The Sentinel Lymph Node Biopsy Using Indocyanine Green Fluorescence Plus Radioisotope Method Compared With the Radioisotope-Only Method for Breast Cancer Patients After Neoadjuvant Chemotherapy: A Prospective, Randomized, Open-Label, Single-Center Phase 2 Trial

Jung, So‐Youn; Han, Jai Hong; Park, Soo‐Jin; Lee, Eun‐Gyeong; Kwak, Joohwa; Kim, Sun Hye; Lee, Moo Hyun; Lee, Eun Sook; Kang, Hyejin; Lee, Keun Seok; Park, In Hae; Sim, Sung Hoon; Jeong, Hae Jeong; Kwon, Youngmee; Lee, Dong‐Eun; Kim, Seok-Ki; Lee, Seeyoun

doi:10.1245/s10434-019-07400-0

Cited by 40 publications

(41 citation statements)

References 25 publications

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“…The use of SLN in the concept of primary chemotherapy is not well admitted. These results are in accordance with the series of Jung et al (3). who have observed a SLN identification rate was 94.7% using ICG‐F and 93% using RI ( P = .79).…”

supporting

confidence: 89%

Reply–To Letter to the Editor; Prospective evaluation of the limitations of near‐infrared imaging in detecting axillary sentinel lymph nodes in primary breast cancer

et al. 2019

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supporting

confidence: 89%

Reply–To Letter to the Editor; Prospective evaluation of the limitations of near‐infrared imaging in detecting axillary sentinel lymph nodes in primary breast cancer

et al. 2019

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“…Oncologic studies using ICG-F to harvest sentinel lymph nodes have been reported 11 , 14 , 15 . The feasibility of sentinel lymph node biopsy using ICG-F for patients with early and advanced breast cancer after neoadjuvant therapy has been demonstrated 11 , 16 .…”

Section: Discussionmentioning

confidence: 99%

Surgical outcomes of localization using indocyanine green fluorescence in breast conserving surgery: a prospective study

Lee

Kim

Han

et al. 2021

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We investigated localization and safe resection margins for breast cancer patients undergoing breast conserving surgery (BCS) using ultrasound-guided indocyanine green fluorescence (ICG-F) marking. From April 2016 to March 2019, we prospectively enrolled 114 patients who underwent BCS using US-guided ICG-F marking and we compared these results with 300 patients who underwent BCS using US-guided skin marking from January 2012 to December 2016. Clinical features, identification rates, status of resection margins, and re-operation rates were analyzed. The ICG-F identification rate was 100% (114/114). The mean approach time for resection of the lesion ICG-F using group was about 13 min. The positive rate of frozen resection margins was 10.5% using ICG-F and 25.0% using sono-guided skin marking (p < 0.01). The rate of additional intraoperative resection was significantly lower in the ICG-F marking group compared to that in the sono-guided skin marking group (8.8% vs. 23.3%, p < 0.01). The rate of final positive resection margins was 3.5% in the ICG-F using group and 14.7% in the sono-guided skin marking group (p < 0.01). The rate of re-operation was 4.4% in the ICG-F using group and 4% in the sono-guided group (p = 0.79). At follow-up after the operation using ICG-F, no complications occurred. Using ICG-F during BCS could be a safe, sophisticated method for localization.

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“…If further substantiated that an EphB4 based near infrared fluorescence (NIRF) tracer could be used to detect positivity in sentinel lymph nodes, next to, or instead of the non-targeted near-infrared fluorescent agent indocyanine green (ICG). Sentinel lymph node mapping (SLM) with ICG has been shown to have comparable detection rates with standard-of-care radioactive tracers and blue dye [ 31 , 32 , 33 ]. Staining of metastatic cells in lymph nodes would substantially enhance the possibilities of fluorescent imaging and circumvent the limitations of ICG, such as poor aqueous stability, concentration-dependent aggregation, short half-life in the circulation, and lack of target specificity.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of EphB4 as Target for Image-Guided Surgery of Breast Cancer

et al. 2020

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Background: Targeted image-guided surgery is based on the detection of tumor cells after administration of a radio-active or fluorescent tracer. Hence, enhanced binding of a tracer to tumor tissue compared to healthy tissue is crucial. Various tumor antigens have been evaluated as possible targets for image-guided surgery of breast cancer, with mixed results. Methods: In this study we have evaluated tyrosine kinase receptor EphB4, a member from the Eph tyrosine kinase receptor family, as a possible target for image-guided surgery of breast cancers. Two independent tissue micro arrays, consisting of matched sets of tumor and normal breast tissue, were stained for EphB4 by immunohistochemistry. The intensity of staining and the percentage of stained cells were scored by two independent investigators. Results: Immunohistochemical staining for EphB4 shows that breast cancer cells display enhanced membranous expression compared to adjacent normal breast tissue. The enhanced tumor staining is not associated with clinical variables like age of the patient or stage or subtype of the tumor, including Her2-status. Conclusion: These data suggest that EphB4 is a promising candidate for targeted image-guided surgery of breast cancer, especially for Her2 negative cases.

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The Sentinel Lymph Node Biopsy Using Indocyanine Green Fluorescence Plus Radioisotope Method Compared With the Radioisotope-Only Method for Breast Cancer Patients After Neoadjuvant Chemotherapy: A Prospective, Randomized, Open-Label, Single-Center Phase 2 Trial

Cited by 40 publications

References 25 publications

Reply–To Letter to the Editor; Prospective evaluation of the limitations of near‐infrared imaging in detecting axillary sentinel lymph nodes in primary breast cancer

Reply–To Letter to the Editor; Prospective evaluation of the limitations of near‐infrared imaging in detecting axillary sentinel lymph nodes in primary breast cancer

Surgical outcomes of localization using indocyanine green fluorescence in breast conserving surgery: a prospective study

Evaluation of EphB4 as Target for Image-Guided Surgery of Breast Cancer

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