The serum alkaline phosphatase in chronic infiltrative disease of the liver

Ross, Richard S.; Iber, Frank L.; Harvey, A. McGehee

doi:10.1016/0002-9343(56)90099-7

Cited by 49 publications

(6 citation statements)

References 21 publications

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“…Some authors have shown raised serum-alkaline phosphatase (SAP) as suggestive of hepatic TB [4, 16], while others have shown presence of normal levels does not rule out hepatic TB [17]. In the present study, raised SAP was seen in 100% of tubercular group and 93% of the nontubercular group.…”

Section: Discussionsupporting

confidence: 42%

Tuberculosis as an Etiological Factor in Liver Abscess in Adults

Dey

Gautam

Venugopal

et al. 2016

Tuberculosis Research and Treatment

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Background. Tuberculosis of the liver without active pulmonary or miliary tuberculosis is considered as an uncommon diagnosis. The aim of the present study was to determine the etiological role of tuberculosis in adult patients presenting with features of liver abscess. Methods. A total of 40 patients with liver abscess were included in the study. The liver abscess aspirate was subjected to microscopy, culture, and polymerase chain reaction to determine the role of tuberculosis as an etiological factor in liver abscess. Results. Of the 40 patients enrolled, 25% (10/40) were diagnosed with having tubercular liver abscess. In a total of 40 specimens, 2.5% (1/40) were positive for acid fast bacilli by Ziehl-Neelsen method, while 10% (4/40) were positive for M. tuberculosis by culture using BACTEC 460 and the yield increased to 25% (10/40) by polymerase chain reaction for M. tuberculosis. Conclusion. 25% of the patients presenting with liver abscess had tubercular etiology without features of active pulmonary or miliary tuberculosis. Liver can act as the primary site of involvement in the absence of activity elsewhere in the body. Tuberculosis should be considered as an important differential diagnosis of liver abscess irrespective of evidence of active tuberculosis elsewhere in the body.

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Section: Discussionsupporting

confidence: 42%

Tuberculosis as an Etiological Factor in Liver Abscess in Adults

Dey

Gautam

Venugopal

et al. 2016

Tuberculosis Research and Treatment

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“…There is often a dissociation between serum bilirubin and serum alkaline phosphatase in various liver disorders (Burke, 1950). Metastatic cancer in the liver has long been known to produce hyperphosphatasia without hyperbilirubinaemia (Meranze, Meranze, and Rothman, 1938;Ross, Iber, and Harvey, 1956;Gibbons, 1957), but the level of alkaline phosphatase does not correlate with the extent of the infiltration.…”

Section: Tissue Of Originmentioning

confidence: 99%

Origins of serum alkaline phosphatase

Yong

1967

Journal of Clinical Pathology

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SYNOPSIS A very rapid method of agar gel electrophoresis on glass slides, together with a superior visualization technique employing simultaneous coupling of a hydrolysed naphthol substrate, have been developed for the identification of the tissues of origin of serum alkaline phosphatase. Combined with L-phenylalanine inhibition, specific for the intestinal enzyme, and heat inactivation, specific for the placental enzyme, the heterogeneity of serum alkaline phosphatase has been demonstrated. Normal adult serum contains predominantly liver-type alkaline phosphatase with a small but variable quantity of intestinal enzyme, and little or no bone enzyme.In childhood and in infancy there is in addition a bone isoenzyme present, the amount gradually falling to adult levels with age. In pregnancy, the rise in serum alkaline phosphatase is due to the placental enzyme.A study of nearly 2,000 sera has been undertaken and it is found that the bone enzyme is increased in osteoblastic bone diseases while in hepato-biliary disorders there is an increase in liver type enzyme. The main theories explaining the rise in serum alkaline phosphatase are examined.The origin of serum alkaline phosphatase has interested many workers ever since Kay (1929) and Roberts (1930) first demonstrated that increased serum activity was found in certain bone and hepatobiliary disorders. The problem of the origin of the enzyme is intricately bound up with that of the mechanisms by which the serum activity is increased or decreased in health and in disease. It has long been realized that serum alkaline phosphatase arises from tissues rich in the enzyme (Kay, 1932). Previous attempts at identification of the tissues of origin were handicapped not only by lack of direct methods, but also by the influence of the work of Robison and his associates linking alkaline phosphatase with calcification (

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“…The serum alkaline phosphatase activity is increased in bone diseases associated with increased osteoblastic activity and in certain disorders of the liver and biliary tract, particularly those characterized by biliary tract obstruction or by hepatic infiltration with neoplastic or granulomatous processes (1,2). Although there is much experimental evidence in support of the view that bone is the source of the serum alkaline phosphatase and that the bile serves as an important channel for its excretion (3,4), the hepatic retention theory fails to provide a completely satisfactory explanation for the occurrence, in certain hepatobiliary disorders, of increased serum phosphatase activity without hyperbilirubinemia, nor does it account for the normal serum phosphatase values found in many cases of severe parenchymatous liver disease.…”

mentioning

confidence: 99%

Zone Electrophoretic Studies of Serum Alkaline Phosphatase*†

Rosenberg¹

1959

J. Clin. Invest.

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The serum alkaline phosphatase in chronic infiltrative disease of the liver

Cited by 49 publications

References 21 publications

Tuberculosis as an Etiological Factor in Liver Abscess in Adults

Tuberculosis as an Etiological Factor in Liver Abscess in Adults

Origins of serum alkaline phosphatase

Zone Electrophoretic Studies of Serum Alkaline Phosphatase*†

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