The sedative effects of intramuscular low-dose medetomidine in combination with butorphanol or methadone in dogs

Puighibet, Zoë; Costa‐Farré, Cristina; Santos, Luiz Carlos Oliveira dos; Canfrán, Susana; Segura, Ignacio A. Gómez de

doi:10.1111/vaa.12256

Cited by 15 publications

(19 citation statements)

References 21 publications

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“…Many literatures suggested that BTR has minimal cardiovascular and respiratory effects, but when administered with α2 agonists it increases their depressant effect on heart and respiratory rates (Trim, 1983, Ko, et al, 2000, Sinclair, 2003 also bradycardiac effects of α2 agonists and butorphanol appeared to be additive (Bartram et al 1994). We proved here in our study that the DTM have the same side effects of MDM and DXM when combined with BTR (Bartram, et al, 1994, Grimm et al, 2000, Ko, et al 2000, Leppanen et al, 2006, Salla et al, 2014, Puighibet et al, 2015, Lee et al, 2016, Tamura et al, 2016.…”

Section: Resultssupporting

confidence: 67%

“…The common form of α2 agonist in pet clinics, medetomidine (MDM) showed similar effect when combined with BTR and the author's stated that MDM-BTR could be enough for sedation of dogs to perform various clinical procedures (Bartram et al 1994). The MDM and its dextro-isomer (dexmedetomidine) (DXM) also has been previously used in similar studies (Bartram et al, 1994, Grimm et al, 2000, Ko et al, 2000, Leppanen et al, 2006, Salla et al, 2014, Puighibet et al, 2015, Lee et al, 2016, Tamura et al, 2016. The same combination in other animal species also proved to be efficient for sedation and antinociception like in equine (Joubert et al, 1999, Abu-Ahmed, 2007 and in ruminant (Carroll et al, 1998, Lin andRiddell, 2003).…”

Section: Resultsmentioning

confidence: 98%

“…The most common and available analgesics nowadays are nalbuphine and butorphanol which classified as agonistantagonist opioids similar to morphine and are likely to produce sedation and analgesia (Jaff and Martin, 1985;Pascoe, 2000). Butorphanol was evaluated for its potentiating anesthetic effect in combination with sedatives (Salla et al, 2014;Kellihan et al, 2015, Puighibet et al, 2015Lee et al, 2016, Tamura et al, 2016 and tranquilizers (Seo et al, 2015). Nalbuphine has been suggested as a good component to provide balanced anesthesia ( Crul et al, 1990;Kothari and Sharma, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Comparison of the Antinociceptive Potentiating Effect of Two Opioids when Combined with Detomidine or Diazepam in Dogs

Abu-Ahmed¹

2017

AJVS

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Key words:Balanced anesthesia, detomidine, nalbuphine, butorphanol, dog.The continuous search for suitable and effective drug combination for dog sedation and analgesia is an aim for most of researchers. The current experimental study aimed to evaluate and compare the sedative, analgesic and cardiorespiratory effects of detomidine/butorphanol, detomidine/nalbuphine, diazepam/butorphanol and diazepam/nalbuphine combinations in sex healthy mongrel dogs. Detomidinebutorphanol or nalbuphine resulted in deep degree of sedation and a reliable period of intense antinociceptive effect. The Longest period of sedation was recorded post diazepam-butorphanol injection. However, diazepam-nalbuphine resulted in the shortest period of both sedation and antinociception. Significant reduction of pulse and respiratory rates was observed post detomidine-opioids combination while diazepamopioids combination resulted in minimal cardiorespiratory effect. It could be concluded that detomidine-butorphanol induced a strong preemptive antinociceptive effect and a state of balanced anesthesia with minimal response to noxious stimulation.

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Section: Resultssupporting

confidence: 67%

Section: Resultsmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Comparison of the Antinociceptive Potentiating Effect of Two Opioids when Combined with Detomidine or Diazepam in Dogs

Abu-Ahmed¹

2017

AJVS

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“…In veterinary medicine, α-2 receptor agonists are usually combined with opioids, such as methadone, to potentiate their analgesic and sedative effects via a synergistic effect, without important alterations in cardiorespiratory variables (Cardoso, Marques, Silva, & Mattos-Junior, 2014;Monteiro, Figueroa, Choma, Campagnol, & Bettini, 2008;Puighibet, Costa-Farré, Santos, Canfràn, & Gomez de Segura, 2015). In fact, synergism between α-2 receptor agonists and opioids is well-recognized because they use the same signal transduction system (G-protein activation) and have partly overlapping central receptor localization (Murrell & Hellebrekers, 2005).…”

Section: Introductionmentioning

confidence: 99%

Clinical pharmacokinetics of a dexmedetomidine–methadone combination in dogs undergoing routine anaesthesia after buccal or intramuscular administration

Cesare

Gioeni

Ravasio

et al. 2019

Vet Pharm & Therapeutics

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This study aimed to define the pharmacokinetic profiles of dexmedetomidine and methadone administered simultaneously in dogs by either an oral transmucosal route or intramuscular route and to determine the bioavailability of the oral transmucosal administration relative to the intramuscular one of both drugs, so as the applicability of this administration route in dogs. Twelve client‐owned dogs, scheduled for diagnostic procedures, were treated with a combination of dexmedetomidine hydrochloride (10 μg/kg) and methadone hydrochloride (0.4 mg/kg) through an oral transmucosal route or intramuscularly. Oral transmucosal administration caused ptyalism in most subjects, and intramuscular administration caused transient peripheral vasoconstriction. The results showed reduced and delayed absorption of both dexmedetomidine and methadone when administered through an oral transmucosal route, with median (range) Cmax values of 0.82 (0.42–1.49) ng/ml and 13.22 (2.80–52.30) ng/ml, respectively. The relative bioavailability was low: 16.34% (dexmedetomidine) and 15.5% (methadone). Intramuscular administration resulted in a more efficient absorption profile, with AUC and Cmax values for both drugs approximately 10 times higher. Dexmedetomidine and methadone administered simultaneously by an oral transmucosal route using injectable formulations were not well absorbed through the oral mucosa. Nevertheless, additional studies on these drugs combination using alternative administration routes are recommended.

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“…The dogs were sedated using intramuscular injections of 0.4 mg/kg butorphanol (Vetorphal, Meiji Seika Pharma Co., Ltd., Tokyo, Japan) and 2.5 µg/kg medetomidine (Domitor, Nippon Zenyaku Kogyo Co., Ltd., Fukushima, Japan) in the femoral region to facilitate sufficient imaging doi: 10.1292/jvms.19-0515 time. Additionally, this sedation could be reversed quickly using antagonist agents if necessary [7]. The dogs were positioned in sternal recumbency.…”

mentioning

confidence: 99%

Pharyngeal contraction secondary to its collapse in dogs with brachycephalic airway syndrome

et al. 2020

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Brachycephalic airway syndrome (BAS) is a common disease in certain "flat-faced" dog breeds. This syndrome includes stenotic nares, elongated and thickened soft palate, laryngeal collapse, and tracheal hypoplasia. Pharyngeal collapse is also commonly observed, but it is unclear if laryngopharynx motions are merely sequelae or actually contribute to BAS respiratory symptoms. Laryngopharynx motion was imaged using dynamic four-dimensional computed tomography (4D-CT) during spontaneous respiration in four dogs with different BAS types. Dynamic 4D-CT showed laryngopharynx motion in the following order during inspiration: pharyngeal collapse, contraction, and laryngospasm. We concluded that dynamic 4D-CT is a highly-detailed diagnostic approach for detecting laryngopharynx motion. Pharyngeal contraction during inspiration appears to contribute toward the worsening of clinical respiratory signs of BAS.

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The sedative effects of intramuscular low-dose medetomidine in combination with butorphanol or methadone in dogs

Cited by 15 publications

References 21 publications

Comparison of the Antinociceptive Potentiating Effect of Two Opioids when Combined with Detomidine or Diazepam in Dogs

Comparison of the Antinociceptive Potentiating Effect of Two Opioids when Combined with Detomidine or Diazepam in Dogs

Clinical pharmacokinetics of a dexmedetomidine–methadone combination in dogs undergoing routine anaesthesia after buccal or intramuscular administration

Pharyngeal contraction secondary to its collapse in dogs with brachycephalic airway syndrome

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