The sea lamprey tyrosine hydroxylase: cDNA cloning and in situ hybridization study in the brain

Barreiro‐Iglesias, Antón; Laramore, Cindy; Shifman, Michael I.; Anadón, Ramón; Selzer, Michael E.; Rodicio, Marı́a Celina

doi:10.1016/j.neuroscience.2010.04.025

Cited by 23 publications

(30 citation statements)

References 31 publications

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“…In addition, there is a good correspondence between the populations revealed by this anti‐DA antibody and those revealed by TH in situ hybridization (Barreiro‐Iglesias et al. 2010b).…”

Section: Methodsmentioning

confidence: 76%

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Restricted co‐localization of glutamate and dopamine in neurons of the adult sea lamprey brain

et al. 2017

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Co-localization of dopamine with other classical neurotransmitters in the same neuron is a common phenomenon in the brain of vertebrates. In mammals, some dopaminergic neurons of the ventral tegmental area and the hypothalamus have a glutamatergic co-phenotype. However, information on the presence of this type of dopaminergic neurons in other vertebrate groups is very scant. Here, we aimed to provide new insights on the evolution of this neuronal co-phenotype by studying the presence of a dual dopaminergic/glutamatergic neuron phenotype in the central nervous system of lampreys. Double immunofluorescence experiments for dopamine and glutamate in adult sea lampreys revealed co-localization of both neurotransmitters in some neurons of the preoptic nucleus, the nucleus of the postoptic commissure, the dorsal hypothalamus and in cerebrospinal fluid-contacting cells of the caudal rhombencephalon and rostral spinal cord. Moreover, co-localization of dopamine and glutamate was found in dopaminergic fibres in a few brain regions including the lateral pallium, striatum, and the preoptic and postoptic areas but not in the brainstem. Our results suggest that the presence of neurons with a dopaminergic/glutamatergic co-phenotype is a primitive character shared by jawless and jawed vertebrates. However, important differences in the distribution of these neurons and fibres were noted among the few vertebrates investigated to date. This study offers an anatomical basis for further work on the role of glutamate in dopaminergic neurons.

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“…In addition, there is a good correspondence between the populations revealed by this anti‐DA antibody and those revealed by TH in situ hybridization (Barreiro‐Iglesias et al. 2010b).…”

Section: Methodsmentioning

confidence: 76%

“…These neurons were observed in nuclei that contain both neurons expressing lamprey TH mRNA (Barreiro‐Iglesias et al. 2010b) and neurons expressing lamprey VGlut mRNA (Villar‐Cerviño et al. , ), as shown by in situ hybridization.…”

Section: Discussionmentioning

confidence: 96%

Restricted co‐localization of glutamate and dopamine in neurons of the adult sea lamprey brain

et al. 2017

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“…However, differences can be observed between lampreys and gnathostomes with regard to the expression of neuronal markers within this nucleus. In gnathostomes, some neurons of the nucleus of the solitary tract are catecholaminergic [Kivipelto et al, 1992;Cheng et al, 2006], whereas tyrosine hydroxylase immunoreactivity [Pierre-Simons et al, 2002;Pombal et al, 2006;Barreiro-Iglesias et al, 2010a] and tyrosine hydroxylase mRNA expression [Barreiro-Iglesias et al, 2010b] have not been observed in the nucleus of the solitary tract of lampreys.…”

Section: Central Gustatory Nucleimentioning

confidence: 97%

The Gustatory System of Lampreys

Barreiro‐Iglesias

Anadón

Rodicio³

2010

Brain Behav Evol

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“…The exact timing of the duplication cannot be ascertained until completion of the genome sequence in agnathostomes (jawless vertebrate; e.g., lamprey). A recent study showed that the lamprey Petromyzon marinus possess at least one TH gene (Barreiro-Iglesias et al, 2010). The phylogenetic analysis shows that the lamprey TH gene belongs to the clade of TH1 of jawed vertebrates rather than being an outgroup of TH1 and TH2.…”

Section: Molecular Components Defining the Phenotype Of Da Neurons Anmentioning

confidence: 99%

The Evolution of Dopamine Systems in Chordates

Yamamoto¹,

Vernier²

2011

Front. Neuroanat.

193

212

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Dopamine (DA) neurotransmission in the central nervous system (CNS) is found throughout chordates, and its emergence predates the divergence of chordates. Many of the molecular components of DA systems, such as biosynthetic enzymes, transporters, and receptors, are shared with those of other monoamine systems, suggesting the common origin of these systems. In the mammalian CNS, the DA neurotransmitter systems are diversified and serve for visual and olfactory perception, sensory–motor programming, motivation, memory, emotion, and endocrine regulations. Some of the functions are conserved among different vertebrate groups, while others are not, and this is reflected in the anatomical aspects of DA systems in the forebrain and midbrain. Recent findings concerning a second tyrosine hydroxylase gene (TH2) revealed new populations of DA-synthesizing cells, as evidenced in the periventricular hypothalamic zones of teleost fish. It is likely that the ancestor of vertebrates possessed TH2 DA-synthesizing cells, and the TH2 gene has been lost secondarily in placental mammals. All the vertebrates possess DA cells in the olfactory bulb, retina, and in the diencephalon. Midbrain DA cells are abundant in amniotes while absent in some groups, e.g., teleosts. Studies of protochordate DA cells suggest that the diencephalic DA cells were present before the divergence of the chordate lineage. In contrast, the midbrain cell populations have probably emerged in the vertebrate lineage following the development of the midbrain–hindbrain boundary. The functional flexibility of the DA systems, and the evolvability provided by duplication of the corresponding genes permitted a large diversification of these systems. These features were instrumental in the adaptation of brain functions to the very variable way of life of vertebrates.

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The sea lamprey tyrosine hydroxylase: cDNA cloning and in situ hybridization study in the brain

Cited by 23 publications

References 31 publications

Restricted co‐localization of glutamate and dopamine in neurons of the adult sea lamprey brain

Restricted co‐localization of glutamate and dopamine in neurons of the adult sea lamprey brain

The Gustatory System of Lampreys

The Evolution of Dopamine Systems in Chordates

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