The roles of titanium surface micro/nanotopography and wettability on the differential response of human osteoblast lineage cells

Gittens, Rolando A.; Olivares-Navarrete, René; Cheng, Aijie; Anderson, David M.; McLachlan, Taylor; Stephan, Ingrid; Geis‐Gerstorfer, Jürgen; Sandhage, Kenneth H.; Fedorov, Andrei G.; Rupp, Frank; Boyan, Barbara D.; Tannenbaum, Rina; Schwartz, Zvi

doi:10.1016/j.actbio.2012.12.002

Cited by 254 publications

(218 citation statements)

References 38 publications

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“…There are many reports describing the relationship between microscale surface roughness and osteoblast differentiation. Although there is no clear consensus about the optimal microscale roughness for osteoblast differentiation, osteoblasts generally favor rough surfaces with Ra values of about 3-5 µm above smooth surfaces with Ra values <1 µm 20,27,28) . In vivo studies have shown that rough surfaces with Ra values in 3-5 µm are more suitable for osteointegration than smooth surfaces 16,17) .…”

Section: Discussionmentioning

confidence: 99%

Bioactive treatment promotes osteoblast differentiation on titanium materials fabricated by selective laser melting technology

et al. 2016

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Selective laser melting (SLM) technology is useful for the fabrication of porous titanium implants with complex shapes and structures. The materials fabricated by SLM characteristically have a very rough surface (average surface roughness, Ra=24.58 µm). In this study, we evaluated morphologically and biochemically the specific effects of this very rough surface and the additional effects of a bioactive treatment on osteoblast proliferation and differentiation. Flat-rolled titanium materials (Ra=1.02 µm) were used as the controls. On the treated materials fabricated by SLM, we observed enhanced osteoblast differentiation compared with the flat-rolled materials and the untreated materials fabricated by SLM. No significant differences were observed between the flat-rolled materials and the untreated materials fabricated by SLM in their effects on osteoblast differentiation. We concluded that the very rough surface fabricated by SLM had to undergo a bioactive treatment to obtain a positive effect on osteoblast differentiation.

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Section: Discussionmentioning

confidence: 99%

Bioactive treatment promotes osteoblast differentiation on titanium materials fabricated by selective laser melting technology

et al. 2016

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“…production on combined nano/microrough titanium surfaces, but human MSCs exhibited a less robust response (Gittens et al 2013). Because all surfaces were relatively hydrophobic in this study, the impact of surface energy in comparison to that of nanotopography is unknown.…”

Section: Multiscale Surface Roughnessmentioning

confidence: 91%

Implant Surface Design Regulates Mesenchymal Stem Cell Differentiation and Maturation

et al. 2016

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Changes in dental implant materials, structural design, and surface properties can all affect biological response. While bulk properties are important for mechanical stability of the implant, surface design ultimately contributes to osseointegration. This article reviews the surface parameters of dental implant materials that contribute to improved cell response and osseointegration. In particular, we focus on how surface design affects mesenchymal cell response and differentiation into the osteoblast lineage. Surface roughness has been largely studied at the microscale, but recent studies have highlighted the importance of hierarchical micron/submicron/nanosurface roughness, as well as surface roughness in combination with surface wettability. Integrins are transmembrane receptors that recognize changes in the surface and mediate downstream signaling pathways. Specifically, the noncanonical Wnt5a pathway has been implicated in osteoblastic differentiation of cells on titanium implant surfaces. However, much remains to be elucidated. Only recently have studies been conducted on the differences in biological response to implants based on sex, age, and clinical factors; these all point toward differences that advocate for patient-specific implant design. Finally, challenges in implant surface characterization must be addressed to optimize and compare data across studies. An understanding of both the science and the biology of the materials is crucial for developing novel dental implant materials and surface modifications for improved osseointegration.

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“…Some works demonstrated the impact of wettability and roughness on directing mesenchymal stem cells toward the osteogenic lineage. Therefore, the osteogenic lineage fate can be modulated by means of suitable surface characteristics of topography and wettability [113][114][115][116]. Using LST, exogenous soluble factors could be avoided.…”

Section: Challenges and Future Trendsmentioning

confidence: 99%

Laser Surface Texturing of Polymers for Biomedical Applications

et al. 2018

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Polymers are materials widely used in biomedical science because of their biocompatibility, and good mechanical properties (which, in some cases, are similar to those of human tissues); however, these materials are, in general, chemically and biologically inert. Surface characteristics, such as topography (at the macro-, micro, and nano-scale), surface chemistry, surface energy, charge, or wettability are interrelated properties, and they cooperatively influence the biological performance of materials when used for biomedical applications. They regulate the biological response at the implant/tissue interface (e.g., influencing the cell adhesion, cell orientation, cell motility, etc.). Several surface processing techniques have been explored to modulate these properties for biomedical applications. Despite their potentials, these methods have limitations that prevent their applicability. In this regard, laser-based methods, in particular laser surface texturing (LST), can be an interesting alternative. Different works have showed the potentiality of this technique to control the surface properties of biomedical polymers and enhance their biological performance; however, more research is needed to obtain the desired biological response. This work provides a general overview of the basics and applications of LST for the surface modification of polymers currently used in the clinical practice (e.g., PEEK, UHMWPE, PP, etc.). The modification of roughness, wettability, and their impact on the biological response is addressed to offer new insights on the surface modification of biomedical polymers.

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The roles of titanium surface micro/nanotopography and wettability on the differential response of human osteoblast lineage cells

Cited by 254 publications

References 38 publications

Bioactive treatment promotes osteoblast differentiation on titanium materials fabricated by selective laser melting technology

Bioactive treatment promotes osteoblast differentiation on titanium materials fabricated by selective laser melting technology

Implant Surface Design Regulates Mesenchymal Stem Cell Differentiation and Maturation

Laser Surface Texturing of Polymers for Biomedical Applications

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