The salient role of microRNAs in atherogenesis

Donaldson, Callum J.; Lao, Ka Hou; Zeng, Lingfang

doi:10.1016/j.yjmcc.2018.08.004

Cited by 27 publications

(39 citation statements)

References 175 publications

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“…High intensity interval exercise elicits greater shear rate along the vessel wall as compared with a matched bout of moderate continuous exercise (Atkinson, Carter, et al, 2015; Johnson & Wallace, 2012; McManus, Sletten, & Green, 2019). The pattern and magnitude of shear stress is important in regulating endothelial cell expression of miRs (Donaldson et al., 2018; Lee & Chiu, 2019) and it was recently shown that increased shear stress elicits the release of miR from cultured endothelial cells that are also increased in circulation in response to acute exercise ( Schmitz et al., 2019). Other factors that could contribute to changes in arterial stiffness include acute elevations in inflammation and ROS, stimuli known to increase with exercise in an intensity‐dependent manner (Allen, Sun, & Woods, 2015; Johnson et al., 2012; McClean et al., 2015; Vlachopoulos et al., 2005; Vucinovic et al., 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Other factors that could contribute to changes in arterial stiffness include acute elevations in inflammation and ROS, stimuli known to increase with exercise in an intensity‐dependent manner (Allen, Sun, & Woods, 2015; Johnson et al., 2012; McClean et al., 2015; Vlachopoulos et al., 2005; Vucinovic et al., 2015). Both of these factors are also known regulators of miR expression and release by vascular cells (Alexy et al., 2014; Donaldson et al., 2018; Lee & Chiu, 2019), suggesting ci‐miRs may contribute to exercise‐induced changes in arterial stiffness.…”

Section: Discussionmentioning

confidence: 99%

“…MicroRNAs (miRs) are post‐transcriptional regulators of gene expression that have been implicated as a novel class of molecules important in maintaining arterial health and mediating cardiovascular responses to exercise (Bartel, (2018); Donaldson, Lao, & Zeng, 2018; Fernández‐Hernando & Suárez, 2018; Lee & Chiu, 2019; Nanoudis, Pikilidou, Yavropoulou, & Zebekakis, 2017; Sapp, Shill, Roth, & Hagberg, 2017; Sapp & Hagberg, 2019). Circulating miRs (ci‐miRs) released from cells into the bloodstream are proposed as novel biomarkers and mediators of cardiovascular exercise responses, as well as CVD (Johnson, 2019; Njock & Fish, 2017; Sapp & Hagberg, 2019; Sapp et al., 2017,).…”

Section: Introductionmentioning

confidence: 99%

“…The levels of specific ci‐miRs correlate with arterial stiffness in humans (Deng et al., 2017; Parthenakis et al., 2017; Van Craenenbroeck et al., 2016). Additionally, in vitro and animal experiments have shown that changes in specific vascular stimuli such as shear stress and inflammation affect the expression and release of microRNAs from vascular cells, suggesting these molecules may play roles in exercise intensity‐dependent changes in arterial stiffness (Alexy, Rooney, Weber, Gray, & Searles, 2014; Donaldson et al., 2018; Hale et al., 1843; Lee & Chiu, 2019; Schmitz et al., 2019; Zhou et al., 2013).…”

Section: Introductionmentioning

confidence: 99%

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Changes in circulating microRNA and arterial stiffness following high‐intensity interval and moderate intensity continuous exercise

et al. 2020

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High-intensity interval (HII) exercise elicits distinct vascular responses compared to a matched dose of moderate intensity continuous (MOD) exercise. However, the acute effects of HII compared to MOD exercise on arterial stiffness are incompletely understood. Circulating microRNAs (ci-miRs) may contribute to the vascular effects of exercise. We sought to determine exercise intensity-dependent changes in ci-miR potentially underlying changes in arterial stiffness. Ten young, healthy men underwent well-matched, 30-min HII and MOD exercise bouts. RT-qPCR was used to determine the levels of seven vascular-related ci-miRs in serum obtained immediately before and after exercise. Arterial stiffness measures including carotid to femoral pulse wave velocity (cf-PWV), carotid arterial compliance and β-stiffness, and augmentation index (AIx and AIx75) were taken before, 10min after and 60min after exercise. Ci-miR-21-5p, 126-3p, 126-5p, 150-5p, 155-5p, and 181b-5p increased after HII exercise (p < .05), while ci-miR-150-5p and 221-3p increased after MOD exercise (p = .03 and 0.056). One hour after HII exercise, cf-PWV trended toward being lower compared to baseline (p = .056) and was significantly lower compared to 60min after MOD exercise (p = .04). Carotid arterial compliance was increased 60min after HII exercise (p = .049) and was greater than 60min after MOD exercise (p = .02). AIx75 increased 10 min after both HII and MOD exercise (p < .05).There were significant correlations between some of the exercise-induced changes in individual ci-miRs and changes in cf-PWV and AIx/AIx75. These results support the hypotheses that arterial stiffness and ci-miRs are altered in an exercise intensitydependent manner, and ci-miRs may contribute to changes in arterial stiffness.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Changes in circulating microRNA and arterial stiffness following high‐intensity interval and moderate intensity continuous exercise

et al. 2020

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“…miRNAs are a class of single-stranded, small (about 22 nucleotides long) and generally non-coding RNAs, which have emerged as critical regulators of gene expression via post-transcriptional degradation or translational repression. [37][38][39] Each mRNA molecule may be regulated by multiple miRNAs, and a single miRNA may influence the expression of a wild range of genes in a cell. 40 Some miRNAs are expressed ubiquitously, and some miRNAs are expressed in a tissue-specific and/or stage-specific manner.…”

Section: Mirnasmentioning

confidence: 99%

The role of microvesicles containing microRNAs in vascular endothelial dysfunction

Shu

Tan

Miao

et al. 2019

J Cellular Molecular Medi

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Many studies have shown that endothelial dysfunction is associated with a variety of cardiovascular diseases. The endothelium is one of the primary targets of circulating microvesicles. Besides, microRNAs emerge as important regulators of endothelial cell function. As a delivery system of microRNAs, microvesicles play an active and important role in regulating vascular endothelial function. In recent years, some studies have shown that microvesicles containing microRNAs regulate the pathophysiological changes in vascular endothelium, such as cell apoptosis, proliferation, migration and inflammation. These studies have provided some clues for the possible roles of microvesicles and microRNAs in vascular endothelial dysfunction‐associated diseases, and opened the door towards discovering potential novel therapeutic targets. In this review, we provide an overview of the main characteristics of microvesicles and microRNAs, summarizing their potential role and mechanism in endothelial dysfunction, and discussing the clinical application and existing problems of microvesicles for better translational applications.

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Tanshinone IIA inhibits the adipogenesis and inflammatory response in ox‐LDL‐challenged human monocyte‐derived macrophages via regulating miR‐130b/WNT5A

Limei

Zhang

Liu

et al. 2019

J of Cellular Biochemistry

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Atherosclerosis is a kind of chronic cardiovascular disease, characterized by oxidized low‐density lipoprotein (ox‐LDL) accumulation in macrophage. Tanshinone IIA (Tan), a lipophilic pharmacologically activate compound from Salvia miltiorrhiza Bunge, has been indicated to exert cardioprotective roles. Nevertheless, the biological role of Tan and regulatory mechanism in atherosclerosis are not fully established. In present study, atherosclerosis model was established in THP‐1‐derived macrophages by treatment of ox‐LDL. The adipogenesis was measured by Nile red staining. The expressions of inflammatory factors, microRNA‐130b (miR‐130b) and WNT5A were measured by quantitative real‐time polymerase chain reaction or Western blot. The target association between miR‐130b and WNT5A was explored via luciferase activity and RNA immunoprecipitation assay. The results showed that exposure of Tan inhibited ox‐LDL‐induced adipogenesis and expressions of interleukin‐1β (IL‐1β), IL‐6, and tumor necrosis factor‐alpha in THP‐1‐derived macrophages. miR‐130b expression was decreased in THP‐1‐derived macrophages treated by ox‐LDL and its overexpression attenuated adipogenesis as well as inflammatory response. miR‐130b knockdown reversed the regulatory effect of Tan on adipogenesis and inflammatory response in THP‐1‐derived macrophages stimulated by ox‐LDL. In addition, WNT5A acted as a functional target of miR‐130b and inhibited by Tan and miR‐130b. As a conclusion, Tan decreased the adipogenesis and inflammatory response by mediating miR‐130b and WNT5A, providing a novel theoretical foundation for treatment of atherosclerosis.

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The salient role of microRNAs in atherogenesis

Cited by 27 publications

References 175 publications

Changes in circulating microRNA and arterial stiffness following high‐intensity interval and moderate intensity continuous exercise

Changes in circulating microRNA and arterial stiffness following high‐intensity interval and moderate intensity continuous exercise

The role of microvesicles containing microRNAs in vascular endothelial dysfunction

Tanshinone IIA inhibits the adipogenesis and inflammatory response in ox‐LDL‐challenged human monocyte‐derived macrophages via regulating miR‐130b/WNT5A

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