The rs1256031 of estrogen receptor β gene is associated with type 2 diabetes

Herrera-Lopez, Ema E.; Castelán-Martínez, Osvaldo Daniel; Suárez‐Sánchez, Fernando; Gómez-Zamudio, Jaime; Peralta‐Romero, Jesús; Cruz, Miguel; Valladares‐Salgado, Adán

doi:10.1016/j.dsx.2018.04.018

Cited by 8 publications

(4 citation statements)

References 12 publications

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“…In addition, increasing BMI was associated with a decreased risk of ERb-cyto (-) tumors, but was not associated with ERb-cyto (þ) tumors. Interestingly, genetic variation in ERb is associated with risk of type 2 diabetes (23). Furthermore, in skin punch biopsies from postmenopausal women, higher adiposity was associated with lower expression of ERb (24).…”

Section: Discussionmentioning

confidence: 99%

Estrogen Receptor-β Expression of Ovarian Tumors and Its Association with Ovarian Cancer Risk Factors

Shafrir

Babić

Kuliszewski

et al. 2020

Cancer Epidemiology, Biomarkers &Amp; Prevention

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◥Background: Differential associations between ovarian cancer risk factors and estrogen receptor-a (ERa) ovarian tumor expression have been noted; however, no research has assessed estrogen receptor-b (ERb) expression. Thus, in exploratory analyses, we assessed the association of several factors with ovarian cancer risk by ERb tumor status.Methods: We conducted a nested case-control study within the prospective Nurses' Health Study cohorts (NHS/NHSII), with exposures collected through biennial questionnaires. Paraffinembedded tumor blocks were requested for cases diagnosed from 1976 to 2006 (NHS) and 1989 to 2005 (NHSII) and tissue microarrays were stained for nuclear ERb (ERb-nuc) and cytoplasmic ERb (ERb-cyto), with any staining considered positive (þ). We obtained odds ratios (OR) and 95% confidence intervals (CI) using multivariate polytomous logistic regression.Results: We included 245 cases [43% ERb-cyto (þ) and 71% ERb-nuc (þ)] and 1,050 matched controls. An inverse associa-tion was observed between parity and risk of ERb-nuc (þ) (OR, parous vs. nulliparous: 0.46; 95% CI, 0.26-0.81), but not ERb-nuc (-) tumors (OR, parous vs. nulliparous: 1.51; 95% CI, 0.45-5.04; P heterogeneity ¼ 0.04). Conversely, parity was inversely associated with ERb-cyto (-) tumors (OR, parous vs. nulliparous: 0.42; 95% CI, 0.23-0.78), but was not associated with ERb-cyto (þ) tumors (OR, parous vs. nulliparous: 1.08; 95% CI, 0.45-2.63; P heterogeneity ¼ 0.05). Associations for other exposures, including hormone therapy, did not differ by ERb-nuc or ERbcyto status.Conclusions: Our results suggest that parity may influence ovarian cancer risk, in part, through alterations in ERb localization within tumor cells.Impact: Alterations in ERb expression and localization appear to be important for ovarian cancer etiology. Future research should confirm our results and assess potential biologic mechanisms for the observed associations.

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Section: Discussionmentioning

confidence: 99%

Estrogen Receptor-β Expression of Ovarian Tumors and Its Association with Ovarian Cancer Risk Factors

Shafrir

Babić

Kuliszewski

et al. 2020

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…This report indicated that the recessive model of ESR2 rs1256031 gene polymorphism was correlated with a reduction of ocular disease risk, which has been also reported as a protective factor in developing type 2 diabetes mellitus. 28 Mice lacking ERβ are more susceptible to in vivo injury to RPE cells 29 , which supports a protective effect of ERβ. It has been reported that the expression of ERβ is more abundant than ERα in the central nervous system 2 , 4 , 30 , including the retina.…”

Section: Discussionmentioning

confidence: 78%

The Association Between Genetic Polymorphisms in Estrogen Receptor Genes and the Risk of Ocular Disease: A Meta-Analysis

Ulhaq¹

2020

tjo

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Objectives: To evaluate the association between estrogen receptor (ER) genes polymorphisms and the risk of ocular disease. Materials and Methods: A meta-analysis was performed of all available studies that investigated the association between ER gene polymorphisms and the risk of ocular disease. Results: Studies that were selected based on inclusion criteria reported 5 and 4 single-nucleotide polymorphisms (SNPs) identified in the ESR1 (ERα) (rs2234093, rs12154178, rs1884054, rs1801132, and rs9340799) and ESR2 (ERβ) (rs1268656, rs7159462, rs1256031, and rs4986938) genes, respectively. The pooled result showed a significant association between ESR2 rs1256031 gene polymorphism and ocular disease (odds ratio: 0.55, 95% confidence interval: 0.41-0.74, p<0.0001). Conclusion: The recessive genotype of ESR2 rs1256031 gene polymorphism had a protective effect against ocular disease, which supports the hypothesis that the estrogen-signaling pathway through ERβ plays a pivotal role in the pathogenesis of ophthalmic disorders.

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“…ESR2, TRIM25, ELAVL1, and HNRNPL, were frequently targeted based on the Interactome neighborhood. Among the commonly hit network neighborhood genes, ESR2, coding for an estrogen receptor, was linked to obesity and diabetes (23,24). TRIM25, coding for a ubiquitin ligase enzyme, was shown to suppress adipocyte differentiation, thus, it was also linked to obesity and diabetes (25).…”

Section: Discussionmentioning

confidence: 99%

Random SNP Events for Diabetes and Their Molecular Interaction Neighborhood

Dalgiç¹

2019

Turk J Diab Obes

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Genomik çalışmalar, tip 2 diabetes mellitus (T2DM) dahil olmak üzere, birçok hastalık ve diğer fenotiplerle önemli ilişkileri olan Tek Nükleotid Polimorfizmleri koleksiyonu sunmaktadır. T2DM ilişkili SNP olaylarının frekansı genom düzeyinde rastgeleleştirme analiziyle incelenebilir. SNP olayları ile eşleştirilen genlere dayanarak, moleküler etkileşim düzeyindeki etkiler incelenebilir. Gereç ve Yöntemler: İnsan genomu için rastgele SNP olayları oluşturuldu. Farklı T2DM ilişkili SNP olaylarının frekansları incelendi. SNP olaylarıyla eşleştirilmiş genler elde edildi ve bu genlerin doğrudan moleküler etkileşim komşuları incelendi. Ayrıca İnsülin Sinyalleşmesi (IS) Yolağının, T2DM ilişkili SNP olaylarının hedefinde olup olmadığı kontrol edildi. Bulgular: En az bir adet T2DM ilişkili SNP'nin rastgele olarak gözlemlenmesi olası olarak bulundu. Ağ komşuluğu göz önüne alındığında, rastgele SNP olaylarının etkisi genişledi. Bazı SNP'ler ve bunlarla eşleştirilmiş olan genler, diğerlerine göre daha sıkça hedeflendi. IS Yolağı üyeleri nadiren hedeflendi, ancak ağ komşuluğu bu yolağa olan etkiyi de genişletti. Sonuç: Bireysel genomlarda rastgele beklenen varyasyonlar diyabet duyarlılığını muhtemelen etkiler. Ağ düzeyi etkileşimler genomik varyasyonların etkisini genişletir.

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The rs1256031 of estrogen receptor β gene is associated with type 2 diabetes

Cited by 8 publications

References 12 publications

Estrogen Receptor-β Expression of Ovarian Tumors and Its Association with Ovarian Cancer Risk Factors

Estrogen Receptor-β Expression of Ovarian Tumors and Its Association with Ovarian Cancer Risk Factors

The Association Between Genetic Polymorphisms in Estrogen Receptor Genes and the Risk of Ocular Disease: A Meta-Analysis

Random SNP Events for Diabetes and Their Molecular Interaction Neighborhood

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