The Role of Vitamins and Trace Elements on Oral Health: A Systematic
                    Review

Shaik, Parveen Sultana; Pachava, Srinivas

doi:10.29252/ijmr-040105

Cited by 12 publications

(6 citation statements)

References 50 publications

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“…Vitamin D has been related to gingival inflammation [47] and tooth loss [17,19,20,25,33,35,36]. Moreover, vitamins and in particular vitamin D as a promising oral health-preventive agent were the object of several previous reviews [73][74][75][76][77], systematic [74][75][76] and narrative [73,77] leading to a low-certainty conclusion that vitamins may reduce the incidence of caries and periodontitis.…”

Section: Discussionmentioning

confidence: 99%

The Role of Vitamins in Oral Health. A Systematic Review and Meta-Analysis

Cagetti

Wolf

Tennert

et al. 2020

IJERPH

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The association between vitamins and oral health have recently been discussed, yielding increased attention from medical and dental perspectives. The present review aimed to systematically evaluate and appraise the most recently scientific papers investigating the role of vitamins in the prevention and treatment of the main oral diseases as hard dental pathological processes and gum/periodontal disease. Randomized controlled trials, cross-sectional studies, cohort studies, comparative studies, validation studies and evaluation studies, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, reporting associations between vitamins and oral diseases or the use of vitamins to prevent or treat oral diseases in patients of any age were included. PubMed, Embase and Scopus were searched to November 2019 using an ad hoc prepared search string. All the papers meeting the inclusion criteria were subjected to a quality assessment. The search identified 1597 papers; 741 were selected after removing duplicates. A total of 334 articles were excluded after title and abstract evaluation; 407 were assessed and 73 papers were full-text assessed; other 14 papers were discharged after full text evaluation, leaving finally 58 papers included. In general, there is weak evidence supporting the association between vitamins and both gingival/periodontal disease and hard dental pathological processes.

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Section: Discussionmentioning

confidence: 99%

The Role of Vitamins in Oral Health. A Systematic Review and Meta-Analysis

Cagetti

Wolf

Tennert

et al. 2020

IJERPH

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“…As mentioned, vitamin C contributes to collagen synthesis, which is an important protein for providing tooth structure, support, and maintenance (25,26). Vitamin C induces calcium deposition, mineralization, and reduces the risk of developing secondary caries in children (27). In a meta-analysis conducted to review dietary factors associated with dental erosion, Li et al revealed that chewing vitamin C tablets was significantly associated with tooth wear development (28) partly due to its low pH.…”

Section: Vitamin C and Oral Healthmentioning

confidence: 99%

Beneficial Effects of Vitamin C in Maintaining Optimal Oral Health

et al. 2022

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Vitamin C, also known as ascorbic acid, is typically obtained from the diet. Small amounts of water-soluble vitamin C are needed to maintain normal body functions (1-3). Vitamin C has been broadly recognized as the most important hydrophilic antioxidant and is a specific cofactor for many enzymatic reactions. Most plants and animals can synthesize vitamin C from D-glucose and D-galactose. However, due to the absence of the enzyme L-gulonolactone oxidase (GLO) in humans and some animal species such as monkeys, guinea pigs, bats, and birds, they are unable to generate endogenous forms of vitamin C (2, 4). For that reason, humans must obtain vitamin C from their diet or take supplements because a total deficiency of vitamin C in humans can result in spongy swollen bleeding gums, dry skin, open sores on the skin, fatigue, impaired wound healing, and depression. Scurvy can occur when healthy individuals consume <10 mg of vitamin C per day. Additionally, some cancers, anemias, and infections have been linked to a vitamin C deficiency (3,5,6). Ascorbic acid is sensitive to air, light, and heat, thus can be destroyed by overcooking and storing food for prolonged periods. In addition, vitamin C is not stored in the body, which is the reason why it must be regularly consumed.The highest levels of vitamin C can be found in the brain and neuroendocrine tissues (7). Ascorbic acid is essential for the maintenance of collagen, which represents almost one-third of the body's total proteins. Collagen is a constituent protein of bones, cartilages, ligaments, cornea and eye lenses, skin, intervertebral discs, teeth, tendons, gums, blood vessels, and heart valves. Ascorbic acid is also essential for the synthesis of muscle carnitine (β-hydroxybutyric acid), which is necessary for the transport of fatty acids in mitochondria for energy production. Ascorbic acid is needed to synthesize catecholamines and ensure optimal functions of oxytocin, vasopressin, cholecystokinin, and alpha-melanotropin (8). Small amounts of ascorbic acid can prevent against the development of scurvy, and the accumulation of high levels of ascorbate in the plasma and tissues has been found to protect against oxidative damage and limit inflammation (8, 9). As previously mentioned, vitamin C concentration is higher in the brain compared to other organs; therefore, it is likely to contribute to maintaining cognitive functions (10). In newborns, vitamin C deficiency leads to memory impairments due to the decreased neurons in the hippocampus (11). In the elderly, optimum vitamin C levels can help reduce the intensity of many degenerative diseases such as Parkinson's disease, perhaps by manipulating dopamine regulation (12,13). Vitamin C deficiency also contributes to a higher risk of stroke and associated complications in the elderly (10,11). It has also been found that smokers are at a higher risk of developing a vitamin C deficiency and may require an additional 35 mg/day of vitamin C to be able to maintain proper vitamin C functions (13).Another clinically import...

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“…Therefore, an endeavor to maintain optimal conditions and enhance oral health necessitates the implementation of supplemental nutritional therapy, which is beneficial to the patients [ 11 ]. There are positive associations between particular nutrients, such as calcium, vitamins C and D, and periodontal health [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Nonsurgical Treatment of Periodontitis in Menopausal Patients: A Randomized Control Trial

Eldessouky,

Marie

2024

BioMed Research International

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Background. Menopause is typically accompanied by significant systemic and oral manifestations, including hormonal changes and increased susceptibility to periodontal disease, which may involve inflammatory biomarkers like aspartate aminotransferase (AST) and osteocalcin in gingival crevicular fluid (GCF). The study is aimed at evaluating the effectiveness of regular inoculation of polyunsaturated fatty acids (PUFAs) as an adjunctive treatment for menopausal women’s periodontitis. Methods. Twenty elderly women with chronic periodontitis were split evenly into two groups by random assignment. Patients in group II (the research group) were given soft gelatin capsules containing PUFAs to be consumed directly once daily for 12 months, as opposed to group I (the control group), who received soft gelatin capsules containing some olive oil (placebo). Scaling and root planning (SRP) were used to address periodontal disease in all cases. Results. At baseline, six and twelve months after treatment, clinical indicators and AST and osteocalcin amounts in the GCF were noted. By the conclusion of the research period, all observed clinical measurements had changed significantly and improved. In addition, there had been a significant decrease in AST levels and a nonsignificant decrease in osteocalcin levels in group II compared to group I. Conclusions. Menopausal women with periodontitis who take omega-3 fatty acid supplements in addition to SRP have better oral health. Significant improvements in clinical indicators and a notable decrease in AST levels within the GCF were observed. However, further research with larger cohorts and extended duration is needed to validate these findings and explain potential mechanisms. This trial is registered with NCT06254118.

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The Role of Vitamins and Trace Elements on Oral Health: A Systematic Review

Cited by 12 publications

References 50 publications

The Role of Vitamins in Oral Health. A Systematic Review and Meta-Analysis

The Role of Vitamins in Oral Health. A Systematic Review and Meta-Analysis

Beneficial Effects of Vitamin C in Maintaining Optimal Oral Health

Nonsurgical Treatment of Periodontitis in Menopausal Patients: A Randomized Control Trial

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