The Severe Respiratory Insufficiency Questionnaire for Subjects With COPD With Long-Term Oxygen Therapy

Abstract

BACKGROUND: Respiratory insufficiency in COPD may present as hypoxic and/or hypercapnic respiratory failure treated with long-term oxygen therapy (LTOT) and/or noninvasive ventilation (NIV) with LTOT. The Severe Respiratory Insufficiency Questionnaire (SRI) is a tool for the assessment of health-related quality of life (HRQOL) in subjects receiving NIV. However, it remains unclear whether the SRI is also capable of assessing and discriminating HRQOL in subjects receiving LTOT. METHODS: Stable subjects with COPD receiving LTOT or NIV ؉ LTOT (NIV) were prospectively recruited and completed the SRI, lung function tests, and blood gases. Confirmatory factor analysis for construct validity and internal consistency reliability were calculated. RESULTS: One hundred fifty-five subjects were included (113 LTOT, 42 NIV). The Cronbach ␣ coefficient of the 7 subscales ranged between 0.69 and 0.89 (LTOT) and between 0.79 and 0.93 (NIV), respectively. In both groups, confirmatory factor analysis revealed a one-factor model for the SRI summary scale; in 5 subscales, one-or 2-factor models could be established. Group differences in the SRI subsets were all P <.05 (except for physical functioning) with higher scores in subjects receiving NIV. CONCLUSIONS: The SRI showed high reliability and validity in subjects with COPD receiving LTOT. Subjects receiving LTOT had lower SRI scores, indicating a poorer HRQOL compared with subjects with established NIV and LTOT. Key words: quality of life; COPD; oxygen inhalation therapy; noninvasive ventilation; chronic air flow obstruction; severe respiratory insufficiency questionnaire (SRI). [Respir Care 2016;61(9):1186 -1191.

Comparison of Different Disease-Specific Health-Related Quality of Life Measurements in Patients with Long-Term Noninvasive Ventilation

“…Thus, structurally, the SRI would measure diversified health impairments more discriminatively than the MRF-26, although it may take more time to be administered. While the MRF was developed for patients with chronic respiratory failure irrespective of NIV, the SRI was primarily developed for patients with home NIV, and it recently was validated in patients with COPD receiving long-term oxygen therapy [18]. As a limitation of the present study, we did not compare responsiveness of the questionnaires, and this should be studied in the near future.…”

The Chinese version of the Severe Respiratory Insufficiency questionnaire for patients with chronic hypercapnic chronic obstructive pulmonary disease receiving non-invasive positive pressure ventilation

“… 14 28 In addition, we will assess the criterion validity of the SRI questionnaire in a future study. Recently, Windisch et al 28 showed that the SRI questionnaire was valid for patients with COPD receiving long-term home oxygen therapy. Therefore, in the near future, we plan to assess the reliability and validity of the Chinese version of the SRI questionnaire in patients with chronic hypercapnic respiratory failure who also have other diseases requiring long-term home mechanical ventilation and in patients with COPD receiving long-term home oxygen therapy.…”

Home noninvasive positive pressure ventilation with built-in software in stable hypercapnic COPD: a short-term prospective, multicenter, randomized, controlled trial

“…We did all blood gas measurements from arterialized capillary blood during spontaneous breathing, at least 1 h after the patients in the intervention group had switched from NPPV to spontaneous breathing. We assessed HRQL using the Severe Respiratory Insufficiency (SRI) Questionnaire14,15 and the COPD assessment test (CAT) as tools. We estimated pulmonary function, 6-min walk distance (6MWD), blood oxygen saturation, baseline dyspnea index (BDI), and transition dyspnea index (TDI) as previously specified 16–18.…”