The separation of arsenic-77 in a carrier-free state from the parent nuclide germanium-77 by a thin-layer chromatographic method

Separation and purification of no-carrier-added arsenic from bulk amounts of germanium for use in radiopharmaceutical labelling

“…Maki and Murakami [41] developed a separation technique for 77 Ge, 77 As(III) and 77 As(V) by TLC with and without the addition of arsenic carrier. Caletka and Kotas [42] developed a separation technique based on the absorption of germanium in 8 M HCl or other mineral acids on silica gel columns.…”

“…This was monitored by a radio TLC method. While mixtures of HCl/acetone [13,41] lead to destruction of the TLC plate, a mixture of sodium tartrate and methanol was chosen. The R f values of 0.9 for * As(V), 0.6 for * As(III) and 0 for * As-labelled mab (see Fig.…”

Separation methods for high specific activity radioarsenic

“…[8][9][10][11] Either natural or enriched targets of GeO 2 or Ge metal have been irradiated with thermal neutrons according to the 76 Ge(n,ܵ) 77 Ge reaction; 77 Ge then decays by beta emission with an 11.3 hour half-life to 77 As. The 77 As has been separated from the Ge target material using sorbents (silica gel 8 or hydrous zirconium oxide 11 ) or complex extraction methods. 9,10 The separation utilized in these studies was based on the extraction method of Shehata 12 to generate 77 As(III) or 77 As(V) for potential radiolabeling studies.…”

Polymer Embedded Nanocrystalline Titania: A New Generation Sorbent for the Separation of 77As from Ge for Biomedical Applications

“…77 As can be produced at a cyclotron/ accelerator by deuteron-induced reaction on enriched 76 Ge targets. In addition, an alternative path using nuclear reactors could also be followed wherein the natural GeO 2 or Ge target undergoes (n, c) reaction to produce 77 Ge, which subsequently decays by b --emission (t = 11.3 h) to yield 77 As [12][13][14]. This requires efficient radiochemical separation of 77 As from large amounts of Ge target material.…”

“…This requires efficient radiochemical separation of 77 As from large amounts of Ge target material. In the past few years, there have been considerable efforts towards development of effective separation techniques involving distillation, co-precipitation, solvent extraction, thin layer chromatography, etc., for the isolation of 77 As from cyclotron or reactor irradiated germanium or germanium oxide targets [13][14][15][16][17][18][19][20][21][22][23].…”