The roles of glucose metabolic reprogramming in chemo- and radio-resistance

Abstract

Reprogramming of cancer metabolism is a newly recognized hallmark of malignancy. The aberrant glucose metabolism is associated with dramatically increased bioenergetics, biosynthetic, and redox demands, which is vital to maintain rapid cell proliferation, tumor progression, and resistance to chemotherapy and radiation. When the glucose metabolism of cancer is rewiring, the characters of cancer will also occur corresponding changes to regulate the chemo- and radio-resistance of cancer. The procedure is involved in the alteration of many activities, such as the aberrant DNA repairing, enhanced autophagy, oxygen-deficient environment, and increasing exosomes secretions, etc. Targeting altered metabolic pathways related with the glucose metabolism has become a promising anti-cancer strategy. This review summarizes recent progress in our understanding of glucose metabolism in chemo- and radio-resistance malignancy, and highlights potential molecular targets and their inhibitors for cancer treatment.

miR-27a is a master regulator of metabolic reprogramming and chemoresistance in colorectal cancer

“…miR-27a affects the response to chemotherapy Metabolic rewiring of cancer cells and cancer pathways activate mechanisms implicated in chemoresistance. 6,7 We, therefore, asked whether miR-27a was able to influence the CRC treatment response. Our in silico analysis of the TCGA-COAD dataset revealed that miR-27a expression was higher in the CRCs resistant to therapy (i.e.…”

Metabolic Reprogramming of Sulfur in Hepatocellular Carcinoma and Sulfane Sulfur-Triggered Anti-Cancer Strategy

“…Metabolic reprogramming is a distinctive hallmark of cancer. The reprogrammed glucose metabolism in tumorigenesis has been studied for many years (Kato et al, 2018;Lin et al, 2019). Additionally, the metabolism of amino acids, such as cysteine, homocysteine, glutamine, and methionine, are attracting increased attention in recent years (Gao et al, 2019;Lieu et al, 2020).…”

Flavonoids against the Warburg phenotype—concepts of predictive, preventive and personalised medicine to cut the Gordian knot of cancer cell metabolism

“…It is well established that the increase of glucose uptake and lactate secretion due to metabolic changes in malignant cells constitutes the Warburg effect, an essential step of carcinogenesis [2]. Alterations in glucose metabolism associated with dramatically increased proliferation activity, progression and development of chemo-/ radioresistance represent an important hallmark of malignancy [216]. Due to metabolic reprogramming, cancer cells exhibit increased levels of glucose uptake.…”