The selenoprotein methionine sulfoxide reductase B1 (MSRB1)

Tarrago, Lionel; Kaya, Alaattin; Kim, Hwa-Young; Manta, Bruno; Lee, Byung-Cheon; Gladyshev, Vadim N.

doi:10.1016/j.freeradbiomed.2022.08.043

Cited by 19 publications

(22 citation statements)

References 146 publications

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“…MSRB1 is responsible for reducing methionine sulfoxide (MetO) to methionine (Met). It supports a wide variety of cellular functions and recent reports elucidated a role for MSRB1 in the innate immune response [ 56 ]. The DIOs collectively regulate thyroid hormone activity [ 57 ].…”

Section: Overview Of Selenium In Biological Functionsupporting

confidence: 61%

Selenium in Bodily Homeostasis: Hypothalamus, Hormones, and Highways of Communication

Toh

Nicholson

Vetter

et al. 2022

IJMS

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The ability of the body to maintain homeostasis requires constant communication between the brain and peripheral tissues. Different organs produce signals, often in the form of hormones, which are detected by the hypothalamus. In response, the hypothalamus alters its regulation of bodily processes, which is achieved through its own pathways of hormonal communication. The generation and transmission of the molecules involved in these bi-directional axes can be affected by redox balance. The essential trace element selenium is known to influence numerous physiological processes, including energy homeostasis, through its various redox functions. Selenium must be obtained through the diet and is used to synthesize selenoproteins, a family of proteins with mainly antioxidant functions. Alterations in selenium status have been correlated with homeostatic disturbances in humans and studies with animal models of selenoprotein dysfunction indicate a strong influence on energy balance. The relationship between selenium and energy metabolism is complicated, however, as selenium has been shown to participate in multiple levels of homeostatic communication. This review discusses the role of selenium in the various pathways of communication between the body and the brain that are essential for maintaining homeostasis.

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Section: Overview Of Selenium In Biological Functionsupporting

confidence: 61%

Selenium in Bodily Homeostasis: Hypothalamus, Hormones, and Highways of Communication

Toh

Nicholson

Vetter

et al. 2022

IJMS

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“…A higher Se transfer to eggs was observed when OH-SeMet was compared to SS ( Zorzetto et al, 2021 ), and also when compared to SY ( Jlali et al 2013 ). This generates a greater antioxidant capacity for the bird – as previously pointed out – and for the eggs themselves, thus ensuring not only higher quality eggs for longer storage periods – justified by the increased presence of selenoprotein MsrB1 ( Tarrago et al 2022 ) which promotes lower oxidation of egg protein – but also Se-rich eggs.…”

Section: Discussionmentioning

confidence: 77%

Hydroxy-selenomethionine enhances the productivity and egg quality of 50- to 70-week-old semi-heavy laying hens under heat stress

Brito

Kaneko²,

Cavalcante³

et al. 2023

Poultry Science

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“…Lastly, as described above, the sites that the MICALs modify on actin (Met44 and/or Met47) have been linked to different diseases, including nemaline myopathy, CAP myopathy, aortic aneurisms, hypertrophic cardiomyopathy, intestinal hypoperistalsis, Baraitser-Winter cerebrofrontofacial syndrome, and ductus arteriosus (Laing et al, 2009;Hung et al, 2010b;Hoffjan et al, 2011;Zou et al, 2013;Regalado et al, 2014;Wangler et al, 2014;Yates et al, 2017;Zhang et al, 2019). It is also worth considering that some of the defects associated with mutations in the family of enzymes that reverse the MICAL's effects, MsrBs/SelR's, may result from increased effects of the MICALs on F-actin [see (Tarrago et al, 2022) for coverage of those defects].…”

Section: Figurementioning

confidence: 99%

MICAL-mediated oxidation of actin and its effects on cytoskeletal and cellular dynamics

Rajan

Terman

Reisler

2023

Front. Cell Dev. Biol.

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Actin and its dynamic structural remodelings are involved in multiple cellular functions, including maintaining cell shape and integrity, cytokinesis, motility, navigation, and muscle contraction. Many actin-binding proteins regulate the cytoskeleton to facilitate these functions. Recently, actin’s post-translational modifications (PTMs) and their importance to actin functions have gained increasing recognition. The MICAL family of proteins has emerged as important actin regulatory oxidation-reduction (Redox) enzymes, influencing actin’s properties both in vitro and in vivo. MICALs specifically bind to actin filaments and selectively oxidize actin’s methionine residues 44 and 47, which perturbs filaments’ structure and leads to their disassembly. This review provides an overview of the MICALs and the impact of MICAL-mediated oxidation on actin’s properties, including its assembly and disassembly, effects on other actin-binding proteins, and on cells and tissue systems.

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The selenoprotein methionine sulfoxide reductase B1 (MSRB1)

Cited by 19 publications

References 146 publications

Selenium in Bodily Homeostasis: Hypothalamus, Hormones, and Highways of Communication

Selenium in Bodily Homeostasis: Hypothalamus, Hormones, and Highways of Communication

Hydroxy-selenomethionine enhances the productivity and egg quality of 50- to 70-week-old semi-heavy laying hens under heat stress

MICAL-mediated oxidation of actin and its effects on cytoskeletal and cellular dynamics

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