The safety of tea agarwood (Aquilaria malaccensis) from tree induction through test of toxicity subchronic oral 90 days

Abstract

Batubara R, Surjanto, Sihombing TM, Ginting H. 2016. The safety of tea agarwood (Aquilaria malaccensis) from tree induction throuht test of toxicity subcronic oral 90 days. Biofarmasi 14: 69-76. Subchronic toxicity test is a test to detect the toxic effect that arises after the administration of the test reparation with repeated doses were given orally to the tested animal for 28 or 90 days. Leaves agarwood (Aquilaria malaccensis Lamk) is a tree from a tribe Thymeleaceae, already started popular used the farmer agarwood in Langkat as a drink that in pour. The result of an interview with the farmer agarwood explained that consume tea from the leaves agarwood of this kind of have many benefits include improve canal. To that was done the research security against the tea leaves agarwood induction taken from agriculture agarwood in Langkat, Sumatera North through test toxic subchronic oral. This study aims to determine the symptoms of toxic posed by product tea agarwood induction. This study used laboratory animals that male mice and female mice were divided into 5 groups, namely the 130, 260, 390, 520 mg/kgBW and the control group. The observation of clinical symptoms indicate the presence of toxic symptoms of weakness, changes in fur and agitated at doses of 390 and 520 mg/kgBW in male mice and female mice, the observation macropathology organs alloxan still normal the red-brown, the surface of slippery and consistency chewy. Histopathological results showed hemoglia and dilation of the blood vessels in all groups. Results showed that mice were given tea steeping agarwood induction doses ranging from 130, 260,390 and 520 mg/kgBW there are no mice died, so it can be concluded that the administration of agarwood tea steeping in mice does not cause toxic symptoms and safe for consumption.

Ameliorative Effects of Aquilaria malaccensis Leaves Aqueous Extract on Reproductive Toxicity Induced by Cyclophosphamide in Male Rats

“…Generally, AM leaves aqueous extract administration is considered safe and the AM dosage should not cause any negative effects on sperm. Previous study indicated that AM leaves extract administration up to 520 mg kg −1 daily for 90 days in male mice does not cause any toxic signs and symptoms and is safe for consumption (61). The LD50 of the leaf extract was also found to be above 2000 mg kg −1 (62).…”

The antioxidant activities and chemical compounds of Aquilaria crassna, Aquilaria microcarpa, and Gyrinops versteegii leaves growing in Langkat, North Sumatra, Indonesia

“…On the other hand, the n-hexane extract exhibited weak antioxidant compounds with a total phenol of 0.45% (Wahyuningrum et al 2018). Batubara et al (2018) conducted studies on acute and subchronic toxicity tests (Batubara et al 2016), revealing that agarwood tea was safe for consumption. However, leaf utilization needs further investigation to advance development, especially regarding raw material variations.…”

The screening of phytochemical and antioxidant activity of agarwood leaves (Aquilaria malaccensis) from two sites in North Sumatra, Indonesia

“…Agarwood leaves contain chemical compounds such as flavonoids, flavones, flavonols, and isoflavones. These chemical compounds are categorized as antioxidant sources (Surjanto et al 2015), and safe for consumption (Batubara et al 2016).…”