Impact of lifestyle and diet on endometriosis: a fresh look to a busy corner

Abstract

Endometriosis is a chronic inflammatory disorder with a prevalence of six to ten percent in women of childbearing age. As long as the aetiology of endometriosis is not fully understood and the disease has no definitive treatment, an examination of the environmental factors or interventions that could modify or cure endometriosis would greatly benefit women suffering from this chronic condition. This literature review utilized the electronic databases PubMed, EMBASE, and MEDLINE until February 2021. Studies indicate that fish oil may have a positive effect on reducing endometriosis-related pain due to the effects of pro-inflammatory prostaglandins derived from omega-3 fatty acids. The same effect was seen with the introduction of antioxidant vitamins C, D, and E. There is clinical viability of a low fermentable oligo-, di-, and mono-saccharides and polyols diet to successfully reduce the symptoms of patients who suffer from both endometriosis and irritable bowel syndrome. Despite the low level of evidence, there are frequent associations between endometriosis and gastrointestinal conditions in addition to the influence of various nutritional factors on the disease. The management of endometriosis requires a holistic approach focused on reducing overall inflammation, increasing detoxification, and attenuating troublesome symptoms. A dietician may provide great benefit in the management of these patients, especially at younger ages and in early stages. High-level evidence and well-designed randomized studies are lacking when it comes to studying the effect of lifestyle and dietary intake on endometriosis. Inarguably, further research with a more extensive focus is needed.

Analysis of Adverse Events and Medical Errors in Long-Term Hormone Treatments for Endometriosis: A Study Based on the US Food and Drug Administration Event Reporting System

“…Besides, lifestyle and diet may affect symptoms, too. 25 The broad spectrum of PTs detected in this study may result from individual variation in ER-alpha and PR distributions. 26 It is reported that for patients with endometriosis who are intolerant of COC or norethisterone acetate’s side effects, shifting one to the other could improve their satisfaction.…”

Validation of a deep neural network-based algorithm supporting clinical management of adnexal mass

“…Information on imaging and physician impression of the masses was also not recorded frequently 10.3389/fmed.2023.1102437 enough to allow meaningful stratification on other diagnostic factors and this may hide interesting interactions in the data. Even though the study did not collect specific information of benign masses, the performance of OvaWatch might support the evaluation of adnexal mass suspicious as endometriosis cysts versus a mass arising from an endometrioid ovarian cancer or metastatic endometrial cancer to the ovary (32,(35)(36)(37)(38)(39) through the testing result of low probability of malignancy versus indeterminate.…”

Impact of Chronic Exposure to Endometriosis on Perinatal Outcomes: Establishment of a Mouse Model

“…This mouse model may also be useful in optimizing health care methods during the long preconception period. Although there are several epidemiological studies on the effects of lifestyle factors such as exercise and weight restriction [ 43 ], and diet factors such as high-fat diets and phytoestrogens on endometriosis, few animal studies have been reported [ 8 ]. Supplementation with inositol and melatonin, for example, has been reported to contribute to the normalization of glucose tolerance during pregnancy and is expected to positively impact fetal outcomes [ 44 , 45 ].…”