%

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Adiponectin serum level is an independent and incremental predictor of all‐cause mortality after transcatheter aortic valve replacement

Walpot

Herck

Collas

et al. 2022

Clinical Cardiology

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Background: Quantifiable biomarkers may be useful for a better risk and frailty assessment of patients referred for transcatheter aortic valve implantation (TAVI).Hypothesis: To determine if adiponectin serum concentration predicts all-cause mortality in patients undergoing TAVI.Methods: 77 consecutive patients, undergoing TAVI, were analyzed. The CT axial slices at the level of the fourth lumbar vertebra were used to measure the psoas muscle area, and its low-density muscle fraction (LDM (%)). To assess the operative risk, the STS (Society of Thoracic Surgeons Predicted Risk of Mortality) score, Log.Euroscore, and Euroscore II were determined. A clinical frailty assessment was performed. ELISA kits were used to measure adiponectin serum levels. We searched for a correlation between serum adiponectin concentration and all-cause mortality after TAVI. Results:The mean age was 80.8 ± 7.4 years. All-cause mortality occurred in 22 patients. The mean follow-up was 1779 days (range: 1572-1825 days). Compared with patients with the lowest adiponectin level, patients in the third tertile had a hazards ratio of all-cause mortality after TAVI of 4.155 (95% CI: 1.364-12.655) (p = .004). In the multivariable model, including STS score, vascular access of TAVI procedure, LDM (%), and adiponectin serum concentration, serum adiponectin level, and LDM(%) were independent predictors of all-cause mortality after TAVI (p = .178, .303, .042, and .017, respectively). Adiponectin level was a predictor of all-cause mortality in females and males (p = .012 and 0.024, respectively).

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Section: Discussionmentioning

confidence: 99%

“…These investigators selected patients who were younger than our cohort and often were surgical AVR candidates, so patient frailty was less of a concern. 20 , 21 , 22 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Adiponectin serum level is an independent and incremental predictor of all‐cause mortality after transcatheter aortic valve replacement

Walpot

Herck

Collas

et al. 2022

Clinical Cardiology

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Identification of leptin resistance in patients with coronary artery disease and heart defects

Gorbatovskaya,

Dyleva,

Belik

et al. 2023

Russ J Cardiol

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Aim. To compare the incidence of leptin resistance (LR) in patients with acute and chronic coronary artery disease (CAD) and patients with acquired heart defects (AHD).Material and methods. The study included 234 patients: 114 patients with acute myocardial infarction (MI) and 120 patients with chronic CAD. The comparison group consisted of 48 patients with degenerative non-rheumatic AHD — aortic stenosis (AS). The control group consisted of 40 healthy volunteers. On the 1st day of hospitalization, the concentration of leptin and leptin receptor was measured, and the free leptin index (FLI) was assessed. LR was recorded at leptin >6,45 ng/ ml and FLI >25. Statistical data processing was carried out using the software package Statistica 10.0 and SPSS 17.0 for Windows.Results. Initially, LR in MI, chronic CAD and non-coronary disease was revealed in 64%, 56,2% and 25%, respectively. Significant differences in the incidence of LR were observed between patients with MI and chronic CAD relative to patients with AHD (p=0,02 and p=0,03, respectively), while no differences were found between patients with coronary pathology (p=0,82). Equation of patients for body mass index (BMI) did not affect the incidence of LR. High incidence of LR remained for patients with acute and chronic CAD, and amounted to 63% and 57,3%, respectively, while for patients with AS — 25%.Conclusion. Patients with acute and chronic CAD are characterized by a high LR incidence, in contrast to patients with AHD. The number of LR cases in patients with coronary pathology did not depend on BMI values, which indicates possible alternative leptin sources contributing the development of hyperleptinemia. In addition, studying the mechanisms underlying the leptin receptor decrease in CAD is necessary for adequate leptin effects and the prevention of LR.

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Severe degenerative aortic stenosis with preserved ejection fraction does not change adipokines serum levels

Abstract: The presence of AS with preserved EF did not change the adipokine serum profile. Adipokines levels were modified by coexisting atherosclerosis but not the typical cardiovascular risk factors or the hemodynamic type of AS.

Cited by 2 publications

References 35 publications

Adiponectin serum level is an independent and incremental predictor of all‐cause mortality after transcatheter aortic valve replacement

Adiponectin serum level is an independent and incremental predictor of all‐cause mortality after transcatheter aortic valve replacement

Identification of leptin resistance in patients with coronary artery disease and heart defects

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