Beneficial effects of topical 6-gingerol loaded nanoemulsion gel for wound and inflammation management with their comparative dermatokinetic

Ahmad, Niyaz; Khalid, Mohammed Saifuddin; Khan, Mohd Faiyaz; Ullah, Zabih

doi:10.1016/j.jddst.2022.104094

Cited by 10 publications

(2 citation statements)

References 68 publications

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“…Several contributions proposed the inclusion of PEG 400 in some model nanocolloidal systems for drug solubilization. PEG 400 1–2.5% was included in the form of gel-based nanoemulsions containing 6-gingerol 10%, oleic acid 1–5%, Tween 20 4–10%, and water 82.5–94%, for wound treatment [ 76 ]. PEG 400 6.5–10% was selected in formulations designed for intranasal delivery to increase the rate of survival in glioblastoma treatment [ 77 ], while concentrations of 15–21% were selected for designing microemulsions for the oral delivery of carvedilol as suitable solubilizer that acts synergistically with peppermint oil 10% and Tween 80 15–21% [ 78 ].…”

Section: Resultsmentioning

confidence: 99%

Development and Characterization of New Miconazole-Based Microemulsions for Buccal Delivery by Implementing a Full Factorial Design Modeling

Talianu,

Dinu-Pîrvu,

Ghica

et al. 2024

Pharmaceutics

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This research aimed to develop miconazole-based microemulsions using oleic acid as a natural lipophilic phase and a stabilizer mixture comprising Tween 20 and PEG 400 to solubilize miconazole as an antifungal agent known for its activity in oral candidiasis and to improve its bioavailability. The formulation and preparation process was combined with a mathematical approach using a 23-full factorial plan. Fluid and gel-like microemulsions were obtained and analyzed considering pH, conductivity, and refractive index, followed by extensive analyses focused on droplet size, zeta potential, rheological behavior, and goniometry. In vitro release tests were performed to assess their biopharmaceutical characteristics. Independent variables coded X1-Oleic acid (%, w/w), X2-Tween 20 (%, w/w), and X3-PEG 400 (%, w/w) were analyzed in relationship with three main outputs like mean droplet size, work of adhesion, and diffusion coefficient by combining statistical tools with response surface methodology. The microemulsion containing miconazole base–2%, oleic acid–5%, Tween 20–40%, PEG 400–20%, and water–33% exhibited a mean droplet size of 119.6 nm, a work of adhesion of 71.98 mN/m, a diffusion coefficient of 2.11·10−5 cm2/s, and together with remarked attributes of two gel-like systems formulated with higher oil concentrations, modeled the final optimization step of microemulsions as potential systems for buccal delivery.

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Section: Resultsmentioning

confidence: 99%

Development and Characterization of New Miconazole-Based Microemulsions for Buccal Delivery by Implementing a Full Factorial Design Modeling

Talianu,

Dinu-Pîrvu,

Ghica

et al. 2024

Pharmaceutics

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“…Several strategies have been used to increase the bioavailability of these compounds by various researchers [ 24 , 25 ]. For skin delivery of bioactive compounds, lipid-based nanocarriers such as liposomes [ 26 ], nanoemulsions [ 27 ], microemulsions [ 28 ], ethosomes [ 29 ], and solid lipid nanoparticles [ 30 ] have been frequently reported. The delivery of active chemical compounds through the barriers of the skin, namely the stratum corneum, is the most difficult aspect of developing drug delivery [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

QbD-Optimized, Phospholipid-Based Elastic Nanovesicles for the Effective Delivery of 6-Gingerol: A Promising Topical Option for Pain-Related Disorders

Ghazwani

Alqarni

Hani

et al. 2023

IJMS

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In this study, elastic nanovesicles, constructed of phospholipids optimized by Quality by Design (QbD), release 6-gingerol (6-G), a natural chemical that may alleviate osteoporosis and musculoskeletal-related pain. A 6-gingerol-loaded transfersome (6-GTF) formulation was developed using a thin film and sonication approach. 6-GTFs were optimized using BBD. Vesicle size, PDI, zeta potential, TEM, in vitro drug release, and antioxidant activity were evaluated for the 6-GTF formulation. The optimized 6-GTF formulation had a 160.42 nm vesicle size, a 0.259 PDI, and a −32.12 mV zeta potential. TEM showed sphericity. The 6-GTF formulation’s in vitro drug release was 69.21%, compared to 47.71% for the pure drug suspension. The Higuchi model best described 6-G release from transfersomes, while the Korsmeyer–Peppas model supported non-Fickian diffusion. 6-GTF had more antioxidant activity than the pure 6-G suspension. The optimized transfersome formulation was converted into a gel to improve skin retention and efficacy. The optimized gel had a spreadability of 13.46 ± 4.42 g·cm/s and an extrudability of 15.19 ± 2.01 g/cm2. The suspension gel had a 1.5 μg/cm2/h ex vivo skin penetration flux, while the 6-GTF gel had 2.71 μg/cm2/h. Rhodamine B-loaded TF gel reached deeper skin layers (25 μm) compared to the control solution in the CLSM study. The gel formulation’s pH, drug concentration, and texture were assessed. This study developed QbD-optimized 6-gingerol-loaded transfersomes. 6-GTF gel improved skin absorption, drug release, and antioxidant activity. These results show that the 6-GTF gel formulation has the ability to treat pain-related illnesses effectively. Hence, this study offers a possible topical treatment for conditions connected to pain.

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Plant-Based Biomaterials in Tissue Engineering and Drug Delivery Systems

Izadyari Aghmiuni,

Ghadi,

Azmoun

2023

Engineering Materials

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Beneficial effects of topical 6-gingerol loaded nanoemulsion gel for wound and inflammation management with their comparative dermatokinetic

Cited by 10 publications

References 68 publications

Development and Characterization of New Miconazole-Based Microemulsions for Buccal Delivery by Implementing a Full Factorial Design Modeling

Development and Characterization of New Miconazole-Based Microemulsions for Buccal Delivery by Implementing a Full Factorial Design Modeling

QbD-Optimized, Phospholipid-Based Elastic Nanovesicles for the Effective Delivery of 6-Gingerol: A Promising Topical Option for Pain-Related Disorders

Plant-Based Biomaterials in Tissue Engineering and Drug Delivery Systems

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