The seroepidemiology of infection due to Epstein‐Barr virus in southern India

Venkitaraman, Ashok R.; Lenoir, Gilbert; John, Thomas

doi:10.1002/jmv.1890150103

Cited by 33 publications

(18 citation statements)

References 16 publications

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“…Virus-specific serology strongly suggests that the vast majority o f children experienced a primary infection before 10 years. Our data are in agreement with other epidemiological reports conducted on low or middle socioeconomic groups from several countries, in which a very high rate o f EBV immunity was already present in early childhood (1,2,3,16,17,18). The IgM responses were less frequent (0.90/0) in accordance with findings obtained by other investigators.…”

Section: Resultssupporting

confidence: 83%

Studies on the epidemiology of child infections in the Bari area (South Italy) VII. Epidemiology of Epstein-Barr virus infections

Leogrande

Jirillo

1993

Eur J Epidemiol

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Serological patterns against Epstein-Barr virus (EBV) specific antigens were determined in 3732 healthy babies and children aged 0-10 years living in the Bari area (South Italy). IgG antibodies against EBV capsid antigen (VCA) were found in 2713 subjects (72.7%). Seropositivity rates, high in the first semester of life (83.8%), declined between 6 and 12 months (65.6%) and even further between 1 and 2 years (43.8%). After 2 years the frequency of positive children rose progressively reaching steady levels between 5 and 7 years (80.2%) and between 8 and 10 years (81.9%). IgA antibodies against VCA, IgG anti-early viral antigen (EA) and IgG against virus-associated nuclear antigens (EBNA) were found in 17.9%, 15.9% and 25.7% of the subjects tested, respectively. IgM anti-VCA were found only in 35 (0.9%) children, but 818 (21.9%) exhibited antibody patterns suggestive of a recent infection: IgG anti-VCA > or = 1:160 alone or in association with IgA anti-VCA or IgG anti-EA or both. These results suggest that in this area the primary infection by EBV occur early in life, with immunity to EBV acquired primarily after 4 years.

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Section: Resultssupporting

confidence: 83%

Studies on the epidemiology of child infections in the Bari area (South Italy) VII. Epidemiology of Epstein-Barr virus infections

Leogrande

Jirillo

1993

Eur J Epidemiol

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“…Interestingly, our results show that the incidence of EBV early in childhood is significantly higher as compared to HHV-8. A very similar seroprevalence rate has been reported for EBV in some Asian countries such as India, where Venkitaraman et al have reported that IgG antibodies to VCA rose rapidly to 90% by 5 years of age [11]. The prevalence of VCA-specific IgM and the geometric mean titer of VCA-specific IgG antibodies were highest between the ages of 6 months and 2 years, the median age of primary infection being 1.4 years.…”

Section: Discussionsupporting

confidence: 69%

Primary gamma-herpesviral infection in Zambian children

et al. 2010

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BackgroundHHV-8 is closely related to Epstein-Barr virus (EBV), but the clinical presentations of these two infections in early childhood are not well understood. Also, it is not known whether infection by one virus correlates with another. Here, we compare the natural history of infection by these two viruses along with the clinical manifestations and risk factors that are associated with early childhood infection in Zambia, which is an endemic area for HHV-8.MethodsThis study was conducted in a cohort of 12 month old Zambian children (N = 677). Data on socio-economic status and a wide range of clinical manifestations were collected. Logistic regression was used to test for significant associations between the collected variables and HHV-8 or EBV serostatus at 12 months of age.ResultsWe observed a significantly higher seroprevalence for EBV (58.9%) as compared to HHV-8 (13.4%). HIV-1 infected children had at a significantly higher risk of being infected with HHV-8 (Odds ratio [OR] 3.69, 95% confidence interval [CI] 1.64 - 8.32). HIV-1 infection of the mothers was a significant risk factor for increased acquisition of EBV but not HHV-8 by children (OR 1.86, 05% CI 1.20 - 2.87). Self reported rash was marginally associated with primary infection for HHV-8 and EBV.ConclusionsThese results suggest that there is no correlation between EBV and HHV-8 infections. Infection by one does not increase the susceptibility for the second virus. Primary HHV-8 and EBV infection in early childhood may clinically present as rash but remains largely asymptomatic and may remain undetected in this population. HIV infection in the mother or child are important risk factors that contribute to EBV or HHV-8 infection.

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“…In southern India, more than 90% of children had IgG antibodies to EBV-VCA by the age of 5 years [Venkitaraman et al, 1985]. The age-specific seroprevalence of anti-EBV antibodies in the population of India is similar to those from areas where EBVassociated Burkitt's lymphoma is endemic.…”

Section: Discussionmentioning

confidence: 85%

Epstein‐Barr virus‐associated gastric carcinoma in southern India: A comparison with a large‐scale Japanese series

Jayasree

Koriyama

Akiba

et al. 2002

Journal of Medical Virology

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Epidemiological and clinicopathological features of Epstein-Barr virus (EBV) associated gastric carcinoma was compared in India and Japan, two countries differing markedly in gastric cancer incidence. Using in situ hybridization assay, the presence of EBV-encoded small RNA (EBER) was examined in 215, and 2,011 gastric cancer cases in Kerala, India, and Japan, respectively. Ten cases (5%), all males, in the Indian series were EBER-positive. This frequency was similar to that in the Japanese series (6.2%). As was the case with Japanese series, the EBV-associated gastric carcinoma in the Indian series was observed most frequently in the middle part of the stomach (1 in antrum, 4 in middle part, 2 in cardia, and 3 unknown), and, histologically, the diffuse type Lauren's classification (8 cases) was more common than the intestinal type (2 cases). Virus subtyping by PCR-RFLP revealed that all of the 10 EBV strains isolated from the EBER-positive Indian cases were subtype A, and wild-type F for Bam HI F region. In Bam HI I region, 8 cases were type C and the remaining 2 cases were type D. In either series, there was no significant difference in the frequency of tumors with p53 overexpression between EBER-positive and -negative cases. However, the proportion of cells with p53 overexpression in EBER-negative tumors was significantly higher than that in EBER-positive tumors regardless of histological type in both series. In conclusion, the frequency and major clinicopathological features of EBV-associated gastric carcinoma in south India were similar to those observed in Japanese series although gastric cancer incidence in these two countries differs markedly.

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The seroepidemiology of infection due to Epstein‐Barr virus in southern India

Cited by 33 publications

References 16 publications

Studies on the epidemiology of child infections in the Bari area (South Italy) VII. Epidemiology of Epstein-Barr virus infections

Studies on the epidemiology of child infections in the Bari area (South Italy) VII. Epidemiology of Epstein-Barr virus infections

Primary gamma-herpesviral infection in Zambian children

Epstein‐Barr virus‐associated gastric carcinoma in southern India: A comparison with a large‐scale Japanese series

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