2000
DOI: 10.1177/026119290002800603
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The Second ECVAM Workshop on Phototoxicity Testing

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Cited by 48 publications
(4 citation statements)
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“…Since March 2009 chemically-induced phototoxicity has had to be studied only in vitro. For this purpose, a validated test based on neutral red uptake by 3T3 fibroblasts in culture after exposure to solar UV or UVA in the presence of the chemical to be studied (3T3 NRU test 29 ) has been developed. In order to better characterize phototoxicity, many efforts have been made to develop screening strategies involving reconstructed epidermis in addition to 3T3 NRU assay.…”
Section: Introductionmentioning
confidence: 99%
“…Since March 2009 chemically-induced phototoxicity has had to be studied only in vitro. For this purpose, a validated test based on neutral red uptake by 3T3 fibroblasts in culture after exposure to solar UV or UVA in the presence of the chemical to be studied (3T3 NRU test 29 ) has been developed. In order to better characterize phototoxicity, many efforts have been made to develop screening strategies involving reconstructed epidermis in addition to 3T3 NRU assay.…”
Section: Introductionmentioning
confidence: 99%
“…For this purpose, different symposia, meetings and workshops have been organized since 1993, by the European Center for the Validation of Alternative Methods in 1993 (3) and 1999 (4) in Europe, in 1996 by the Food and Drug Administration (5) and in 1999 (International Workshop of Genotoxicity Test Procedures, IWGTP, Washington) (6), to address this question and evaluate the existing in vitro methodology. No regulatory requirement has been specified, but a set of recommendations and guidances have been issued (4–6). Until now, the photocytotoxicity test 3T3 neutral red uptake (NRU) is the only in vitro method that has been validated so far by European regulatory affairs (7–9).…”
Section: Introductionmentioning
confidence: 99%
“…There are hundreds of cannabinoid receptors agonists with varying affinities for CB1 that can be used as potential targets for addictive drugs [31]. In this study, we investigated whether the synthetic cannabinoid JWH-210, which has a high affinity for CB1, increases the dependence liability of other abused drugs, such as methamphetamine (METH) [32]. In addition, we also investigated how CB1 agonist affects neurotransmitters, such as dopamine, which are involved in impulsive behaviors and psychological dependence that may result from substance abuse.…”
Section: Introductionmentioning
confidence: 99%