The Science of Vascular Contributions to Cognitive Impairment and Dementia (VCID): A Framework for Advancing Research Priorities in the Cerebrovascular Biology of Cognitive Decline

Corriveau, Roderick A.; Bosetti, Francesca; Emr, Marian; Gladman, Jordan T.; Koenig, James I.; Moy, Claudia S.; Pahigiannis, Katherine; Waddy, Salina P.; Koroshetz, Walter J.

doi:10.1007/s10571-016-0334-7

Cited by 175 publications

(168 citation statements)

References 69 publications

(83 reference statements)

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“…This has further led to the usage of the general terms, for example, VCI or VCID, in order to include all cognitive impairments caused by cerebrovascular abnormalities, which could be quite confusing. Essentially, VCI or VCID is used to include a diverse heterogeneous group of cognitive syndromes with vascular origins regardless of the cause of pathogenesis, ranging from mild cognitive impairment to full-blown dementia, and VaD is the most severe stage [3, 8, 18]. The heterogeneity and complexity of VCI however make it difficult for appropriate clinical characterization.…”

Section: Definitions Of Vascular Dementia (Vad) Vascular Cognitivmentioning

confidence: 99%

Vascular Contributions to Cognitive Impairment and Treatments with Traditional Chinese Medicine

Zhou

Cui

Tseng

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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The prevalence of cognitive impairment and dementia caused by cerebrovascular disease is likely to increase with the global aging population. Vascular contributions to cognitive impairment and dementia (VCID) is a wide spectrum term used to include a diverse heterogeneous group of cognitive syndromes with vascular factors regardless of the cause of pathogenesis. VCID ranges from mild cognitive impairment to full-blown dementia with vascular dementia (VaD) as the most severe stage. It is further complexed by the coexistence of other forms of dementia such as Alzheimer's disease (AD). Recent researches in the functions of the neurovascular unit (NVU) suggest that dysfunction of the NVU might be the cause of primary vascular events in the brain that leads to further neurodegeneration. In this review, we have briefly summarized various forms of VCID. There is currently no standard therapy for VCID or dementia. Given the fact that Traditional Chinese Medicine (TCM) has gained popularity worldwide, we also reviewed recent scientific and clinical findings on various antidementia TCM for the treatment of VCID, including Salvia miltiorrhiza, Huperzia serrata, Ligusticum chuanxiong, Ginkgo biloba, Panax ginseng, and also TCM formula Sailuotong capsule (SLT) and Fufangdanshen tablets (FFDS).

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Section: Definitions Of Vascular Dementia (Vad) Vascular Cognitivmentioning

confidence: 99%

Vascular Contributions to Cognitive Impairment and Treatments with Traditional Chinese Medicine

Zhou

Cui

Tseng

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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“…Vascular cognitive impairment dementia (VCID) is the term suggested for all forms of dementia related to vascular diseas (Corriveau et al, 2016). The term includes multiple forms of stroke, which can be separated into large vessel and small vessel disease (SVD).…”

Section: Introductionmentioning

confidence: 99%

Rodent Models of Vascular Cognitive Impairment

Yang

Kimura-Ohba

Thompson

et al. 2016

Transl. Stroke Res.

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Vascular cognitive impairment dementia (VCID), which is an increasingly important cause of dementia in the elderly, lacks effective treatments. Many different types of vascular disease are included under the diagnosis of VCID, including large vessel disease with multiple strokes, and small vessel disease with lacunar infarcts and white matter disease. Animal models have been developed to study the multiple forms of VCID. Because of its progressive course, small vessel disease (SVD) is thought to be the optimal form of VCID for treatment. One theory is that the pathophysiology involves hypoxic hypoperfusion resulting in injury to the white matter and neuronal death. Bilateral occlusion of the common carotid arteries (BCAO) in a normotensive rat, which reduces cerebral blood flow, induces hypoxia with white matter damage; this model has been used to test drugs to block the injury. Another model is the spontaneously hypertensive/stroke prone rat (SHR/SP). Hypertension leads to small vessel disease resulting in progressive damage to the white matter, cortex and hippocampus. Bilateral carotid artery stenosis (BCAS) with coils or ameroid constrictors produces a slower development of changes than BCAO, avoiding the acute ischemia. A few studies have been done with the two-clip, two-vessel occlusion renal model for induction of hypertension. There are benefits and drawbacks to each of these models with the model selected depending on the type of vascular damage that is to be studied. This review describes the most commonly used models, and the drugs that have been used to reduce the damage.

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“…Vascular contributions to cognitive impairment and dementia (VCID) in aging have garnered much interest in the past decade (Corriveau et al 2016;Csiszar et al 2017;Gorelick et al 2011;Snyder et al 2015;Toth et al 2017;Tucsek et al 2017). There are numerous agerelated vascular pathologies underlying VCID.…”

Section: Introductionmentioning

confidence: 99%

Pharmacologically induced impairment of neurovascular coupling responses alters gait coordination in mice

et al. 2017

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There is correlative evidence that impaired cerebral blood flow (CBF) regulation, in addition to promoting cognitive impairment, is also associated with alterations in gait and development of falls in elderly people. CBF is adjusted to neuronal activity via neurovascular coupling (NVC) and this mechanism becomes progressively impaired with age. To establish a direct cause-andeffect relationship between impaired NVC and gait abnormalities, we induced neurovascular uncoupling pharmacologically in young C57BL/6 mice by inhibiting the synthesis of vasodilator mediators involved in NVC. Treatment of mice with the epoxygenase inhibitor MSPPOH, the NO synthase inhibitor L-NAME, and the COX inhibitor indomethacin significantly decreased NVC mimicking the aging phenotype. Pharmacologically induced neurovascular uncoupling significantly decreased the dynamic gait parameter duty cycle, altered footfall patterns, and significantly increased phase dispersion, indicating impaired interlimb coordination. Impaired NVC also tended to increase gait variability. Thus, selective experimental disruption of NVC causes subclinical gait abnormalities, supporting the importance of CBF in both cognitive function and gait regulation.

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The Science of Vascular Contributions to Cognitive Impairment and Dementia (VCID): A Framework for Advancing Research Priorities in the Cerebrovascular Biology of Cognitive Decline

Cited by 175 publications

References 69 publications

Vascular Contributions to Cognitive Impairment and Treatments with Traditional Chinese Medicine

Vascular Contributions to Cognitive Impairment and Treatments with Traditional Chinese Medicine

Rodent Models of Vascular Cognitive Impairment

Pharmacologically induced impairment of neurovascular coupling responses alters gait coordination in mice

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