The Role of Wine in Modulating Inflammatory Processes: A Review

Lorenzo, Chiara Di; Stockley, Creina S.; Colombo, Francesca; Biella, S.; Orgiu, F.; Dell’Agli, Mario; Restani, Patrizia

doi:10.3390/beverages4040088

Cited by 3 publications

(1 citation statement)

References 49 publications

(111 reference statements)

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“…When LPS binds to TLR4 on the surface of macrophages, a signal transduction cascade leading to transcription of specific enzymes, such as COX2, matrix metalloproteinase-9, and inflammatory cytokines TNF-α, IL-1, IL-6, IL-8, and chemokines [38]. The NF-κB pathway plays a central role for the protective properties of a moderate wine consumption [39]. Therefore, we evaluated if the red wine powder from Aglianico del Vulture will affect the NF-κB pathway.…”

Section: Effect On Expression Promoter Activity and Nuclearmentioning

confidence: 99%

Phenolic Compounds of Red Wine Aglianico del Vulture Modulate the Functional Activity of Macrophages via Inhibition of NF-κB and the Citrate Pathway

Santarsiero

Convertini

Vassallo

et al. 2021

Oxidative Medicine and Cellular Longevity

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Phenolic compounds of red wine powder (RWP) extracted from the Italian red wine Aglianico del Vulture have been investigated for the potential immunomodulatory and anti-inflammatory capacity on human macrophages. These compounds reduce the secretion of IL-1β, IL-6, and TNF-α proinflammatory cytokines and increase the release of IL-10 anti-inflammatory cytokine induced by lipopolysaccharide (LPS). In addition, RWP restores Annexin A1 levels, thus involving activation of proresolutive pathways. Noteworthy, RWP lowers NF-κB protein levels, promoter activity, and nuclear translocation. As a consequence of NF-κB inhibition, reduced promoter activities of SLC25A1—encoding the mitochondrial citrate carrier (CIC)—and ATP citrate lyase (ACLY) metabolic genes have been observed. CIC, ACLY, and citrate are components of the citrate pathway: in LPS-activated macrophages, the mitochondrial citrate is exported by CIC into the cytosol where it is cleaved by ACLY in oxaloacetate and acetyl-CoA, precursors for ROS, NO⋅, and PGE2 inflammatory mediators. We identify the citrate pathway as a RWP target in carrying out its anti-inflammatory activity since RWP reduces CIC and ACLY protein levels, ACLY enzymatic activity, the cytosolic citrate concentration, and in turn ROS, NO⋅, PGE2, and histone acetylation levels. Overall findings suggest that RWP potentially restores macrophage homeostasis by suppressing inflammatory pathways and activating proresolutive processes.

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Section: Effect On Expression Promoter Activity and Nuclearmentioning

confidence: 99%

Phenolic Compounds of Red Wine Aglianico del Vulture Modulate the Functional Activity of Macrophages via Inhibition of NF-κB and the Citrate Pathway

Santarsiero

Convertini

Vassallo

et al. 2021

Oxidative Medicine and Cellular Longevity

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Enhancing wine shelf-life: Insights into factors influencing oxidation and preservation

Mercanti,

Macaluso,

Pieracci

et al. 2024

Heliyon

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Chemical Composition and Polyphenolic Compounds of Red Wines: Their Antioxidant Activities and Effects on Human Health—A Review

et al. 2021

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Red wine, an alcoholic beverage is composed of a spectrum of complex compounds such as water, alcohol, glycerol, organic acid, carbohydrates, polyphenols, and minerals as well as volatile compounds. Major factors that affect the levels of phenolic compounds in red wines are the variety of grapes and the storage of the wines. Among the constituents of red wine, phenolic compounds play a crucial role in attributes including color and mouthfeel and confer beneficial properties on health. Most importantly, phenolic compounds such as flavanols, flavonols, flavanones, flavones, tannins, anthocyanins, hydroxycinnamic acids, hydroxybenzoic acids, and resveratrol can prevent the development of cardiovascular diseases, cancers, diabetes, inflammation, and some other chronic diseases.

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The Role of Wine in Modulating Inflammatory Processes: A Review

Cited by 3 publications

References 49 publications

Phenolic Compounds of Red Wine Aglianico del Vulture Modulate the Functional Activity of Macrophages via Inhibition of NF-κB and the Citrate Pathway

Phenolic Compounds of Red Wine Aglianico del Vulture Modulate the Functional Activity of Macrophages via Inhibition of NF-κB and the Citrate Pathway

Enhancing wine shelf-life: Insights into factors influencing oxidation and preservation

Chemical Composition and Polyphenolic Compounds of Red Wines: Their Antioxidant Activities and Effects on Human Health—A Review

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