The saga of diagnostic/classification criteria in Behcet's disease

Davatchi, Fereydoun; Abdollahi, Bahar Sadeghi; Chams‐Davatchi, Cheyda; Shahram, Farhad; Shams, Hormoz; Nadji, Abdolhadi; Faezi, Tahereh; Akhlaghi, Maassoumeh; Ghodsi, Zahra; Mohtasham, Nooshin; Ashofteh, Farimah

doi:10.1111/1756-185x.12520

Cited by 70 publications

(57 citation statements)

References 21 publications

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“…Up to now, there are 17 sets of C/D criteria [65], As seen by the two upper mentioned studies, ICBD is superior to ISG in sensitivity and the accuracy. The difference in specificity is by far inferior to the difference in sensitivity and in accuracy.…”

Section: Diagnosismentioning

confidence: 99%

Behcet’s disease: epidemiology, clinical manifestations, and diagnosis

Davatchi

Chams‐Davatchi

Shams

et al. 2016

Expert Review of Clinical Immunology

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281

190

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Behcet's Disease (BD) is classified among vasculitides. The aim of this review was to put together different known reports in order to help the reader to better understand the disease, to avoid the frequent misdiagnosis, and to decide the best treatment. Areas covered: a) Epidemiology: BD is rare, and is seen along the Silk Road, from 20 to 420/100,000 in Turkey and 80/100,000 in Iran, to 0.64/100,000 in the UK. b) Clinical manifestations: oral aphthosis is seen in more than 95% of patients, genital aphthosis (60-90%), skin (pseudofolliculitis/erythema nodosum, 40-90%), eyes (uveitis/retinal vasculitis, 45-90%), gastrointestinal (diarrhea/hemorrhage/perforation/pain, 4-38%), vascular (venous/arterial thrombosis, aneurysm, 2.2-50%), neurological (all kinds, especially meningo-encephalitis, 2.3-38.5%), and articular (arthralgia/arthritis/ankylosing spondylitis, 11.6-93%). c) Pathergy test is positive in some patients: 8.6% (in India) to 70.7% (in China). This data was extracted from the five nationwide surveys and the largest case series from BD conference reports and a Pubmed search. Expert commentary: Diagnosis is clinical but classification/diagnosis criteria may help. The best criteria for BD is the International Criteria for Behcet's Disease (ICBD). BD is a multisystem disease progressing by attacks and remissions. Each attack may resemble the preceding or it may be different in duration, severity, and the systems involved.

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Section: Diagnosismentioning

confidence: 99%

Behcet’s disease: epidemiology, clinical manifestations, and diagnosis

Davatchi

Chams‐Davatchi

Shams

et al. 2016

Expert Review of Clinical Immunology

Self Cite

281

190

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“…1,2 It most commonly affects Mediterranean and East Asian ethnic groups and generally starts between 20-35 years of age. 3,4 Although the etiopathogenesis of BD has not been completely identified, it is considered to be manifested due to intense inflammatory response triggered by an infectious agent in individuals having genetic predisposition.…”

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confidence: 99%

Endocan Measurement for Active Behçet Disease

et al. 2017

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Objectives: This study aims to investigate the relationships between serum endocan, vascular endothelial growth factor (VEGF), and tumor necrosis factor-alpha (TNF-α) levels in active Behçet disease. Patients and methods: Forty patients with active Behçet disease (24 males, 16 females; mean age 37.6±8.7 years; range 20 to 50 years) and 40 healthy controls (22 males, 18 females; mean age 38.8±7.9 years; range 21 to 52 years) were included in this study. Both patient and control groups underwent a complete systemic and ophthalmic examination by the same specialist. Endocan, VEGF, and TNF-α levels were measured with an enzyme-linked immunosorbent assay kit in all subjects. Results: Serum endocan levels were 775.2±479.3 ng/mL and 275.8±145.8 ng/mL in the patient and control groups, respectively. VEGF levels were 1768.2±900.5 pg/mL and 980.2±135.3 pg/mL in the patient and control groups, respectively. TNF-α levels were 22.4±74.3 pg/mL-1 and 11.4±16.9 pg/mL-1 in the patient and control groups, respectively. There was a statistically significant difference between groups in terms of serum endocan, VEGF, and TNF-α levels. There was a significant positive correlation between serum endocan and VEGF levels in the patient group (r=0.630; p<0.001). Also, there was a significant positive correlation between serum endocan and TNF-α levels in the patient group (r=0.713; p<0.001). Conclusion: Serum endocan level may be a new marker in evaluation of both the prognosis and activity of Behçet disease.

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“…К этому следует добавить, что диагностика болезни Бехчета основывается на совокупности клас-сификационных/диагностических признаков, развитие которых может быть растянутым на 5-6 и более лет [14,15]. О сложности верификации диагноза свидетель-ствует описание 17 вариантов диагностических/квали-фикационных критериев болезни Бехчета [16].…”

Section: Introductionunclassified

“…В биохимическом анализе сыворотки крови име-лась диспротеинемия: альбумин 48,98% (норма 53,0-68,0), альфа-1 глобулин -6,26% (норма 1,6-4,5), аль-фа-2 -23,01% (норма 5,7-11,5), бета -12,05% (норма 8,0-14,2), гамма -9,70% (норма 10, [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]5).…”

Section: Introductionunclassified

Juvenile Behсet's Disease: Clinical Observation

Соботюк¹,

Кононов²,

Бочанцев³

et al. 2016

Vopr. sovr. pediatr.

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ВВЕДЕНИЕВерификация воспалительных заболеваний кишеч-ника (ВЗК) представляет для клинициста трудную диаг -ностическую задачу. Это обусловлено схожестью кли-ни ческих симптомов заболеваний кишечника, мно го-образием вариантов клинических проявлений, от сут -ствием определенных этиологических факторов, надеж-ных лабораторных тестов и, в ряде случаев, отличи-тельных гистологических признаков [1]. Встречающиеся наиболее часто в клинической практике врача детского гастроэнтеролога язвенный колит и болезнь Крона даже при использовании современных методов диагностики не всегда удается разграничить. Это обусловлено тем, что у детей, в отличие от взрослых, болезнь Крона чаще ассоциируется с поражением толстого кишечника (коли-том) и в меньшей степени -с илеитом [2]. Биоптаты,

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The saga of diagnostic/classification criteria in Behcet's disease

Cited by 70 publications

References 21 publications

Behcet’s disease: epidemiology, clinical manifestations, and diagnosis

Behcet’s disease: epidemiology, clinical manifestations, and diagnosis

Endocan Measurement for Active Behçet Disease

Juvenile Behсet's Disease: Clinical Observation

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