The Search for Biomarkers in Endometriosis: a Long and Windy Road

Králíčková, Milena; Větvička, Václav; Fiala, Luděk; Laganà, Antonio Simone; Garzon, Simone

doi:10.1007/s43032-021-00668-2

Cited by 15 publications

(12 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Retrograde menstruation with transplantation of shed endometrium is considered the primary etiopathogenic mechanism. However, its understanding is still incomplete [6][7][8]. Activity of macrophages causing proliferation of fibroblasts, formation of adhesive lesions and angiogenesis due to the inflammatory cascade has been reported [9].…”

Section: Introductionmentioning

confidence: 99%

“…Numerous biomarkers are potentially involved in the development of endometriosis including IL-31,IL-33, IL6,IL8, CD68, CD14 TGF-β1, COX-2, VEGF, ER-1β, aromatase, alarmins, CA-125,ABCG2, CD133 [10][11][12][13], TNF-α, MCP-1 [9] by causing an inflammatory response and some of them angiogenesis and growth of endometrial lesions potential. Their use as tool for diagnosis is limited by their lack of specificity and sensivity for endometriosis [14]. Currently the diagnosis is primally made through laparoscopy visualization [5].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Complementary pain management in endometriosis: a narrative review

Vera¹,

Castro²,

Zornosa³

et al. 2023

Ital J Gynaecol Obstet

View full text Add to dashboard Cite

Endometriosis is a gynecological disease characterized mainly by infertility, chronic pelvic as well by the disability that generates. In 2020, the WHO established that it affects approximately 10% of women and girls of reproductive age worldwide. Multiple surgical and pharmacological treatments have been recommended by different clinical practice guidelines for pain relief. Complementary therapies such as acupuncture, electrotherapy, massage, physical exercise, or diet have not been established as strong recommendation Nevertheless studies demostrated significant decrease in pain that support its use as an adjunct pain managment.Objective. To understand and expose the contribution of complementary therapies to pain relief in patients with endometriosis.Methodology. For the study, a search was carried out in: PubMed, Web of Science, Scopus, and Ovid databases with controlled descriptors in health, filtering 994 articles and including 12.Results. It was found that medical management for pain relief in patients with endometriosis is the basis of the treatment of this health condition. However, with complementary therapies a decrease in pain was demonstrated. This include: Transcutaneous electrical stimulation, neuromuscular pelvic floor manipulation, complementary alternative medical therapy, acupuncture technique on Ah Shi points, cognitive behavioral therapy, physical activity, diet and physioterapy. Information was found in 16 articles of experimental, observational studies and narrative reviews which support the use of complementary therapy as an adjunct in the management of pelvic pain.Conclusions. The use of complementary therapies are effective interventions for pain control in patients with endometriosis and should be recommended for pain improvements and quality of life.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Complementary pain management in endometriosis: a narrative review

Vera¹,

Castro²,

Zornosa³

et al. 2023

Ital J Gynaecol Obstet

View full text Add to dashboard Cite

show abstract

“…The prevalence of this disease ranges between six and ten percent [ 3 ], while the incidence is believed to be above 33% for patients with acute pelvic pain [ 4 ]. Nevertheless, it is difficult to precisely estimate the incidence and prevalence of superficial peritoneal endometriosis because of the absence of an accurate non-invasive biomarker [ 5 ]. The main symptoms for affected women include chronic pelvic pain, dysmenorrhea, infertility [ 6 ], and deep dyspareunia [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of lifestyle and diet on endometriosis: a fresh look to a busy corner

Habib¹,

Buzzaccarini²,

Centini³

et al. 2022

View full text Add to dashboard Cite

Endometriosis is a chronic inflammatory disorder with a prevalence of six to ten percent in women of childbearing age. As long as the aetiology of endometriosis is not fully understood and the disease has no definitive treatment, an examination of the environmental factors or interventions that could modify or cure endometriosis would greatly benefit women suffering from this chronic condition. This literature review utilized the electronic databases PubMed, EMBASE, and MEDLINE until February 2021. Studies indicate that fish oil may have a positive effect on reducing endometriosis-related pain due to the effects of pro-inflammatory prostaglandins derived from omega-3 fatty acids. The same effect was seen with the introduction of antioxidant vitamins C, D, and E. There is clinical viability of a low fermentable oligo-, di-, and mono-saccharides and polyols diet to successfully reduce the symptoms of patients who suffer from both endometriosis and irritable bowel syndrome. Despite the low level of evidence, there are frequent associations between endometriosis and gastrointestinal conditions in addition to the influence of various nutritional factors on the disease. The management of endometriosis requires a holistic approach focused on reducing overall inflammation, increasing detoxification, and attenuating troublesome symptoms. A dietician may provide great benefit in the management of these patients, especially at younger ages and in early stages. High-level evidence and well-designed randomized studies are lacking when it comes to studying the effect of lifestyle and dietary intake on endometriosis. Inarguably, further research with a more extensive focus is needed.

show abstract

“…from the data provided by the American Fertility Society. Psychometrics properties of endometriotic patients were associated with pain [12]- [14]. Endometriosis patients were identified with another important symptom known as Gastrointestinal symptom.…”

Section: Introductionmentioning

confidence: 99%

Symptoms based endometriosis prediction using machine learning

Visalaxi

Thalavaipillai

2021

Bulletin EEI

View full text Add to dashboard Cite

Endometriosis a painful disorder that stripes the uterus both inside and outside. Endometriosis can be diagnosed by the medical practitioners with the help of traditional scanning procedures. Laparoscopic surgery is the authentic method for identifying the advanced stages of endometriosis. The statistical approach is a state-of-art method for identifying the various stages of endometriosis using laparoscopic images. The paper focuses on a well-known statistical method known as chi-square and correlation coefficients are implemented for identifying the symptoms that are correlated with various stages of endometriosis. Chi-square analysis performs the association between symptoms and stages of endometriosis. With these analysis, an algorithm was proposed known as endometriosis prediction factor algorithm (EPF). The EPF algorithm predicts the presence of endometriosis if the derived value is greater than 1. From the chi-square analysis, it is identified that mild endometriosis is influenced 34% by menstrual flow, minimal endometriosis is influenced 40% by dysmenorrhea, where moderate endometriosis is influenced 31% by tenderness and deep infiltrating endometriosis is influenced 22% by adnexal mass.

show abstract

The Search for Biomarkers in Endometriosis: a Long and Windy Road

Cited by 15 publications

References 68 publications

Complementary pain management in endometriosis: a narrative review

Complementary pain management in endometriosis: a narrative review

Impact of lifestyle and diet on endometriosis: a fresh look to a busy corner

Symptoms based endometriosis prediction using machine learning

Contact Info

Product

Resources

About