The selenium-containing compound 3-((4-chlorophenyl)selanyl)-1-methyl-1H-indole reverses depressive-like behavior induced by acute restraint stress in mice: modulation of oxido-nitrosative stress and inflammatory pathway

Casaril, Angela Maria; Domingues, Micaela; Bampi, Suely Ribeiro; Lourenço, Darling de Andrade; Padilha, Nathalia B.; Lenardão, Eder J.; Sonego, Mariana Souza; Seixas, Fabiana Kömmling; Collares, Tiago; Nogueira, Cristina Wayne; Dantzer, Robert; Savegnago, Lucielli

doi:10.1007/s00213-018-5151-x

Cited by 45 publications

(36 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the same way, the antidepressant-like effect elicited by CMI has been already shown by our research group. These studies demonstrated the antidepressant-like effect of CMI in the inflammatory model and acute restraint stress model (Casaril et al, 2017 , 2019a ). The persistent investigation of new molecules to depressive symptoms is necessary because the depression precipitated by stress occurs in the general population (Yang et al, 2015 ).…”

Section: Discussionmentioning

confidence: 94%

“…Other studies demonstrated that CMI treatment regulates the oxidative stress, for example, acute treatment with CMI reversed oxidative stress in the prefrontal cortices and hippocampi of mice subjected to acute restraint stress (Casaril et al, 2019a ); CMI pre-treatment prevented RS production induced by lipopolysaccharide in cerebral cortex of mice (Casaril et al, 2017 ); Birmann et al ( 2019 ) show that CMI also decreased the levels of RS and lipid peroxidation in frontal cortices and hippocampi and plasma levels of corticosterone in mice presenting depressive-like behavior induced by partial sciatic nerve ligation.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Short- and Long-Term Repeated Forced Swim Stress Induce Depressive-Like Phenotype in Mice: Effectiveness of 3-[(4-Chlorophenyl)Selanyl]-1-Methyl-1H-Indole

Pesarico

Birmann

Pinto

et al. 2020

Front. Behav. Neurosci.

Self Cite

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Short- and Long-Term Repeated Forced Swim Stress Induce Depressive-Like Phenotype in Mice: Effectiveness of 3-[(4-Chlorophenyl)Selanyl]-1-Methyl-1H-Indole

Pesarico

Birmann

Pinto

et al. 2020

Front. Behav. Neurosci.

Self Cite

View full text Add to dashboard Cite

“…[ 9,10,21 ] The well‐known open field, forced swimming, tail suspension and tail suspension test are used to assess the depression‐like behaviour of mice, and the marble burying and elevated plus maze tests are used to evaluate their anxiety‐like behaviour. [ 10,22–24 ] By exposing mice to ARS and conducting the forced swimming test and tail suspension test, we found that immobility duration and grooming time increased, respectively. The mice subjected to ARS treatment showed increased number of buried marbles in the marble burying test and spend less time on the open arms in the elevated plus maze test.…”

Section: Discussionmentioning

confidence: 99%

e5NT inhibitor protects acute restraint stress-induced depression by regulating nucleoside release in mice

Liu

Zhu

Zhou

et al. 2020

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

Objectives To determine whether ecto-5 0-nucleotidase (e5NT) contributes to the release of adenosine and uridine and whether is establishes the role of e5NT in acute restraint stress-induced depression and anxiety-like behaviours in mice. Methods Acute restraint stress was induced to detect the level of nucleoside in the hippocampus. Mouse hippocampal brain proteins were isolated and subjected to Western blotting (WB) experiments to examine the protein expression levels of proteins that affect nucleoside release. Adenosine 5 0-(a,b-methylene) diphosphate (APCP), an e5NT inhibitor, was intraventricularly injected to investigate the regulatory effect of e5NT on nucleoside levels and behavioural changes caused by acute restraint stress in mice. Key findings Acute restraint stress increased the level of extracellular adenosine and uridine levels in the hippocampus of mice and significantly increased the expression of extracellular nucleoside-metabolizing enzymes were significantly increased. By administering APCP, the increase in adenosine and uridine levels caused by acute restraint stress could be suppressed. APCP inhibited behavioural changes, which were induced by acute restraint stress. Conclusions These data suggest that acute restraint stress may alter extracellular adenosine and uridine levels content in the hippocampus of mice via e5NT, and thus, the inhibition of e5NT may improve the anxiety behaviour in mice. Therefore, e5NT may therefore be a potential therapeutic target for the treatment of anxiety in mice.

show abstract

“…Several other selenocompounds have shown promising effects in stressed mice. Casaril et al (2019) showed that 3-((4-chlorophenyl)selanyl)-1-methyl-1H-indole (CMI) can prevent ARS-induced depressive-like behavior in mice without affecting non-stressed subjects. Originally developed to combat atherosclerosis-associated inflammation by protecting extracellular matrix proteins from oxidative stress, CMI induces antinociceptive effects in mice by modulating serotonergic activity (Casaril et al, 2017b) and can reverse the depressive-like phenotype caused by lipopolysaccharide injection (Casaril et al, 2017a).…”

Section: Selenium and Glucocorticoid Action In The Brainmentioning

confidence: 99%

Stress and the Brain: An Emerging Role for Selenium

2021

View full text Add to dashboard Cite

The stress response is an important tool in an organism’s ability to properly respond to adverse environmental conditions in order to survive. Intense acute or chronic elevation of glucocorticoids, a class of stress hormone, can have deleterious neurological effects, however, including memory impairments and emotional disturbances. In recent years, the protective role of the antioxidant micronutrient selenium against the negative impact of externally applied stress has begun to come to light. In this review, we will discuss the effects of stress on the brain, with a focus on glucocorticoid action in the hippocampus and cerebral cortex, and emerging evidence of an ability of selenium to normalize neurological function in the context of various stress and glucocorticoid exposure paradigms in rodent models.

show abstract

The selenium-containing compound 3-((4-chlorophenyl)selanyl)-1-methyl-1H-indole reverses depressive-like behavior induced by acute restraint stress in mice: modulation of oxido-nitrosative stress and inflammatory pathway

Cited by 45 publications

References 73 publications

Short- and Long-Term Repeated Forced Swim Stress Induce Depressive-Like Phenotype in Mice: Effectiveness of 3-[(4-Chlorophenyl)Selanyl]-1-Methyl-1H-Indole

Short- and Long-Term Repeated Forced Swim Stress Induce Depressive-Like Phenotype in Mice: Effectiveness of 3-[(4-Chlorophenyl)Selanyl]-1-Methyl-1H-Indole

e5NT inhibitor protects acute restraint stress-induced depression by regulating nucleoside release in mice

Stress and the Brain: An Emerging Role for Selenium

Contact Info

Product

Resources

About