Polymer Embedded Nanocrystalline Titania: A New Generation Sorbent for the Separation of 77As from Ge for Biomedical Applications

Chakravarty, Rubel; Ram, Ramu; Jagdeesan, K. C.; Venkatesh, Meera; Dash, Ashutosh

doi:10.1007/s10337-011-2113-4

Cited by 8 publications

(10 citation statements)

References 23 publications

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“…Disadvantageous is the use of high concentrations of strong acids (HNO 3 , HCl, and HF), which hinders the subsequent radiolabelling . Attempts were made to improve the ion exchange technique by introduction of other sorbents, such as hydrous zirconium oxide or polymer‐embedded nanocrystalline titania …”

Section: As and 74asmentioning

confidence: 99%

“…An alternative radiochemical separation is based on selective and quantitative extraction of As(III) in an organic phase followed by back extraction done with a H 2 O 2 solution . Further methods were developed using thin‐layer chromatography, column chromatography, distillation, or solid‐phase extraction . Recently, a high‐performance liquid chromatography separation by an anion exchange column was used to isolate nca radioarsenic …”

Section: As and 74asmentioning

confidence: 99%

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Labelling with positron emitters of pnicogens and chalcogens

Neumaier

2017

Labelled Comp Radiopharmac

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The increasing importance of the positron emission tomography (PET) in clinical diagnosis led to the development of a multitude of radiotracers labelled with positron‐emitting radionuclides of groups 15 (pnicogens) and 16 (chalcogens) of the periodic table of elements. The positron emitters of the endogenous occurring elements nitrogen, phosphorus, oxygen, and sulphur are characterized by very short half‐lives compared with the most commonly used PET radionuclides carbon‐11 or fluorine‐18. Therefore, the potential of their synthesis and possible applications in PET is challenging and limited. On the other hand, the nonstandard positron emitters arsenic‐72, arsenic‐74, and selenium‐73 have half‐lives in the range of hours to days and, thus, are of interest for PET studies of processes with long biological half‐lives, but novel methods have to be developed for their application, especially in the no‐carrier‐added state. This review summarizes recent research concerning the positron emitters of pnicogens and chalcogens for radiolabelling applications.

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Section: As and 74asmentioning

confidence: 99%

Section: As and 74asmentioning

confidence: 99%

Labelling with positron emitters of pnicogens and chalcogens

Neumaier

2017

Labelled Comp Radiopharmac

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“…Many methods to isolate As from Ge have been reported including solvent extraction [5, 6], distillation [7, 8], ion exchange [8-10], solid phase extraction [11-13], and thin layer chromatography [14]. The solvent extraction methods reported often involve several labor intensive steps, including back extractions, and are not readily adapted for high activity separations requiring remote handling.…”

Section: Introductionmentioning

confidence: 99%

“…Many of the current literature methods involve the use of strong acids (e.g., >8 M HNO 3 , HF, HCl) in the separation process, which are undesirable for radionuclides that will be used for synthesizing radiopharmaceuticals [8-12]. Chakravarty [13] reported a two-column separation for high purity radioarsenic from a GeO 2 target using nanocrystalline titania. This method requires the synthesis and strict quality control of the nanocrystalline titania, which is not commercially available.…”

Section: Introductionmentioning

confidence: 99%

Chromatographic separation of germanium and arsenic for the production of high purity 77As

Gott

DeGraffenreid

Feng

et al. 2016

Journal of Chromatography A

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A simple column chromatographic method was developed to isolate 77As (94 ± 6% (EtOH/HCl); 74 ± 11 (MeOH)) from germanium for potential use in radioimmunotherapy. The separation of arsenic from germanium was based on their relative affinities for different chromatographic materials in aqueous and organic environments. Using an organic or mixed mobile phase, germanium was selectively retained on a silica gel column as germanate, while arsenic was eluted from the column as arsenate. Subsequently, enriched 76Ge (98 ± 2) was recovered for reuse by elution with aqueous solution (neutral to basic). Greater than 98% radiolabeling yield of a 77As-trithiol was observed from methanol separated [77As]arsenate [17].

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“…They are polymer embedded nanocrystalline titania (TiP), mixed phase nano-zirconia (nano-ZrO 2 ) tetragonal nano-zirconia (t-ZrO 2 ), nanocrystalline alumina (γ-Al 2 O 3 ), and nano-ceria-polyacrylonitrile composite (CeO 2 -PAN) [2,9,10].…”

mentioning

confidence: 99%

Preparation and Characterization of Zirconia Nanomaterial as a Molybdenum-99 Adsorbent

et al. 2017

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The present study deals with the synthesis and characterization of ZrO 2 nanomaterial which can be used as an adsorbent for Molybdenum-99 ( 99 Mo).The adsorbent can potentially be utilized as the material for 99 Mo/ 99m Tc generator column. Using the sol-gel method, monoclinic nanocrystalline zirconia was synthesized from zirconium oxychloride in isopropyl alcohol reacted with ammonium hydroxide solution in isopropyl alcohol resulting in a white gel. The gel was subsequently refluxed for 12 hours at ~95 °C and pH at ~4 and then dried at 100 °C. The drying gel was then calcined at 600 °C for two hours. Meanwhile the orthorhombic nanocrystalline zirconia was obtained by reacting zirconium oxychloride solution with 2.5 M ammonium hydroxide solution which resulted in a white gel. The gel was then refluxed for 24 hours at ~95 °C and pH at ~11 and then dried at 100 °C. The drying gel was then calcined at 600 °C for two hours. These materials were characterized using FT-IR spectroscopy, X-ray diffraction (XRD), and Transmission Electron Microscope (TEM). The Scherrer method is used for determination of crystallite size. The FT-IR spectra for both materials show absorption peak at 450-500 cm -1 which are attributed to Zr-O bond. The XRD pattern of monoclinic nanocrystalline form shows crystalline peaks at 2θ regions of 28.37 °, 31.65 °, 34 °, 36 ° and 50.3 ° with average crystallite size of 2.68 nm. Meanwhile, the XRD pattern of orthorhombic nanocrystalline form shows crystalline peaks at 2θ regions of 30 °, 35 °, 50 ° and 60 ° with average crystallite size of 0.98 nm. The TEM micrograph indicates that the zirconia nanomaterials prepared were quite uniform in size and shape.

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Polymer Embedded Nanocrystalline Titania: A New Generation Sorbent for the Separation of 77As from Ge for Biomedical Applications

Cited by 8 publications

References 23 publications

Labelling with positron emitters of pnicogens and chalcogens

Labelling with positron emitters of pnicogens and chalcogens

Chromatographic separation of germanium and arsenic for the production of high purity 77As

Preparation and Characterization of Zirconia Nanomaterial as a Molybdenum-99 Adsorbent

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