The role of working memory and verbal fluency in autobiographical memory in early Alzheimer's disease and matched controls. Neuropsychologia, 78. pp. 115-121. ISSN 0028-3932.
Link to official URL (if available):http://dx.doi.org/10.1016/j.neuropsychologia. 2015.10.006 This version is made available in accordance with publishers' policies. All material made available by CReaTE is protected by intellectual property law, including copyright law. Any use made of the contents should comply with the relevant law.
AbstractRet rieval of aut obiographical memories (AMs) is import ant f or "sense of self ".Previous research and t heoret ical account s suggest t hat working memory (WM) and semant ic and phonemic f luency abilit ies f acilit at e t he hierarchical search f or, and reliving of past , personal event s in t he mind's eye. However, t here remains a lack of consensus as t o t he nat ure of t he relat ionships bet ween t hese cognit ive f unct ions and t he t ruly episodic aspect s of AM. The present st udy t heref ore aimed t o explore t he associat ions bet ween t hese variables in a sample wit h a wide range of cognit ive abilit ies. The st udy incorporat ed a bet ween-groups component , and a correlat ional component wit h mult iple regression. Part icipant s wit h Alzheimer's disease (n = 10) and mat ched healt hy cont rols (n = 10) were assessed on measures of semant ic and episodic AM search and ret rieval, audit ory and spat ial WM, and semant ic and phonemic f luency. The AD group produced less episodic AM cont ent compared t o cont rols. Semant ic f luency predict ed episodic AM ret rieval independent of age ef f ect s but t here were no signif icant relat ionships bet ween measures of phonemic f luency, WM and episodic AM. The result s suggest t hat t he abilit y t o maint ain hierarchical search of t he semant ic knowledge-base is import ant f or t ruly episodic reliving, and int ervent ions f or people wit h AM impairment might t heref ore benef it f rom incorporat ing st ruct ured, individualised ext ernal memory-aids t o f acilit at e AM search and ret rieval. allow f or t he measurement of "ment al t ime t ravel" t hat must occur f or t he t ruly episodic reliving of phenomenological det ails (Mat uszewski et al. , 2006). This is a key limit at ion because it is possible t hat previous associat ions t hought t o occur bet ween execut ive f unct ion or WM and episodic reliving may act ually be 5
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WORKING MEMORY AND VERBAL FLUENCY IN AUTOBIOGRAPHICAL MEMORYrelat ionships wit h semant ic rat her t han episodic AM. This issue is f urt her complicat ed by result s suggest ing a role f or MTL-mediat ed episodic memory in semant ic f luency t asks. For example, Sheldon and Moscovit ch (2012) have demonst rat ed t hat inherent ly aut obiographical semant ic f luency t asks (e. g. "names of f riends") recruit MTL st ruct ures compared t o closed-ended semant ic f luency t asks requiring lit t le spat ial or cont ext ual inf ormat ion (e. g. "t hings t hat are red"), but t hat t here was increa...