The Second International Conference on Sentinel Node Biopsy in Mucosal Head and Neck Cancer

Stoeckli, Sandro J.; Pfaltz, Madeleine; Ross, Gary; Steinert, H.; MacDonald, D.G.; Wittekind, Christian; Soutar, David S.

doi:10.1245/aso.2005.11.024

Cited by 140 publications

(94 citation statements)

References 23 publications

(27 reference statements)

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“…Identification of SLN is done by radio colloid alone, blue dye alone or combination of both radio colloid and blue dye. Studies have shown identification rate of 97 % (range 90-100 %), negative predictive value of 96 % (range 88-100 %) [5]. There are very limited studies where they have used only blue dye to identify SLN.…”

Section: Introductionmentioning

confidence: 99%

Sentinel Lymph Node Biopsy in N0 Neck for Squamous Cell Carcinoma of Oral Cavity: a Prospective Study

Shivakumar

Goel

Manjunath

et al. 2016

Indian J Surg Oncol

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Oral cancers in India are very common. SLNB (sentinel lymph node biopsy) for the management of the cN0 neck provides proper staging with less morbidity. The study aims at assessment of the technical feasibility and accuracy of SLNB. Two by two table and Kappa statistic was used to compare SLN and END. In 14 cases out of 16 cases, SLN was identified. Sensitivity and specificity of 100 % were found. One hundred percent agreement was observed between SLN and END using kappa statistics. A meta-analysis of 19 studies showed 97.7 % sentinel node identification rate and 92.6 % sensitivity with a false negative rate of 3 %. In patients with N0 neck and negative SLN, neck dissection can be avoided decreasing morbidity of SOND. SLN biopsy has potential to become standard of care for managing N0 neck; however, long-term oncological results need to be evaluated.

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Section: Introductionmentioning

confidence: 99%

Sentinel Lymph Node Biopsy in N0 Neck for Squamous Cell Carcinoma of Oral Cavity: a Prospective Study

Shivakumar

Goel

Manjunath

et al. 2016

Indian J Surg Oncol

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“…To clarify a potential prognostic relevance for occult metastasis of SOX2 protein expression, we consequently analysed a very well defined patient cohort with early oral SCC (T1/T2-stage) undergoing sentinel lymph node biopsy. 16,17 …”

Section: Introductionmentioning

confidence: 99%

High sex determining region Y-box 2 expression is a negative predictor of occult lymph node metastasis in early squamous cell carcinomas of the oral cavity

Züllig

Roessle

Weber

et al. 2013

European Journal of Cancer

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“…; ipsilateral). Here it is shown to be quite sensitive at 97% on average (range: 96-100%); however, there is still a small false negative rate (average 4%, range: 0-12%) [18][19][20]. Potential explanations for this are skip metastases and 'masking' of a sentinel node by adjacent radiotracer uptake from carcinomas of the floor of mouth particularly in level I.…”

Section: Sentinel Nodesmentioning

confidence: 80%

“…Nonetheless, it is currently used in lieu of elective neck dissection in select cases at several institutions. The recommended indications for SLNB as proposed by 'The Second International Conference on Sentinel Node Biopsy in Mucosal Head and Neck Cancer' [18] are as follows: (1) staging of the ipsilateral neck in unilateral cT1/2 cN0 tumors, (2) staging of the ipsilateral and contralateral neck in midline tumors or tumors crossing the midline (cT1/2 cN0), and (3) staging of the contralateral neck in midline tumors or tumors crossing the midline (cT1/2 cN? ; ipsilateral).…”

Section: Sentinel Nodesmentioning

confidence: 99%

Current State of Neck Dissection in the United States

Seethala

2009

Head and Neck Pathol

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The status of the cervical lymph nodes is the most important prognosticator in head and neck squamous cell carcinoma. The neck dissection is both a therapeutic and staging procedure and has evolved to include various types with standardized level designations (I-VI) for lymph node groups: the radical neck dissection, modified radical neck dissection, the selective neck dissection, and the extended neck dissection. The gross and histologic examination of a neck dissection should provide the critical information (size of metastasis, number of lymph nodes involved) for staging purposes. Additionally, extracapsular spread of lymph node metastasis must be reported because of its significance as an adverse prognosticator. Current dilemmas in nodal disease are the detection of micrometastases, isolated tumor cells, and molecular positivity. The significance of these categories of disease is still unclear, though they may explain a subset of the estimated 10% of the regional recurrences in the neck despite pathologic node negativity by traditional methods of evaluation. Sentinel lymph node biopsy has been recently applied to head and neck squamous cell carcinoma to enhance the management of the clinicoradiographically node negative patients. While still investigational, sentinel lymph node biopsy shows promise in selecting patients who require a neck dissection. Rapid highly automated real-time RT-PCR based platforms will allow for incorporation of molecular findings into the intraoperative evaluation of a sentinel lymph node.

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The Second International Conference on Sentinel Node Biopsy in Mucosal Head and Neck Cancer

Cited by 140 publications

References 23 publications

Sentinel Lymph Node Biopsy in N0 Neck for Squamous Cell Carcinoma of Oral Cavity: a Prospective Study

Sentinel Lymph Node Biopsy in N0 Neck for Squamous Cell Carcinoma of Oral Cavity: a Prospective Study

High sex determining region Y-box 2 expression is a negative predictor of occult lymph node metastasis in early squamous cell carcinomas of the oral cavity

Current State of Neck Dissection in the United States

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