The separation from <i>Clostridium welchii</i> of variants which differ in toxicity and antigenic structure

McGaughey, C.A.

doi:10.1002/path.1700360208

Cited by 11 publications

(3 citation statements)

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“…Moreover, since similar polysaccharides were extractable from infected muscle, they suggested that this technique might afford a rapid method of diagnosis. I have no experience with this test, but in view of the work on the great antigenic variability of C. perfringens (79,434,437,460,687,703,704,799,886) am inclined to doubt its wide applicability (see, however, Svec and McCoy (982)).…”

Section: Serological Methodsmentioning

confidence: 99%

The Histotoxic Clostridial Infections of Man 12

Maclennan

1962

Bacteriological Reviews

259

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Section: Serological Methodsmentioning

confidence: 99%

The Histotoxic Clostridial Infections of Man 12

Maclennan

1962

Bacteriological Reviews

259

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“…The work on this subject which has been reviewed by Weinberg (1936) and Henriksen (1937) shows that little attention has been given to the serology of the bacterial antigens occurring in the numerous stable variants that have been described. McGaughey (1933) and Henriksen (1937) in each plating as typical Cl. welchii complied with the text-book description as "low convex, amorphous, with smooth surface and entire edge".…”

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confidence: 99%

“…The somatic antigens were obtained from two strains of type B (one typical and the other no longer produced E toxin), one of type C and one of type D. Their appearance on agar plates resembled closely McGaughey's (1933) variant I of a Cl. welchii type A strain.…”

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confidence: 99%

The somatic antigens of theCl. welchiigroup of organisms

Henderson

1940

Epidemiol. Infect.

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The complex group of organisms with cultural and biochemical properties closely similar to the classicalCl. welchiiare at present differentiated into four types according to the quality and number of the toxins they elaboratein vitro.The present study is concerned with the specific affinities of the bacterial antigens of representative strains from these four types. The experiments confirm earlier reports concerning a wide diversity in the specificity of the somatic antigens of the classical type A strains. The bacterial antigens of the types B, C and D, however, have been shown to possess interesting similarities and affinities:(1) The O antigen of type A (classicalCl. welchii) strains is strictly strain specific.(2) The type B (L.D. bacillus) strains isolated in Great Britain share an identical O antigen but a strain from South Africa had a strictly specific O component.(3) The O antigen of the type C (B. paludis) strains isolated in Great Britain is identical.(4) The type D (B. ovitoxicus) strains exhibit wide diversity in the specificity of their O component. Thirteen strains were placed in not less than seven groups.(5) Cross O reactions between various types is negligible or entirely absent.(6) In addition to the heat-stable O antigen certain strains possess a heat-labile somatic component. This antigen occurs only among those types (B and D) that produce ɛ toxin but it is probably not present in all strains.(7) Colony variants reminiscent of the typical rough forms of Gram-negative organisms are frequently encountered among strains of each type. Certain of these forms appear as stable variants and they are characterized serologically by the loss of O antigen specific for the strain.(8) The rough forms still produce toxins characteristic of the type to which the parent culture belongs.

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Clostridium welchii: Notes on the relationship between the types of cultures and the production of toxin

Dalling

Ross

1938

Journal of Comparative Pathology and Therapeutics

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The separation from Clostridium welchii of variants which differ in toxicity and antigenic structure

Cited by 11 publications

References 2 publications

The Histotoxic Clostridial Infections of Man 12

The Histotoxic Clostridial Infections of Man 12

The somatic antigens of theCl. welchiigroup of organisms

Clostridium welchii: Notes on the relationship between the types of cultures and the production of toxin

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