The Histotoxic Clostridial Infections of Man 12

Gas gangrene of the extremity: The presenting clinical picture in perforating carcinoma of the caecum

“…Clostridium perfringens, C. septicum, C. novyi, C . hisiolyticum, C. fallax and C. bijermentans under the appropriate conditions will cause tissue necrosis and myositis (MacLennan, 1962). C. tertbm, on the other hand, does not cause gas gangrene (MacLennan, 1962), but this organism in conjunction with anaerobic streptococci and E. coli can lead to necrosis, as demonstrated in one of our patients.…”

“…Clostridia are normal inhabitants of the digestive tract and can be easily isolated and cultured from the faeces (MacLennan, 1962). Tissue necrosis is a necessary antecedent to clostridial myositis.…”

Enzyme-linked immunosorbent assay for rapid detection of toxins from Clostridium perfringens

“…The various types of C. perfringens are known to be associated with the following diseases: strains of type A cause gas gangrene in man [2,3], strains of type B are the cause of lamb dysentery [4], strains of type C are the cause of necrotic enteritis in man and animals [5,6], strains of type D are associated with enterotoxaemia in animals [4,7] and type E strains are the cause of clindamycinassociated colitis in rabbits [8]. The detection of these toxins seems to be important, especially with respect to the clinical diagnosis of bacteria!…”

Effect of Clostridium perfringens Alpha Toxin on Contraction of Isolated Guinea‐Pig Diaphragm

“…The data showed that the toxin impairs contraction of isolated guinea-pig diaphragm. Clostridium perfringens alpha toxin is thought to be a main causative factor in gas gangrene by the microorganism (1,11 tissue with the toxin. The inhibitory effect of the toxin was not reversed by washing the tissue (Fig.…”