The Screening of Permeation Enhancers for Trans-Nail Delivery of Terbinafine Hydrochloride

Kushwaha, Abhishek

doi:10.4172/0975-0851.1000381

Cited by 5 publications

(1 citation statement)

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“…However, in systemic treatments several aspects concerning therapeutical safety, such as side effects, drug interactions and risks associated with hepatic injury may limit their desirability, especially in the elderly population that is the most affected by comorbidities, being an obstacle for managing these diseases [3,[10][11][12]. Furthermore, systemic treatments for onychomycosis have a significant limitation related to poor blood circulation in the nail apparatus, leading to poor drug transport [49]. In this sense, oral therapy has found a restricted success rate due to drug interactions, side effects, contraindications, toxicity and high treatment cost [9].…”

Section: Limitations On Nail Treatmentsmentioning

confidence: 99%

Recent Patents on Permeation Enhancers for Drug Delivery Through Nails

Kreutz

Matos

Koester

2020

DDF

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: The human nail is a unique barrier with a keratinized constitution that favors protection and fine touch. However, many disorders can affect the nail, among them, are the onychomycosis and psoriasis. Systemic oral therapy has been applied to treat these diseases, even presenting disadvantages, including side effects, drug interactions, contraindications, toxicity, high cost and low patient compliance. A great option to succeed in dealing with the problems associated with oral therapy is the topical administration of drugs. However, nail composition, low diffusion through ungual route and reduced tissue bioavailability for topical treatments are limiting factors. These drawbacks can be overcome by promoting penetration through the nails by employing penetration enhancers. The review focuses on patents that highlight permeation enhancers applied to nail drug delivery for the treatment of onychomycosis and psoriasis. Literature and patent searches were conduced regarding the topic of interest. The substantial literature and patent search revealed that permeation enhancers, especially chemicals, are great strategies for promoting the ungual delivery of drugs. Nail topical therapy containing permeation enhancers is an attractive option for delivering localized treatments.

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