“…Additionally, CCL2 enhances IL-4 secretion by T cells and elicits Th2 polarising effects, and miR-142 has an important role in DC priming of Th2 responses (Gu et al, 2000;Belz, 2013), both up-regulated in MNC-treated mice. Alternative therapeutic strategies that exploit counterregulatory pathways, such as parasites used to skew mucosal immune responses and favour barrier protection, involve alternatively activated macrophages, eosinophils, Th2 cells and Tregs (Smith et al, 2007;Hunter et al, 2010;Gause et al, 2013;Driss et al, 2016). These cells play a key role in the resolution of intestinal inflammation, for example, by producing anti-inflammatory lipid mediators that activate this process (Sherman and Kalman, 2004;Wang and Colgan, 2017).…”