The self-setting properties and in vitro bioactivity of tricalcium silicate

Zhao, Weihong; Wang, Junying; Zhai, Wentao; Wang, Zheng; Chang, Jiang

doi:10.1016/j.biomaterials.2005.04.025

Cited by 265 publications

(284 citation statements)

References 20 publications

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“…Formation of hydroxyapatite was only observed on the WPC surface. The surface of WPC after reaction with SBF is seen to support a particle deposit of similar morphology to the apatite layer reported to www.scienceasia.org form on bioactive material [27][28][29] . The higher magnification SEM micrograph shows that small particles of an apatite formed as agglomerates (Fig.…”

Section: Bioactivity In Vitromentioning

confidence: 62%

Untitled

Torkittikul¹,

Chaipanich²

2009

ScienceAsia

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Biomaterials containing calcium silicate have been widely used in dental and bone repaired applications. This study investigated mechanical and in vitro biological properties of ordinary and white Portland cement both of which are composed mainly of calcium silicates. The time of setting was determined using a Vicat needle. Compressive strength was measured at the age of 1, 3, and 7 days. The 1 day set Portland cement pastes were soaked in a simulated body fluid to investigate the ability of the material to form a bond with living bone tissue. X-ray diffraction traces of samples following immersion in simulated body fluid demonstrated that both cement pastes form a hydroxyapatite layer within 7 days but white Portland cement shows a noticeably higher amount of apatite crystal than that of ordinary Portland cement. Scanning electron micrographs reveal a clear presence of hydroxyapatite on the surface of white, but not in ordinary Portland cement. In addition, white Portland cement can achieve a compressive strength of 30 MPa within 24 h after curing in distilled water at human temperature.

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Section: Bioactivity In Vitromentioning

confidence: 62%

Untitled

Torkittikul¹,

Chaipanich²

2009

ScienceAsia

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“…It should be noted that the tricalcium silicate paste as the matrix of the scaffold is inherently microporous [21]. Therefore, P total should be the summation of the inherent microporosity P micro of the reacted tricalcium silicate paste and the macroposity P macro created by the foaming agent.…”

Section: Porosity Determinationmentioning

confidence: 99%

“…From the biological and clinical point of view, tricalcium silicate possesses a number of important characteristics that are also noted for other silicate-containing bioactive materials. Being biocompatible, tricalcium silicate cement can induce bone-like apatite formation in simulated body fluid (SBF) and have the potential to stimulate cell proliferation [20,21]. Moreover, the hydration product of tricalcium silicate cement is degradable in SBF [21].…”

Section: Introductionmentioning

confidence: 99%

“…Being biocompatible, tricalcium silicate cement can induce bone-like apatite formation in simulated body fluid (SBF) and have the potential to stimulate cell proliferation [20,21]. Moreover, the hydration product of tricalcium silicate cement is degradable in SBF [21]. All those important features suggest that tricalcium silicate is a good candidate material.…”

Section: Introductionmentioning

confidence: 99%

“…In the present research, a low-temperature fabrication method for macroporous bioactive C 3 S scaffolds was developed on the basis of the prior experience gained in working with tricalcium silicate cement [21] and the lowtemperature fabrication method using hydrogen peroxide (H 2 O 2 ) as a foaming agent that was developed by Ginebra et al [22]. It was expected that porous scaffolds with sufficient mechanical strength could be fabricated through the foaming and setting of C 3 S paste without the need of taking the sintering step.…”

Section: Introductionmentioning

confidence: 99%

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Low-temperature fabrication of macroporous scaffolds through foaming and hydration of tricalcium silicate paste and their bioactivity

2010

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A low-temperature fabrication method for highly porous bioactive scaffolds was developed. The twostep method involved the foaming of tricalcium silicate cement paste and hydration to form calcium silicate hydrate and calcium hydroxide. Scaffolds with a combination of interconnected macro-and micro-sized pores were fabricated by making use of the decomposition of a hydrogen peroxide (H 2 O 2 ) solution that acted as a foaming agent and through the hydration of tricalcium silicate cement. It was found possible to control the porosity and pore sizes by adjusting the concentration of the H 2 O 2 solution. The in vitro bioactivity of the highly porous scaffolds was investigated by immersion in simulated body fluid (SBF) for 7 days. Hydroxyapatite (HAp) was formed on the surface of the scaffolds. Their bioactivity could be expected to be as good as that of tricalcium silicate cement, making the material competent for the bone tissue engineering application.

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