The serotonin 2A −1438 G/A receptor polymorphism in a group of Swedish male criminals

Berggård, Cecilia; Damberg, Mattias; Longato-Stadler, Eva; Hallman, Jarmila; Oreland, Lars; Garpenstrand, Håkan

doi:10.1016/s0304-3940(03)00699-2

Cited by 31 publications

(17 citation statements)

References 19 publications

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“…However, Chee et al [17] reported that the -1438A allele of the 5-HTR2A gene promoter was statistically significantly associated with bipolar disorder in a Korean population, which is similar to our result. Furthermore, in Caucasian populations, the 5-HTR2A -1438A allele has been shown to be associated with eating disorders [20], impulsive traits in alcohol dependents [21], and criminal offenders [22]. However, in an Asian population, the 5-HTR2A -1438G allele was reported to be associated with alcoholism [23].…”

Section: Discussionmentioning

confidence: 99%

Association between Major Depressive Disorder and the –1438A/G Polymorphism of the Serotonin 2A Receptor Gene

Choi

Lee

et al. 2004

Neuropsychobiology

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This study investigated the possible effect of the –1438A/G single-nucleotide polymorphism in the promoter region of the serotonin 2A receptor (5-HTR2A) gene on major depressive disorder (MDD) in a Korean population. This polymorphism was analyzed in 189 patients with MDD and in 148 unrelated healthy controls using a case-control design, which revealed a significant difference in the genotype distributions (χ² = 10.78, d.f. = 2, p = 0.005). The frequency of the –1438G allele was also much higher in MDD patients than in normal controls (χ² = 7.20, p = 0.007; OR = 1.52, 95% CI 1.12–2.06). We also found significantly more carriers of the G allele (GG+AG genotypes) in MDD patients than in normal controls (χ² = 10.18, p = 0.001; OR = 2.46, 95% CI 1.40–4.32). Our results support the hypothesis that the –1438A/G polymorphism of the promoter region of the 5-HTR2A gene is associated with MDD patients in a Korean population.

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Section: Discussionmentioning

confidence: 99%

Association between Major Depressive Disorder and the –1438A/G Polymorphism of the Serotonin 2A Receptor Gene

Choi

Lee

et al. 2004

Neuropsychobiology

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“…Genetic influences of serotonin on impulsive aggression have been observed in a number of studies. Research has found associations between serotonergic dysfunction, specifically low levels of the serotonin genotype 5-HT2A-1438 GG, and criminal behavior (Berggard, Damberg, Longato-Stadler, Hallman, Oreland, & Garpenstrand, 2003). Additionally, in individuals with anger-related traits, an association between a tryptophan hydroxlase gene polymorphism and 5-HIAA levels in CSF has been found (Rujescu, Giegling, Bondy, Gietl, Zill, & Moller, 2002).…”

Section: Neurochemical Mechanisms Of Impulsive Aggressionmentioning

confidence: 99%

Role of serotonin and dopamine system interactions in the neurobiology of impulsive aggression and its comorbidity with other clinical disorders

Seo

Patrick

Kennealy

2008

Aggression and Violent Behavior

402

249

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Impulsive aggression is characterized by an inability to regulate affect as well as aggressive impulses, and is highly comorbid with other mental disorders including depression, suicidal behavior, and substance abuse. In an effort to elucidate the neurobiological underpinnings of impulsive aggression and to help account for its connections with these other disorders, this paper reviews relevant biochemical, brain imaging, and genetic studies. The review suggests that dysfunctional interactions between serotonin and dopamine systems in the prefrontal cortex may be an important mechanism underlying the link between impulsive aggression and its comorbid disorders. Specifically, serotonin hypofunction may represent a biochemical trait that predisposes individuals to impulsive aggression, with dopamine hyperfunction contributing in an additive fashion to the serotonergic deficit. The current paper proposes a modified diathesis-stress model of impulsive aggression in which the underlying biological diathesis may be deficient serotonergic function in the ventral prefrontal cortex. This underlying disposition can be manifested behaviorally as impulsive aggression towards oneself and others, and as depression under precipitating life stressors. Substance abuse associated with impulsive aggression is understood in the context of dopamine dysregulation resulting from serotonergic deficiency. Also discussed are future research directions in the neurobiology of impulsive aggression and its comorbid disorders.

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“…Elevated frequencies of the A allele were also reported to be associated with susceptibility to anorexia nervosa (Collier et al, 1997) and criminal behavior by Swedish males (Berggard et al, 2003). Although no associations between 5-HT2A receptor gene polymorphisms and anorexia nervosa (Ziegler et al, 1999) or bipolar affective disorder (Robertson, Jones, Middle, Moray, & Craddock, 2003) have been reported, behavioral studies in healthy adult humans support the idea of a significant association between them in the continuous performance task and the Go/No-Go task.…”

Section: -Ht 2a Gene Polymorphismmentioning

confidence: 98%

The Interplay of Genetic and Environmental Influences on Prefrontal Function and Self-Regulation of Impulsivity

Nomura

2011

PSYCHOLOGIA -An International Journal of Psychological Sciences

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Self-regulation of impulsivity via maturation of the executive resources benefits our well-being. The review of behavioral, neuroimaging, and pharmacological studies appears to provide evidence of a relationship between the self-regulation of impulsivity, activity of the prefrontal cortex, and serotonergic neurotransmission. Although a wide range of genetic, developmental, and social factors exists, much of this information, their interactive mechanisms in particular, remains to be clarified. Thus, in the present article, I first review the brain functions that underlie selfregulative processes and then provide an update on recent findings regarding serotonergic neurotransmission. Next, by integrating findings from behavioral genetics that examine the association between gene polymorphism and impulsivity, I discuss the bright sides of the risk allele of gene polymorphism. Finally, I argue the future direction of genetic and environmental bidirectional studies.

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The serotonin 2A −1438 G/A receptor polymorphism in a group of Swedish male criminals

Cited by 31 publications

References 19 publications

Association between Major Depressive Disorder and the –1438A/G Polymorphism of the Serotonin 2A Receptor Gene

Association between Major Depressive Disorder and the –1438A/G Polymorphism of the Serotonin 2A Receptor Gene

Role of serotonin and dopamine system interactions in the neurobiology of impulsive aggression and its comorbidity with other clinical disorders

The Interplay of Genetic and Environmental Influences on Prefrontal Function and Self-Regulation of Impulsivity

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