The safety and efficacy of autologous adipose-derived stromal vascular fraction for nonscarring alopecia: A systematic review

Kang, Bianca Y.; Li, Alvin W.; Lee, Ming H.; Wong, Clarissa; Naseer, N.; Ibrahim, Sarah A.; Miller, Corinne H.; Keimig, E.; Poon, Emily; Alam, Murad

doi:10.1007/s00403-021-02238-7

Cited by 6 publications

(7 citation statements)

References 13 publications

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“…In line with several studies, 14,15,22 pain during injection and headache being the most common side effects.…”

Section: Discussionsupporting

confidence: 81%

“…This study indicated that SVF could effectively treat non‐scarring hair loss without serious complications. The study observed that the extent of the effectiveness of this treatment potentially depends on many variables, including the severity and underlying cause of the patient's alopecia, frequency of treatment, concomitant treatments, and preparation methods 22 …”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the effects of adding an adipose tissue‐derived stromal vascular fraction to platelet‐rich plasma injection in the treatment of androgenetic alopecia: A randomized clinical trial

Behrangi,

Rahimi,

Zare

et al. 2024

Skin Research and Technology

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BackgroundStromal vascular fraction (SVF) cells derived from adipose tissue and platelet‐rich plasma (PRP) are among novel treatments for androgenetic alopecia (AGA). We aimed to investigate the effect of adding SVF to PRP and compare it to administering PRP injection alone.MethodsEighteen patients were randomly divided into two groups of nine. The PRP group was treated with PRP at all three visits at 1‐month intervals, while the SVF‐PRP group received an SVF injection on the first visit and a PRP injection on the second and third visits. Each group was evaluated at baseline and 20 weeks after the therapy's initiation.ResultsChanges in mean hair diameter and hair count compared to baseline were significant in both groups. The PRP group experienced a greater increase in mean hair count than the SVF‐PRP group, and the SVF‐PRP group had a marginally greater increase in hair diameter than the PRP group. These differences were not statistically significant compared to each other. The patient and physician assessment scores exceeded the mean (on a scale from 0: poor to 3: excellent) in both groups.ConclusionAdding one SVF injection to two PRP treatment sessions versus three PRP injections alone had no significant difference in evaluated variables. If additional research demonstrates the same results, we suggest that multiple SVF injection sessions may be required to produce a statistically significant difference compared to PRP injection alone. Moreover, considering lower cost and greater accessibility of PRP, it can be used before SVF in the treatment of AGA.

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“…In line with several studies, 14,15,22 pain during injection and headache being the most common side effects.…”

Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Evaluation of the effects of adding an adipose tissue‐derived stromal vascular fraction to platelet‐rich plasma injection in the treatment of androgenetic alopecia: A randomized clinical trial

Behrangi,

Rahimi,

Zare

et al. 2024

Skin Research and Technology

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“…5 Finally, a recent systematic review including 188 patients with non-scarring alopecia found hair density improvement with SVF compared with control or baseline in all studies. 6 No severe adverse events were reported. Additional trials are necessary to strengthen the understanding of the efficacy and safety of SVF for AA treatment.…”

Section: Regenerative Therapies In Alopecia Areatamentioning

confidence: 95%

Regenerative therapies in alopecia areata

Christensen

Anvery

Dirr

2022

J of Cosmetic Dermatology

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“…278 Overall, systematic revision of human clinical studies has proven the efficacy of ADSC therapy but underlined that its outcome varies depending on hair loss severity, method of SVF preparation, frequency of patient treatment, and the use of adjunctive therapies. 279 ADSCs action is explained by the production 270,280,281 Wnt3a is involved in hair follicle advancement through stimulation Wnt/β-catenin signalling a pathway that is deeply involved in anagen initiation. 282 The central role of the Wnt/β-catenin pathway in hair biology is also demonstrated by its mobilization after stimulation in hair follicle cells with almost all growth factors.…”

Section: Hair Lossmentioning

confidence: 99%

“…In a study reported by Gentile, 33 patients were successfully managed with an autologous solution obtained from mechanical fragmentation and centrifugation of intra‐ and extra‐human dermal adipose aissue‐derived hair follicle stem sells (HD‐AFSCs) 278 . Overall, systematic revision of human clinical studies has proven the efficacy of ADSC therapy but underlined that its outcome varies depending on hair loss severity, method of SVF preparation, frequency of patient treatment, and the use of adjunctive therapies 279 . ADSCs action is explained by the production of bioactive factors implicated in the hair growth cycle and hair differentiation such as IGF, VEGF, HGF, PDGF and Wnt pathway regulating factors 270,280,281 …”

Section: Introductionmentioning

confidence: 99%

Therapeutic potential of adipose tissue‐derivatives in modern dermatology

Bellei

Migliano

Picardo

2022

Experimental Dermatology

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Stem cell‐mediated therapies in combination with biomaterial and growth factor‐based approaches in regenerative medicine are rapidly evolving with increasing application beyond the dermatologic field. Adipose‐derived stem cells (ADSCs) are the more frequently used adult stem cells due to their abundance and easy access. In the case of volumetric defects, adipose tissue can take the shape of defects, restoring the volume and enhancing the regeneration of receiving tissue. When regenerative purposes prevail on volume restoration, the stromal vascular fraction (SVF) rich in staminal cells, purified mesenchymal stem cells (MSCs) or their cell‐free derivatives grafting are favoured. The therapeutic efficacy of acellular approaches is explained by the fact that a significant part of the natural propensity of stem cells to repair damaged tissue is ascribable to their secretory activity that combines mitogenic factors, cytokines, chemokines and extracellular matrix components. Therefore, the secretome's ability to modulate multiple targets simultaneously demonstrated preclinical and clinical efficacy in reversing pathological mechanisms of complex conditions such atopic dermatitis (AD), vitiligo, psoriasis, acne and Lichen sclerosus (LS), non‐resolving wounds and alopecia. This review analysing both in vivo and in vitro models gives an overview of the clinical relevance of adipose tissue‐derivatives such as autologous fat graft, stromal vascular fraction, purified stem cells and secretome for skin disorders application. Finally, we highlighted the major disease‐specific limitations and the future perspective in this field.

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The safety and efficacy of autologous adipose-derived stromal vascular fraction for nonscarring alopecia: A systematic review

Cited by 6 publications

References 13 publications

Evaluation of the effects of adding an adipose tissue‐derived stromal vascular fraction to platelet‐rich plasma injection in the treatment of androgenetic alopecia: A randomized clinical trial

Evaluation of the effects of adding an adipose tissue‐derived stromal vascular fraction to platelet‐rich plasma injection in the treatment of androgenetic alopecia: A randomized clinical trial

Regenerative therapies in alopecia areata

Therapeutic potential of adipose tissue‐derivatives in modern dermatology

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