Association between Major Depressive Disorder and the –1438A/G Polymorphism of the Serotonin 2A Receptor Gene

Choi, Moon-Gi; Lee, Heon Jeong; Lee, Hye Jin; Ham, Byung‐Joo; Hyun, Jae Chun; Ryu, Seung Ho; Lee, Min Soo

doi:10.1159/000075337

Cited by 64 publications

(45 citation statements)

References 19 publications

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“…Regarding association studies in various ethnic samples, the rs6311 A allele has been found to be associated with an increased risk for MDD in Swedish (Jansson et al, 2003) and Danish (Christiansen et al, 2007) populations, whereas the association between the rs6311 G allele and an increased risk for MDD has been reported in a Korean study (Choi et al, 2004). Nevertheless, negative associations between this SNP and MDD have been revealed in other populations including the Japanese (Ohara et al, 1998;Kishi et al, 2009), Israeli-Jewish (Frisch et al, 1999), Caucasians from France (Bonnier et al, 2002), and Finnish (Illi et al, 2009).…”

Section: Introductionmentioning

confidence: 94%

No relationship found between -1438A/G polymorphism of the serotonin 2A receptor gene (rs6311) and major depression susceptibility in a northeastern Thai population

Tencomnao¹,

Thongrakard²,

Phuchana³

et al. 2010

Genet. Mol. Res.

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ABSTRACT. Several lines of evidence suggest a molecular role of -1438A/G single nucleotide polymorphism in the 5-HTR2A gene promoter (rs6311) in regulating the expression of this gene, making rs6311 polymorphism a promising candidate for an association study. We looked for a possible association between rs6311 polymorphism and major depressive disorder (MDD) in a northeastern Thai population. We included 180 patients with MDD and 183 unrelated healthy controls in our study. Genotyping was performed using PCR-RFLP. We found no significant differences between the two groups with

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Section: Introductionmentioning

confidence: 94%

No relationship found between -1438A/G polymorphism of the serotonin 2A receptor gene (rs6311) and major depression susceptibility in a northeastern Thai population

Tencomnao¹,

Thongrakard²,

Phuchana³

et al. 2010

Genet. Mol. Res.

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“…5-HT2A receptor polymorphisms are generally not associated with major depression (Zhang et al 1997;Frisch et al 1999;Tsai et al 1999;Minov et al 2001;Oswald et al 2003;Choi et al 2004;Khait et al 2005;Levinson 2005). …”

Section: -Ht Receptorsmentioning

confidence: 99%

Consensus paper of the WFSBP Task Force on Biological Markers: Biological Markers in Depression

Mößner

Mikova

Koutsilieri

et al. 2007

The World Journal of Biological Psychiatry

226

126

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Biological markers for depression are of great interest to aid in elucidating the causes of major depression. We assess currently available biological markers to query their validity for aiding in the diagnosis of major depression. We specifically focus on neurotrophic factors, serotonergic markers, biochemical markers, immunological markers, neuroimaging, neurophysiological findings, and neuropsychological markers. We delineate the most robust biological markers of major depression. These include decreased platelet imipramine binding, decreased 5-HT1A receptor expression, increase of soluble interleukin-2 receptor and interleukin-6 in serum, decreased brain-derived neurotrophic factor in serum, hypocholesterolemia, low blood folate levels, and impaired suppression of the dexamethasone suppression test. To date, however, none of these markers are sufficiently specific to contribute to the diagnosis of major depression. Thus, with regard to new diagnostic manuals such as DSM-V and ICD-11 which are currently assessing whether biological markers may be included in diagnostic criteria, no biological markers for major depression are currently available for inclusion in the diagnostic criteria.

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“…Recent evidence supports this hypothesis. The serotonin 2A gene was associated with MDD in the Korean population, 22 but not in Japanese population. 23 rs6295 (C-1019G) in the promoter region regulates HTR1A transcription.…”

Section: Discussionmentioning

confidence: 83%

Serotonin 1A receptor gene and major depressive disorder: an association study and meta-analysis

et al. 2009

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Several genetic studies have shown an association between the 5-HT1A receptor gene (HTR1A) and major depressive disorder (MDD); however, results have been rather inconsistent. Moreover, to our knowledge, no association study on HTR1A and MDD in the Japanese population has been reported. Therefore, to evaluate the association between HTR1A and MDD, we conducted a case-control study of Japanese population samples with two single-nucleotide polymorphisms (SNPs), including rs6295 (C-1019G) in HTR1A. In addition, we conducted a meta-analysis of rs6295, which has been examined in other papers. Using one functional SNP (rs6295) and one tagging SNP (rs878567) selected with the HapMap database, we conducted a genetic association analysis of case-control samples (331 patients with MDD and 804 controls) in the Japanese population. Seven population-based association studies, including this study, met our criteria for the meta-analysis of rs6295. We found an association between rs878567 and Japanese MDD patients in the allele-wise analysis, but the significance of this association did not remain after Bonferroni's correction. We also did not detect any association between HTR1A and MDD in the allele/ genotype-wise or haplotype-wise analysis. On the other hand, we detected an association between rs6295 and MDD in the metaanalysis (P(Z)¼0.0327). In an explorative analysis, rs6295 was associated with Asian MDD patients after correction for multiple testing (P(Z)¼0.0176), but not with Caucasian MDD patients (P(Z)¼0.138). Our results suggest that HTR1A may not have a role in the pathophysiology of Japanese MDD patients. On the other hand, according to the meta-analysis, HTR1A was associated with MDD patients, especially in the Asian population. Keywords: case-control study; functional SNP; major depressive disorder (MDD); meta-analysis; serotonin 1A receptor gene (HTR1A); tagging SNP INTRODUCTION Altered serotonergic neural transmission is hypothesized to be a susceptibility factor for major depressive disorder (MDD). The evidence for such an association is discussed in more detail in reviews. 1,2 Several genetic studies have shown an association between the serotonin 1A (5-HT1A) receptor gene (HTR1A) and MDD; however, results have been rather inconsistent. A recent meta-analysis showed no association between HTR1A and MDD. 3 However, two very recent studies reported that rs6295 (C-1019G) in the promoter region of HTR1A, which regulates HTR1A transcription, 4,5 was associated with MDD in the Chinese population. 6,7 Moreover, to our knowledge, no association study of HTR1A and MDD in the Japanese population has been reported. Therefore, we examined the association between HTR1A and MDD in the Japanese, using the recently recommended strategy of 'genebased' association analysis. 8 Moreover, we conducted an updated

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Association between Major Depressive Disorder and the –1438A/G Polymorphism of the Serotonin 2A Receptor Gene

Cited by 64 publications

References 19 publications

No relationship found between -1438A/G polymorphism of the serotonin 2A receptor gene (rs6311) and major depression susceptibility in a northeastern Thai population

No relationship found between -1438A/G polymorphism of the serotonin 2A receptor gene (rs6311) and major depression susceptibility in a northeastern Thai population

Consensus paper of the WFSBP Task Force on Biological Markers: Biological Markers in Depression

Serotonin 1A receptor gene and major depressive disorder: an association study and meta-analysis

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