Circadian oscillations of microbial and functional composition in the human salivary microbiome

Takayasu, Lena; Suda, Wataru; Takanashi, Kageyasu; Iioka, Erica; Kurokawa, Rina; Shindo, Chie; Hattori, Yasue; Yamashita, Naoko; Nishijima, Suguru; Oshima, Koichiro; Hattori, Masahira

doi:10.1093/dnares/dsx001

Cited by 79 publications

(78 citation statements)

References 38 publications

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“…In addition, food timing affected salivary microbiota diurnal rhythms in individual bacterial taxa. Recently, salivary microbiota in the human oral cavity have been shown to exhibit global daily rhythms in both the Firmicutes and Bacteroidetes phyla (59). Consistently, our salivary microbiota results showed similar trends in daily rhythms in the relative abundance of these microbial groups.…”

Section: Discussionmentioning

confidence: 99%

Timing of food intake impacts daily rhythms of human salivary microbiota: a randomized, crossover study

Collado¹,

et al. 2018

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The composition of the diet (what we eat) has been widely related to the microbiota profile. However, whether the timing of food consumption (when we eat) influences microbiota in humans is unknown. A randomized, crossover study was performed in 10 healthy normal-weight young women to test the effect of the timing of food intake on the human microbiota in the saliva and fecal samples. More specifically, to determine whether eating late alters daily rhythms of human salivary microbiota, we interrogated salivary microbiota in samples obtained at 4 specific time points over 24 h, to achieve a better understanding of the relationship between food timing and metabolic alterations in humans. Results revealed significant diurnal rhythms in salivary diversity and bacterial relative abundance (i.e., TM7 and Fusobacteria) across both early and late eating conditions. More importantly, meal timing affected diurnal rhythms in diversity of salivary microbiota toward an inverted rhythm between the eating conditions, and eating late increased the number of putative proinflammatory taxa, showing a diurnal rhythm in the saliva. In a randomized, crossover study, we showed for the first time the impact of the timing of food intake on human salivary microbiota. Eating the main meal late inverts the daily rhythm of salivary microbiota diversity which may have a deleterious effect on the metabolism of the host.-Collado, M. C., Engen, P. A., Bandín, C., Cabrera-Rubio, R., Voigt, R. M., Green, S. J., Naqib, A., Keshavarzian, A., Scheer, F. A. J. L., Garaulet, M. Timing of food intake impacts daily rhythms of human salivary microbiota: a randomized, crossover study. FASEB J. 32, 2060FASEB J. 32, -2072FASEB J. 32, (2018. www.fasebj.orgRecent studies suggest that not only what we eat, but also when we eat may have a significant role in obesity treatment and metabolic alterations (1-6). Unusual feeding times can induce a disruption of the circadian system, which may lead to metabolic dysfunction (7-11). For example, in a longitudinal study of an overweight and obese Mediterranean population, our group demonstrated that those who ate lunch later in the day (main meal for this population) lost significantly less weight than those who ate lunch early, although early eaters (EEs) and late eaters (LEs) showed similar food intake, physical activity, sleep duration, and appetite-related hormone levels (2). Moreover, LEs had significantly higher insulin resistance. In the same line, a randomized, crossover study demonstrated that meal timing affects glucose tolerance, suggesting that eating late increases metabolic risk, even in healthy women (7).The importance of caloric distribution across the day in weight loss effectiveness was supported by a 12-wk experimental study showing that participants assigned to high caloric intake during breakfast lost significantly more weight than those assigned to high caloric intake ABBREVIATIONS: ANOSIM, analysis of similarity; BMI, body mass index; EE, early eater; F/B, Firmicutes/Bacteroidetes; FD...

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Section: Discussionmentioning

confidence: 99%

Timing of food intake impacts daily rhythms of human salivary microbiota: a randomized, crossover study

Collado¹,

et al. 2018

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“…The SM has been demonstrated to be individualized [17,18] and temporarily stable [19,20] in orally healthy individuals. On the other hand, circadian oscillations of SM have also been documented [21].…”

Section: The Salivary Microbiota In Oral Healthmentioning

confidence: 99%

The salivary microbiota in health and disease

Belstrøm

2020

Journal of Oral Microbiology

141

112

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The salivary microbiota (SM), comprising bacteria shed from oral surfaces, has been shown to be individualized, temporally stable and influenced by diet and lifestyle. SM reflects local bacterial alterations of the supragingival and subgingival microbiota, and periodontitis and dental-caries associated characteristics of SM have been reported. Also, data suggest an impact of systemic diseases on SM as demonstrated in patients with a wide variety of systemic diseases including diabetes, cancer, HIV and rheumatoid arthritis. The presence of systemic diseases seems to influence salivary levels of specific bacterial species, as well as αand β-diversity of SM. The composition of SM might thereby potentially mirror oral and general health status. The contentious development of advanced molecular techniques such as metagenomics, metatranscriptomics and metabolomics has enabled the possibility to address bacterial functions rather than presence in microbial samples. However, at present only a few studies have employed such techniques on SM to reveal functional and metabolic characteristics in oral health and disease. Future studies are therefore warranted to illuminate the possible impact of metabolic functions of SM on oral and general health status. Ultimately, such an approach has the possibility to reveal novel and personalized therapeutic avenues in oral and general medicine.

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“…Given the difficulties to retrieve stool samples around the course of a day, some clinical studies focused on the more accessible human salivary microbiome. These studies showed that abundance and transcriptional activity of microbes in human saliva appear rhythmic aside from a report that fails to detect these diurnal variations . Similar to the observations in mouse gut microbiota, an altered feeding schedule in humans impacts the diurnal fluctuation in microbiota abundance .…”

Section: Diurnal Oscillations In Microbiotamentioning

confidence: 69%

At the Intersection of Microbiota and Circadian Clock: Are Sexual Dimorphism and Growth Hormones the Missing Link to Pathology?

2019

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Reciprocal interactions between the host circadian clock and the microbiota are evidenced by recent literature. Interestingly, dysregulation of either the circadian clock or microbiota is associated with common human pathologies such as obesity, type 2 diabetes, or neurological disorders. However, it is unclear to what extent a perturbation of pathways regulated by both the circadian clock and microbiota is involved in the development of these disorders. It is speculated that these perturbations are associated with impaired growth hormone (GH) secretion and sexual development. The GH axis is a broadly neglected pathway and could be the main converging point for the interaction of both circadian clock and microbiota. Here, the links between the circadian clock and microbiota are reviewed. Finally, the effects of chronodisruption and dysbiosis on physiology and pathology are discussed and it is speculated whether a common deregulation of the GH pathway could mediates those effects.

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Circadian oscillations of microbial and functional composition in the human salivary microbiome

Cited by 79 publications

References 38 publications

Timing of food intake impacts daily rhythms of human salivary microbiota: a randomized, crossover study

Timing of food intake impacts daily rhythms of human salivary microbiota: a randomized, crossover study

The salivary microbiota in health and disease

At the Intersection of Microbiota and Circadian Clock: Are Sexual Dimorphism and Growth Hormones the Missing Link to Pathology?

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