The select of internal architecture for porous Ti alloy scaffold: A compromise between mechanical properties and permeability

Yu, Guisheng; Li, Zhibin; Li, Shuangjian; Zhang, Qiang; Hua, Youlu; Liu, Hui; Zhao, Xueyang; Dhaidhai, Denzel Tafuma; Li, Wei; Wang, Xiaojian

doi:10.1016/j.matdes.2020.108754

Cited by 95 publications

(37 citation statements)

References 51 publications

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“…Another problem should be considered in orthopedics is stress-shielding, which is usually caused by the over-high Young's modulus of the implants [ 70 ]. A porous structure design is helpful for reducing the stiffness of the implants [ 71 ]. Besides, the biodegradation process would also decrease the mechanical strength gradually, leaving essential stress for the bone to restore to its own strength.…”

Section: Discussionmentioning

confidence: 99%

Biodegradable ZnLiCa ternary alloys for critical-sized bone defect regeneration at load-bearing sites: In vitro and in vivo studies

Zhang

Jia

Yang

et al. 2021

Bioactive Materials

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A novel biodegradable metal system, ZnLiCa ternary alloys, were systematically investigated both in vitro and in vivo . The ultimate tensile strength (UTS) of Zn0.8Li0.1Ca alloy reached 567.60 ± 9.56 MPa, which is comparable to pure Ti, one of the most common material used in orthopedics. The elongation of Zn0.8Li0.1Ca is 27.82 ± 18.35%, which is the highest among the ZnLiCa alloys. The in vitro degradation rate of Zn0.8Li0.1Ca alloy in simulated body fluid (SBF) showed significant acceleration than that of pure Zn. CCK-8 tests and hemocompatibility tests manifested that ZnLiCa alloys exhibit good biocompatibility. Real-time PCR showed that Zn0.8Li0.1Ca alloy successfully stimulated the expressions of osteogenesis-related genes (ALP, COL-1, OCN and Runx-2), especially the OCN. An in vivo implantation was conducted in the radius of New Zealand rabbits for 24 weeks, aiming to treat the bone defects. The Micro-CT and histological evaluations proved that the regeneration of bone defect was faster within the Zn0.8Li0.1Ca alloy scaffold than the pure Ti scaffold. Zn0.8Li0.1Ca alloy showed great potential to be applied in orthopedics, especially in the load-bearing sites.

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Section: Discussionmentioning

confidence: 99%

Biodegradable ZnLiCa ternary alloys for critical-sized bone defect regeneration at load-bearing sites: In vitro and in vivo studies

Zhang

Jia

Yang

et al. 2021

Bioactive Materials

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“…The gyroid scaffolds have a higher compressive and tensile strength than the BCC scaffolds. On the other side, the permeability of the gyroid scaffolds, deciding on biological transport, is much lower than that of the BCC ones [154]. As concerns the biological behavior, for both types of unit cells, octahedron, and tetrahedron, cells spread better and displayed more filopodia on scaffolds with greater pore size, but cell proliferation was superior in the octahedral unit cell [71].…”

Section: Effects Of Manufacturing Errors On Properties Of Ti Scaffoldsmentioning

confidence: 98%

Structural and Material Determinants Influencing the Behavior of Porous Ti and Its Alloys Made by Additive Manufacturing Techniques for Biomedical Applications

Dziaduszewska

Zieliński

2021

Materials

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One of the biggest challenges in tissue engineering is the manufacturing of porous structures that are customized in size and shape and that mimic natural bone structure. Additive manufacturing is known as a sufficient method to produce 3D porous structures used as bone substitutes in large segmental bone defects. The literature indicates that the mechanical and biological properties of scaffolds highly depend on geometrical features of structure (pore size, pore shape, porosity), surface morphology, and chemistry. The objective of this review is to present the latest advances and trends in the development of titanium scaffolds concerning the relationships between applied materials, manufacturing methods, and interior architecture determined by porosity, pore shape, and size, and the mechanical, biological, chemical, and physical properties. Such a review is assumed to show the real achievements and, on the other side, shortages in so far research.

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“…Different computational studies have given emphasis to distinct mechanical properties, all of which are important in creating a functional BTE scaffold. The two mechanical parameters of a scaffold that are regularly examined are its compressive strength [48,49,54,56] and Young's modulus [48–52,54–56,58]. Any scaffold meant for an in vivo application needs to have an appropriate compressive strength and Young's modulus providing the required mechanical support to the implantation site, without resulting in a large loss of bone mass due to stress shielding.…”

Section: Beyond Cfdmentioning

confidence: 99%

Challenges in computational fluid dynamics applications for bone tissue engineering

et al. 2022

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Bone injuries or defects that require invasive surgical treatment are a serious clinical issue, particularly when it comes to treatment success and effectiveness. Accordingly, bone tissue engineering (BTE) has been researching the use of computational fluid dynamics (CFD) analysis tools to assist in designing optimal scaffolds that better promote bone growth and repair. This paper aims to offer a comprehensive review of recent studies that use CFD analysis in BTE. The mechanical and fluidic properties of a given scaffold are coupled to each other via the scaffold architecture, meaning an optimization of one may negatively affect the other. For example, designs that improve scaffold permeability normally result in a decreased average wall shear stress. Linked with these findings, it appears there are very few studies in this area that state a specific application for their scaffolds and those that do are focused on in vitro bioreactor environments. Finally, this review also demonstrates a scarcity of studies that combine CFD with optimization methods to improve scaffold design. This highlights an important direction of research for the development of the next generation of BTE scaffolds.

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The select of internal architecture for porous Ti alloy scaffold: A compromise between mechanical properties and permeability

Cited by 95 publications

References 51 publications

Biodegradable ZnLiCa ternary alloys for critical-sized bone defect regeneration at load-bearing sites: In vitro and in vivo studies

Biodegradable ZnLiCa ternary alloys for critical-sized bone defect regeneration at load-bearing sites: In vitro and in vivo studies

Structural and Material Determinants Influencing the Behavior of Porous Ti and Its Alloys Made by Additive Manufacturing Techniques for Biomedical Applications

Challenges in computational fluid dynamics applications for bone tissue engineering

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