The role of Vitamin D3 in breast cancer prevention: A literature review

Abstract

Breast cancer is one of the most common malignancies with a high mortality rate worldwide, including in Kazakhstan. Despite modern advanced di-agnosis and treatment methods, breast cancer remains one of the top three “killer cancers.” Treatment with immunoglobulins and modern targeted chemotherapy agents is efficient but does not reduce breast cancer incidence. High treatment cost, antitumor drug resistance occurring during therapy, and significant side ef-fects of chemotherapy urge the importance of prophylactic actions to prevent the tumor disease.
 The purpose of the study was to review the Vitamin D3 role and potential in breast cancer prevention.
 Results: The analysis of the literature reviews and original articles accessing the Vitamin D3 role in breast cancer pathogenesis and the study of the main anti-tumor mechanisms of Vitamin D3 action emphasize the need for large randomized prospective studies to determine the actual Vitamin D3 role in breast cancer pathogenesis and its possible inclusion in antitumor
 therapy regimens.
 Conclusion: The results obtained evidence on the Vitamin D3 adjuvant potential in breast cancer treatment.