The search for mechanisms of cognitive behavioral therapy for alcohol or other drug use disorders: A systematic review

Magill, Molly; Tonigan, J. Scott; Kiluk, Brian D.; Ray, Lara A.; Walthers, Justin; Carroll, Kathleen M.

doi:10.1016/j.brat.2020.103648

Cited by 46 publications

(39 citation statements)

References 47 publications

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“…The DMN has been suggested as a potential biomarker for substance-use risk and treatment response, and a treatment target for SUDs. 37 The identified 'craving network' might be utilized similarly, in particular for individuals who report high levels of craving; 60 for treatments that target craving, such as medication, 61 behavioral therapies including cognitive behavioral therapy, 62 mindfulness-based interventions, [63][64][65] and substance-use exposure; 66 and for novel, brain-based interventions such as neurofeedback targeting craving 67,68 and/or the DMN, 69,70 or targeting the 'craving network' directly. 71…”

Section: Discussionmentioning

confidence: 99%

Transdiagnostic connectome-based prediction of craving

Garrison

Sinha

Potenza

et al. 2021

Preprint

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Craving is a central construct in the study of motivation and human behavior and is also a clinical symptom of substance and non-substance-related addictive disorders. Thus, craving represents a target for transdiagnostic modeling. We applied connectome-based predictive modeling (CPM) to functional connectivity data in a large (N=274) transdiagnostic sample of individuals with and without substance-use-related conditions, to predict self-reported craving. CPM is a machine-learning approach used to identify neural signatures in functional connectivity data related to a specific phenotype. Functional connectomes were derived from three guided imagery conditions of personalized appetitive, stress, and neutral-relaxing experiences. Craving was rated before and after each imagery condition. CPM successfully predicted craving, thereby identifying a transdiagnostic craving network comprised primarily of the posterior cingulate cortex, hippocampus, visual cortex, and primary sensory areas. Findings suggest that craving may be associated with difficulties directing attention away from internal self-related processing, represented in the default mode network.

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Section: Discussionmentioning

confidence: 99%

Transdiagnostic connectome-based prediction of craving

Garrison

Sinha

Potenza

et al. 2021

Preprint

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“…This tool permits appraisal of the methodological quality of five categories of studies: qualitative research, randomized controlled trials, non-randomized studies, quantitative descriptive studies, and mixed methods studies. Additionally, for evaluating the quality of the evidence and risk of bias for statistical mediation in the included studies, the criteria from Magill et al (2020) will be used.…”

Section: Methodsmentioning

confidence: 99%

Mediators and Theories of Change in Psychotherapy for Young People With Personality Disorders: A Systematic Review Protocol

et al. 2021

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Background: Personality disorders (PDs) are a severe health issue already prevalent among adolescents and young adults. Early detection and intervention offer the opportunity to reduce disease burden and chronicity of symptoms and to enhance long-term functional outcomes. While psychological treatments for PDs have been shown to be effective for young people, the mediators and specific change mechanisms of treatment are still unclear.Aim: As part of the “European Network of Individualized Psychotherapy Treatment of Young People with Mental Disorders” (TREATme), funded by the European Cooperation in Science and Technology (COST), we will conduct a systematic review to summarize the existing knowledge on mediators of treatment outcome and theories of change in psychotherapy for young people with personality disorders. In particular, we will evaluate whether mediators appear to be common or specific to particular age groups, treatment models, or outcome domains (e.g., psychosocial functioning, life quality, and adverse treatment effects).Method: We will follow the reporting guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement recommendations. Electronic databases (PubMed and PsycINFO) have been systematically searched for prospective, longitudinal, and case–control designs of psychological treatment studies, which examine mediators published in English. Participants will be young people between 10 and 30years of age who suffer from subclinical personality symptoms or have a personality disorder diagnosis and receive an intervention that aims at preventing, ameliorating, and/or treating psychological problems.Results: The results will be published in a peer-reviewed journal and at conference presentations and will be shared with relevant stakeholder groups. The data set will be made available to other research groups following recommendations of the open science initiative. Databases with the systematic search will be made openly available following open science initiatives. The review has been registered in PROSPERO (evaluation is pending, registration number ID 248959).Implications: This review will deliver a comprehensive overview on the empirical basis to contribute to the further development of psychological treatments for young people with personality disorders.

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“…Consistent with recent reviews of mediators of CBT for adults with SUDs (Magill et al, 2020), each study included in the current review provided a theoretical rationale for their proposed mediator (s) (see Table 3). Slightly over half of the studies formally assessed mediation (53%) and only 35% used an established analytic technique, such as a test of the ab product (i.e., rather than a causal-steps approach) or the use of a nonnormal significance test (e.g., bootstrap confidence intervals), to test mediation.…”

Section: Mediation Study Quality Reviewmentioning

confidence: 98%

“…This review focuses broadly on treatments targeting adolescents with various levels of SU involvement (e.g., lifetime use, SU-related problems, and SUD) to be consistent with the one prior review and to reflect the shared underlying aim of these interventions (Black & Chung, 2014). Based on current recommendations for terminology and the broad levels of SU involvement targeted by adolescent SU treatments (Black & Chung, 2014; Kelly et al, 2016), we use the terminology SU throughout the manuscript rather than “misuse” or “SUD.” In line with recent recommendations for improving systematic reviews of treatment mediators, we organize our review using the classification system for MOBC put forth by the National Institutes of Health’s Science of Behavior Change (SOBC) program (Hagger et al, 2020; Magill et al, 2020; Nielsen et al, 2018). Further, we provide recommendations for advancing research on MOBC in adolescent SU treatment.…”

Section: Current Status Of Adolescent Substance Use Treatment Researchmentioning

confidence: 99%

Mechanisms of behavior change in adolescent substance use treatment: A systematic review of treatment mediators and recommendations for advancing future research.

Meisel¹,

Pielech²,

Magill³

et al. 2024

Clinical Psychology: Science and Practice

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Substance use disorders commonly onset during adolescence, yet the best available treatments yield only modest and transient effects. Elucidating treatment mediators is essential for improving treatment options. This review summarizes over 20 years of research on mediators of adolescent substance use treatment; k = 17 studies assessing both treatment or treatment ingredient to mediator (a path) and mediator to treatment outcome (b path) paths were included. Mediators were categorized using the Science of Behavior Change target class framework. Overall, mediation tests supported four of eight self-regulation, two of 10 stress resilience and reactivity, six of 19 interpersonal and social process, and two of four treatment engagement and adherence mediators. To enhance the capacity of this work to inform clinical practice, we recommend future research examine theoretically informed mechanisms using temporally sequenced data among other methodological guidelines. Public Health Significance StatementThe current study offers some support for self-regulatory and treatment engagement and adherence mediators of adolescent substance use treatment, however, heterogeneity in the sample of studies precludes any firm conclusions. A concerted effort to examine key processes of evidence-based adolescent substance use treatments can yield enhanced knowledge to guide practice, as well as intervention refinement and implementation within the community.

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The search for mechanisms of cognitive behavioral therapy for alcohol or other drug use disorders: A systematic review

Cited by 46 publications

References 47 publications

Transdiagnostic connectome-based prediction of craving

Transdiagnostic connectome-based prediction of craving

Mediators and Theories of Change in Psychotherapy for Young People With Personality Disorders: A Systematic Review Protocol

Mechanisms of behavior change in adolescent substance use treatment: A systematic review of treatment mediators and recommendations for advancing future research.

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