Immunomodulatory tetracyclines shape the intestinal inflammatory response inducing mucosal healing and resolution

Garrido-Mesa, José; Rodríguez-Nogales, A; Algieri, Francesca; Vezza, Teresa; Hidalgo-García, Laura; Garrido-Barros, María; Utrilla, M. Pilar; García, Féderico; Chueca, Natalia; Rodríguez-Cabezas, Maria Elena; Garrido-Mesa, Natividad; Gálvez, Júlio

doi:10.1111/bph.14494

Cited by 39 publications

(35 citation statements)

References 77 publications

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“…Indeed, it was demonstrated with in vitro and ex vivo studies how a short-term treatment with broad-spectrum antibiotics deeply affected both cellular and humoral immune response [ 79 , 80 , 81 ]. Some antibiotics have been reported to display immunomodulatory effect in addition to their antimicrobial activity [ 82 , 83 , 84 ]. Konstantinidis et al demonstrated that macrolides such as clarithromycin can induce Neutrophils Extracellular Trap (NET) generation both in vitro and in vivo.…”

Section: Antibiotic-associated Shifts In the Gut Microbiotamentioning

confidence: 99%

Effects of Antibiotics upon the Gut Microbiome: A Review of the Literature

et al. 2020

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The human gastrointestinal tract carries a large number of microorganisms associated with complex metabolic processes and interactions. Although antibiotic treatment is crucial for combating infections, its negative effects on the intestinal microbiota and host immunity have been shown to be of the utmost importance. Multiple studies have recognized the adverse consequences of antibiotic use upon the gut microbiome in adults and neonates, causing dysbiosis of the microbiota. Repeated antibiotic treatments in clinical care or low-dosage intake from food could be contributing factors in this issue. Researchers in both human and animal studies have strived to explain this multifaceted relationship. The present review intends to elucidate the axis of the gastrointestinal microbiota and antibiotics resistance and to highlight the main aspects of the issue.

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Section: Antibiotic-associated Shifts In the Gut Microbiotamentioning

confidence: 99%

Effects of Antibiotics upon the Gut Microbiome: A Review of the Literature

et al. 2020

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“…Previous studies have shown that microRNAs are considered as significant regulators in the maintenance of epithelial barrier function [ 131 ], cell apoptosis [ 132 ], cell proliferation and differentiation [ 133 , 134 ], and immune functions [ 135 , 136 ]. It was found that microRNAs can trigger apoptosis and differentiation of intestinal epithelial cells and immune cells, which modulate the overall intestinal immunity for maintaining a delicately balanced status of intestinal environment [ 137 , 138 , 139 ]. In addition, it has also been reported that the microRNAs secreted by host intestinal cells can regulate the growth of microbes and the abundance of intestinal microflora via DNA exchanging, impact the target bacteria at the DNA level.…”

Section: Microrna In Modulating Gut Intestinal Microbiotamentioning

confidence: 99%

MicroRNAs Regulate Intestinal Immunity and Gut Microbiota for Gastrointestinal Health: A Comprehensive Review

Zhang

Chen

et al. 2020

Genes

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MicroRNAs are small non-coding RNAs regulating gene expression at the post-transcriptional level. The regulation of microRNA expression in the gut intestine is gradually recognized as one of the crucial contributors of intestinal homeostasis and overall health. Recent studies indicated that both the microRNAs endogenous in the gut intestine and exogenous from diets could play influential roles in modulating microbial colonization and intestinal immunity. In this review, we discuss the biological functions of microRNAs in regulating intestinal homeostasis by modulating intestinal immune responses and gut microbiota. We particularly focus on addressing the microRNA-dependent communication and interactions among microRNA, gut microbiota, and intestinal immune system. Besides, we also summarize the roles of diet-derived microRNAs in host-microbiome homeostasis and their benefits on intestinal health. A better understanding of the relationships among intestinal disorders, microRNAs, and other factors influencing intestinal health can facilitate the application of microRNA-based therapeutics for gastrointestinal diseases.

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“…For example, macrolide antibiotics are used in the treatment of several chronic inflammatory diseases, such as chronic obstructive pulmonary disease (COPD) (Uzun et al, 2014), asthma (Gibson et al, 2017), and non-cystic fibrosis bronchiectasis (Li et al, 2019), due to their immunomodulatory properties. Minocycline and doxycycline have shown beneficial effects on experimental colitis (Garrido-Mesa et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Linezolid and Its Immunomodulatory Effect: In Vitro and In Vivo Evidence

et al. 2019

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Recent studies have explored the effects of some antibacterial agents on various aspects of the immune response to infection in addition to their bactericidal effects. As a synthetic oxazolidinone class of antibacterial agent, linezolid (LZD) exhibits activity against a broad range of Gram-positive bacteria. In the present review, we summarized the effects of LZD on the immune response and new approaches that can exploit such interactions for the treatment of bacterial infections. In vitro and pre-clinical evidence demonstrate that LZD suppresses the phagocytic ability, cytokine synthesis, and secretion of immune cells as well as the expressions of immune-related genes at the mRNA level under the stimulation of endotoxin or pathogens. Immunomodulatory effects of LZD can not only reduce the inflammatory damage induced by exaggerated or prolonged release of pro-inflammatory cytokines during infections but can also be applied to alleviate the symptoms of non-infectious inflammatory conditions. Further research is necessary to explore the molecular mechanisms involved and confirm these findings in clinical practice.

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Immunomodulatory tetracyclines shape the intestinal inflammatory response inducing mucosal healing and resolution

Abstract: Immunomodulatory tetracyclines potentiate protective immune pathways leading to mucosal healing and resolution, representing a promising drug reposition strategy for the treatment of intestinal inflammation.

Cited by 39 publications

References 77 publications

Effects of Antibiotics upon the Gut Microbiome: A Review of the Literature

Effects of Antibiotics upon the Gut Microbiome: A Review of the Literature

MicroRNAs Regulate Intestinal Immunity and Gut Microbiota for Gastrointestinal Health: A Comprehensive Review

Linezolid and Its Immunomodulatory Effect: In Vitro and In Vivo Evidence

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