“…However, most of the studies on this topic have employed pooled salivas or individual salivas from a limited number of subjects (Buettner, 2002a(Buettner, , 2002bGenovese et al, 2009;Munoz-Gonzalez et al, 2018b;Munoz-Gonzalez et al, 2014;Pages-Helary et al, 2014) that do not represent properly the well-known interindividual variability of human saliva composition in healthy individuals (Leake, Pagni, Falquet, Taroni, & Greub, 2016;Neyraud, Palicki, Schwartz, Nicklaus, & Feron, 2012). Additionally, different pathologies or functional states can provoke biochemical and microbiological changes in salivary parameters raising the differences in specific populations (Castagnola, Cabras, Vitali, Sanna, & Messana, 2011;Schipper, Silletti, & Vinyerhoeds, 2007).…”