The role of β-carotene as preventive agent against harmful UV-effects on the skin

Gollnick, Harald; Hemmes, Christian; Chun, Soo-Kyung; Sundermeier, K.; Hopfenmoller, W.; Biesalski, H. K.

doi:10.1097/00008390-199309002-00067

Cited by 4 publications

(7 citation statements)

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“…Concerning the discussed beneficial effect of β‐carotene in skin exposed to sunlight, it has been reported that β‐carotene acts only in part as an optical filter [32]. β‐Carotene is supposed to act mainly as quencher of activated oxygen species in the skin and this property was attributed to its photoprotective effects in vitro [20] and in vivo [3]. In contrast, instead of a suppression of the oxidative stress‐derived HO‐1 cascade, we identified an increase in cutaneous UVA stress response.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding normal skin, several reports exist showing short‐term photoprotective effects of β‐carotene supplementation, e.g. decreased formation of erythema [3,4], whereas others show no beneficial effects [5–7]. The influence of β‐carotene on photocarcinogenesis was reported to be preventive [8], but in contrast to these findings, some authors described ineffectiveness [9] or even exacerbation of tumour development by β‐carotene [10].…”

Section: Introductionmentioning

confidence: 99%

“…The influence of β‐carotene on photocarcinogenesis was reported to be preventive [8], but in contrast to these findings, some authors described ineffectiveness [9] or even exacerbation of tumour development by β‐carotene [10]. As exposure to natural or artificial sunlight is steadily increasing as a result of changing leisure habits and environmental conditions, the intake of dietary β‐carotene supplements to support the effect of sunscreens has been recommended [3].…”

Section: Introductionmentioning

confidence: 99%

“…Few data exist about how β‐carotene acts in vitro in skin exposed to ultraviolet (UV) light. It has been supposed that β‐carotene might act as an antioxidant [3] defeating UVA‐generated cutaneous oxidative stress [11]. Although knowledge about the modulation of UV effects in skin cells by antioxidants is limited, cellular antioxidant defence mechanisms seem to be crucial to the prevention of oxidative UV skin damage [12].…”

Section: Introductionmentioning

confidence: 99%

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Enhancement of the UVA induction of haem oxygenase‐1 expression by β‐carotene in human skin fibroblasts

et al. 1999

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L L-Carotene has often been discussed as a means to reduce the risk of skin photodamage. We studied the antioxidative potential of L L-carotene in human skin fibroblasts exposed to ultraviolet A light. Surprisingly, we found a pro-oxidative effect of L L-carotene. Using the induction of haem oxygenase-1 as a marker for oxidative stress, we found a strong enhancement of gene expression by L L-carotene in ultraviolet A-irradiated cells. This effect was clearly suppressed by concomitant addition of vitamin E but only moderately by vitamin C. The results show that L L-carotene has pro-oxidative properties in human skin fibroblasts exposed to ultraviolet-A light.z 1999 Federation of European Biochemical Societies.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Enhancement of the UVA induction of haem oxygenase‐1 expression by β‐carotene in human skin fibroblasts

et al. 1999

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“…However, our data are currently only based on findings in those subjects with skin type I-IV in plasma and the oral mucosa. On the other hand, we know from data of our BerlinEilath study that female volunteers with skin type III had higher ß-carotene levels in skin than those with type I/II [10,11,14,15]. Data for skin type-associated correlations in type V or VI (black skin, Australian aborigines) could not be found in the literature and had not been studied yet by us.…”

Section: Discussionmentioning

confidence: 95%

β-Carotene Plasma Levels and Content in Oral Mucosal Epithelium Is Skin Type Associated

Gollnick

Siebenwirth²

2002

Skin Pharmacol Physiol

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β-Carotene is one of the important antioxidants in the defence mechanisms of the body against reactive oxygen species and, in particular, against UV radiation in the skin. The aim of our study was to measure if differences of β-carotene in the peripheral blood and oral mucosa exist in relation to skin types I–IV (according to Fitzpatrick). One hundred and seventy-four subjects were studied with regard to β-carotene plasma levels. Out of these, 63 healthy volunteers (24–28 years) with skin type I–IV were studied with regard to plasma levels and content of β-carotene in the oral mucosa. Ten millilitres of venous blood was obtained and oral mucosa cells (OMCs) were taken by gently brushing the oral cavity without contamination of capillary leak blood. A modified method by Stich et al. was used for preparing cells and measuring β-carotene in OMCs by HPLC. Plasma levels of skin type I were 0.1565 µmol/l and increased via skin types II with 0.2989 and III with 0.5457 to 1.221 µmol/l in skin type IV. A similar skin type-dependent increase in β-carotene could be measured in the oral mucosa epithelium (OMC) either when measured in micromoles/litre (0.0056–0.0217) or in nanograms/10⁶ cells (0.2090–0.9989). Smokers had significantly lower levels of β-carotene in plasma and OMC as compared with non-smokers. Non-melanoma and melanoma skin cancer patients also showed lower β-carotene plasma levels and in the OMCs as well. From our results, we conclude that plasma levels and content of β-carotene in the cytoplasm of OMCs show marked and significant differences with regard to skin types I–IV. The question arises whether these differences are genetically controlled.

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The effect of β‐carotene on the expression of interleukin‐6 and heme oxygenase‐1 in UV‐irradiated human skin fibroblasts in vitro

Obermüller-Jevic¹,

Schlegel²,

Flaccus³

et al. 2001

FEBS Letters

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L L-Carotene is discussed as an anti-oxidant micronutrient and singlet oxygen quencher in human skin, protecting against UV light-induced damage. However, we recently demonstrated that L L-carotene has a pro-oxidant potential in cultured human skin fibroblasts because it enhances the UVA induction of heme oxygenase-1 (HO-1). Herein, we further show that L L-carotene also strongly promotes the UVA induction of pro-inflammatory interleukin-6 (IL-6) in skin fibroblasts in vitro. Singlet oxygen quencher sodium azide abrogated up-regulation of IL-6, and likewise also of HO-1. In UVB-irradiated cells, L L-carotene did not modulate levels of IL-6 and HO-1. The observed effects might be relevant for UV-induced inflammatory processes. ß

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The role of β-carotene as preventive agent against harmful UV-effects on the skin

Cited by 4 publications

References 0 publications

Enhancement of the UVA induction of haem oxygenase‐1 expression by β‐carotene in human skin fibroblasts

Enhancement of the UVA induction of haem oxygenase‐1 expression by β‐carotene in human skin fibroblasts

β-Carotene Plasma Levels and Content in Oral Mucosal Epithelium Is Skin Type Associated

The effect of β‐carotene on the expression of interleukin‐6 and heme oxygenase‐1 in UV‐irradiated human skin fibroblasts in vitro

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