The roles of microRNAs in Wilms’ tumors

Yu, Xin; Li, Zheng; Chan, Matthew T. V.; Wu, William Ka Kei

doi:10.1007/s13277-015-4514-8

Cited by 22 publications

(22 citation statements)

References 73 publications

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“…indicates that miRs are dysregulated in WT, implying that miRNAs may have important roles in WT progression [Yu et al, 2016]. is an important member of the miR family and participates in various human cancers, including prostate cancer, colorectal cancer, and lung cancer [Ponomaryova et al, 2016;Stuopelyte et al, 2016;Zekri et al, 2016].…”

mentioning

confidence: 99%

Retracted: Effects of MicroRNA‐19b on the Proliferation, Apoptosis, and Migration of Wilms’ Tumor Cells Via the PTEN/PI3K/AKT Signaling Pathway

Liu

Yang

Liu

et al. 2017

J of Cellular Biochemistry

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Wilms' tumor (WT) is a most common renal cancer that occurs among children, and microRNA-19b (miR-19b) usually participates in various human cancers. Importantly, the PTEN/PI3K/Akt signaling pathway plays a key role in cell apoptosis, growth and proliferation. Thus, our present study aims to investigate the effect of miR-19b on the PTEN/PI3K/Akt signaling pathway during WT cell proliferation, migration, and apoptosis. WT tissues and adjacent normal tissues from WT patients were collected. qRT-PCR was applied to detect miR-19b expression in both the WT tissues and the adjacent normal tissues, immunohistochemistry was applied to detect the protein expressions of PTEN, P13K, and p-Akt, SK-NEP-1 cells were divided into the blank, negative control (NC), miR-19b mimics and miR-19b inhibitors groups. MTT assay, propidium iodide (PI) staining, Annexin-V/PI double-staining, Transwell assay and Western blotting were performed to examine cell proliferation, cycle, apoptosis, migration, and invasion, and the protein expressions of PTEN, P13K, Akt, and p-Akt. Increased miR-19b expression, positive expression rates of P13K and Akt, decreased PTEN expression rate, a negative correlation between PTEN expression and tumor lymph node metastasis, and a positive correlation between the expression of P13K and Akt and the clinical stages were observed in the WT tissues. The miR-19b inhibitors group exhibited decreased cell proliferation, cell cycle progression, migration and invasion, and protein expressions of PI3K and p-Akt but increased PTEN protein expression compared with the blank and NC groups. Thus, inhibition of miR-19b suppresses the progression of WT by modulating the PTEN/PI3K/AKT signaling pathway. J. Cell. Biochem. 118: 3424-3434, 2017. © 2017 Wiley Periodicals, Inc.

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mentioning

confidence: 99%

Retracted: Effects of MicroRNA‐19b on the Proliferation, Apoptosis, and Migration of Wilms’ Tumor Cells Via the PTEN/PI3K/AKT Signaling Pathway

Liu

Yang

Liu

et al. 2017

J of Cellular Biochemistry

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“…MEIS1 was upregulated in a model of WT. As a predicted upstream regulator of MEIS1, MiRNA-204 expression was significantly decreased in all WT samples compared with normal renal parenchyma 40 .…”

Section: Down-regulated Micrornasmentioning

confidence: 92%

“…MicroRNAs are involved in many biological processes, such as development, growth, and metabolism. It is also being increasingly demonstrated that miRNAs are dysregulated in WT, suggesting that miRNAs may be important in WT pathogenesis 40– 42 .…”

Section: Micrornasmentioning

confidence: 99%

“…IGF2, a fetal growth factor, has been shown to increase cell proliferation and promote tumor development and is aberrantly increased in WT. MiR-483-3p is upregulated in 100% of WTs, and a functional positive feedback loop between miR-483-5p and IGF2 has been suggested 40 .…”

Section: Upregulated Micrornasmentioning

confidence: 99%

“…The SIX1 homeobox protein plays a significant role during development, and it has been shown to be the direct target of miR-185 and exhibit an inverse correlation with miR-185 in WT and normal matched control kidney tissues 40 .…”

Section: Down-regulated Micrornasmentioning

confidence: 99%

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Recent advances in the management of Wilms' tumor

Lopes

Lorenzo

2017

F1000Res

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The objective of this article is to present an overview of recent trends in the management of Wilms’ tumor. With improved survival rates in the past few decades, critical long-term adverse therapy effects (such as renal insufficiency, secondary malignancies, and heart failure) and prevention measures (i.e. nephron-sparing surgery and minimizing the use of radiotherapy) have gained worldwide attention. Specific disease biomarkers that could help stratify high-risk from low-risk patients, and therefore fine-tune management, are in great demand. Ultimately, we aim to enhance clinical outcomes and maintain or improve current survival rates while avoiding undesirable treatment side effects and minimizing the exposure and intensity of chemotherapy and radiotherapy.

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