The serum calcium level and its significance in hyperthyroidism: a prospective study

Gordon, Donald L.; Suvanich, Sunant; Erviti, Vivian; Schwartz, Maurice A.; Martinez, Charles J.

doi:10.1097/00000441-197407000-00004

Cited by 40 publications

(17 citation statements)

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“…It has been well known that hypercalcemia (1-3) due to direct stimulation of bone resorption by thyroid hormoneexcess (4) occurs in hyperthyroidism and its association is as frequent as 16 to 27% (1)(2)(3).…”

Section: Introductionmentioning

confidence: 99%

Development of Hypercalcemic Crisis in a Graves' Hyperthyroid Patient Associated with Central Diabetes Insipidus.

et al. 1995

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A 26-year-old man with Graves' hyperthyroidism associated with central diabetes insipidus (DI), initially showed hypercalcemic crisis. Initially, very low serum levels of intact parathyroid hormone (PTH) and 1,25-dihydroxy vitamin D3 and a moderate rise of serum C-terminal PTH related protein (C-PTHrP) were observed which strongly suggested a humoral hypercalcemia of malignancy due to PTHrP. However, the serum C-PTHrP level later became normal. Mild hyperprolactinemia, no responses of growth hormone (GH) to insulin-induced hypoglycemia despite a normal growth hormone releasing hormone (GRH) test and mild thickening of the pituitary stalk on magnetic resonance imaging were observed. Thus, an autoimmunenature of his central DI is considered; it is noteworthy that the serum C-PTHrPlevel may be elevated by renal failure in patients with hypercalcemia due to causes other than PTHrP. (Internal Medicine 34: 924-928, 1995)

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Section: Introductionmentioning

confidence: 99%

Development of Hypercalcemic Crisis in a Graves' Hyperthyroid Patient Associated with Central Diabetes Insipidus.

et al. 1995

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“…It has been attributed to an increased bone turnover although this may be an oversimplification as it does not explain why only a small proportion of patients develop hypercalcaemia, unless they are immobile or have developed renal insufficiency. The degree of thyroid overactivity does not seem to be a major factor as Gordon et al (1974) were unable to demonstrate a relationship between serum calcium and thyroid hormone concentrations in hyperthyroid patients. It has been proposed that a small proportion of patients have bone collagen which is particularly sensitive to thyroid hormone activity and it is this group who become hypercalcaemic (Askenasi and Demeester-Mirkine, 1975).…”

Section: Discussionmentioning

confidence: 82%

Control of hypercalcaemia in thyrotoxicosis

Jones¹,

Papapoulos²

1979

Postgraduate Medical Journal

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“…Hypercalcemia has been shown to occur in some patients with hyperthyroidism [27], and could be implicated as a possible cause of these symptoms. However, Gordon et al [28] found no such correlation between calcium levels and presence of vomiting or abdominal pain. In our three cases no patient had hypercalcemia.…”

Section: Discussionmentioning

confidence: 96%

Nausea and Vomiting as Major Presenting Symptoms of Thyrotoxicosis

et al. 2018

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Thyrotoxicosis has a variety of presentations which depend on its severity and duration, as well as the age of the patient. Nausea and vomiting as major presenting symptoms of thyrotoxicosis are rarely reported. We report three patients with nausea and vomiting as major presenting symptoms of thyrotoxicosis, where two of the patients were extensively investigated, and thyrotoxicosis was not suspected until late in the disease. In reporting these patients we aim at drawing attention to these forgotten symptoms of thyrotoxicosis, and particularly to emphasize that, at times nausea and vomiting may be the only presenting features of thyrotoxicosis, leading to considerable difficulty in diagnosis. Moreover, these case reports give further support to the contention that thyroid studies should be carried out in border indications than conventionally accepted.

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The serum calcium level and its significance in hyperthyroidism: a prospective study

Cited by 40 publications

References 0 publications

Development of Hypercalcemic Crisis in a Graves' Hyperthyroid Patient Associated with Central Diabetes Insipidus.

Development of Hypercalcemic Crisis in a Graves' Hyperthyroid Patient Associated with Central Diabetes Insipidus.

Control of hypercalcaemia in thyrotoxicosis

Nausea and Vomiting as Major Presenting Symptoms of Thyrotoxicosis

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