The search for novel treatment strategies for<i>Streptococcus pneumoniae</i>infections

Cools, Freya; Delputte, Peter; Cos, Paul

doi:10.1093/femsre/fuaa072

Cited by 13 publications

(10 citation statements)

References 255 publications

(215 reference statements)

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“…It would be useful to identify potential new drug targets and to improve infection outcomes; the strategies to achieve this goal, each with benefits and limitations, could be boosting host immunity by interfering with its immune responses, lowering pneumococcal virulence, and developing novel antibacterial with a new mechanism of action. More research is needed in this field [ 63 ].…”

Section: Therapeutic Optionmentioning

confidence: 99%

Pneumonia and Invasive Pneumococcal Diseases: The Role of Pneumococcal Conjugate Vaccine in the Era of Multi-Drug Resistance

et al. 2021

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Streptococcus pneumoniae related diseases are a leading cause of morbidity and mortality, especially in children and in the elderly population. It is transmitted to other individuals through droplets and it can spread to other parts of the human host, causing a wide spectrum of clinical syndromes, affecting between 10 and 100 cases per 100,000 people in Europe and the USA. In order to reduce morbidity and mortality caused by this agent, pneumococcal vaccines have been developed over the years and have shown incredible effectiveness in reducing the spread of this bacterium and the development of related diseases, obtaining a significant reduction in mortality, especially in developing countries. However, considerable problems are emerging mainly due to the replacement phenomenon, multi-drug resistance, and the high production costs of conjugated vaccines. There is still a debate about the indications given by various countries to different age groups; this is one of the reasons for the diffusion of different serotypes. To cope with these problems, significant efforts have been made in the research field to further improve vaccination serotypes coverage. On the other hand, an equally important commitment by health care systems to all age group populations is needed to improve vaccination coverage.

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Section: Therapeutic Optionmentioning

confidence: 99%

Pneumonia and Invasive Pneumococcal Diseases: The Role of Pneumococcal Conjugate Vaccine in the Era of Multi-Drug Resistance

et al. 2021

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“…Pneumococcal diseases Pneumococcal diseases are one of the major human respiratory pathogens that cause community-acquired pneumonia among people of all ages [ 165 ]. Microparticle-based diagnosis provides unprecedented opportunities for the treatment of these diseases.…”

Section: Micro/nanotechnology-based Diagnosis Methodsmentioning

confidence: 99%

Micro/nanotechnology-inspired rapid diagnosis of respiratory infectious diseases

et al. 2021

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Humans have suffered from a variety of infectious diseases since a long time ago, and now a new infectious disease called COVID-19 is prevalent worldwide. The ongoing COVID-19 pandemic has led to research of the effective methods of diagnosing respiratory infectious diseases, which are important to reduce infection rate and help the spread of diseases be controlled. The onset of COVID-19 has led to the further development of existing diagnostic methods such as polymerase chain reaction, reverse transcription polymerase chain reaction, and loop-mediated isothermal amplification. Furthermore, this has contributed to the further development of micro/nanotechnology-based diagnostic methods, which have advantages of high-throughput testing, effectiveness in terms of cost and space, and portability compared to conventional diagnosis methods. Micro/nanotechnology-based diagnostic methods can be largely classified into (1) nanomaterials-based, (2) micromaterials-based, and (3) micro/nanodevice-based. This review paper describes how micro/nanotechnologies have been exploited to diagnose respiratory infectious diseases in each section. The research and development of micro/nanotechnology-based diagnostics should be further explored and advanced as new infectious diseases continue to emerge. Only a handful of micro/nanotechnology-based diagnostic methods has been commercialized so far and there still are opportunities to explore.

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“…Quinolone antibiotics constitute the vast majority of the drugs listed in recent years ( Figure 2 ). These antibiotics are easy to modify and have simple and stable nuclei, broad-spectrum activity, and generally acceptable safety characteristics [ 7 ].…”

Section: Dna Topoisomerase Inhibitorsmentioning

confidence: 99%

A Comprehensive Overview of the Antibiotics Approved in the Last Two Decades: Retrospects and Prospects

et al. 2023

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Due to the overuse of antibiotics, bacterial resistance has markedly increased to become a global problem and a major threat to human health. Fortunately, in recent years, various new antibiotics have been developed through both improvements to traditional antibiotics and the discovery of antibiotics with novel mechanisms with the aim of addressing the decrease in the efficacy of traditional antibiotics. This manuscript reviews the antibiotics that have been approved for marketing in the last 20 years with an emphasis on the antibacterial properties, mechanisms, structure–activity relationships (SARs), and clinical safety of these antibiotics. Furthermore, the current deficiencies, opportunities for improvement, and prospects of antibiotics are thoroughly discussed to provide new insights for the design and development of safer and more potent antibiotics.

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The search for novel treatment strategies forStreptococcus pneumoniaeinfections

Cited by 13 publications

References 255 publications

Pneumonia and Invasive Pneumococcal Diseases: The Role of Pneumococcal Conjugate Vaccine in the Era of Multi-Drug Resistance

Pneumonia and Invasive Pneumococcal Diseases: The Role of Pneumococcal Conjugate Vaccine in the Era of Multi-Drug Resistance

Micro/nanotechnology-inspired rapid diagnosis of respiratory infectious diseases

A Comprehensive Overview of the Antibiotics Approved in the Last Two Decades: Retrospects and Prospects

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