The role of vitamin D and vitamin D deficiency in orthopaedics and traumatology—a narrative overview of the literature

Abstract

Vitamin D is considered to play an important role in musculoskeletal health. It's classical function is the regulation of calcium and phosphate homeostasis, thus ensuring a balanced bone metabolism that is characterised by an equal amount of bone resorption and bone formation. In the past decades, a plethora of pre-clinical and clinical studies reporting on potential health-beneficial properties of vitamin D have emerged. Moreover, there is an abundance of reports highlighting vitamin D deficiency and insufficiency in patients with almost innumerable diseases. Further, it is estimated that more than one billion people globally are affected by insufficient vitamin D levels. As such, research on vitamin D has been particularly popular over the past years. In orthopaedics and traumatology, most studies describe favourable effects of vitamin D in general. However, the relative importance of vitamin D is oftentimes debated. In this narrative review of the literature, we consider first, the properties of vitamin D and how vitamin D, vitamin D deficiency and the vitamin D receptor (VDR) impact on musculoskeletal health. Secondly, we provide an overview of studies reporting the prevalence of vitamin D deficiency in traumatology and diverse orthopaedic diseases including bone oncology. Lastly, we emphasise recent findings and touch on future perspectives in vitamin D research.

Effect of Vitamins A, E, D3 Supplemented with Omega3 and Vitamins A, E, D3 (without Omega -3) on Biochemical Blood Parameters of Females Awassi Lamb

“…Table (11) showed there had not significant increased between control and treatment groups, While T3 had significant increase in G1 as comported with T2,…”

“…Vitamins are essential organic food compounds that the body needs in few quantities. have an important physiological action their deficiency leads to disruption of metabolic processes, disruption of vital processes in the body, Vitamin D3 regulate homeostasis levels of magnesium, calcium and phosphate, its deficiency causes rickets, it has a role in action of parathyroid hormone secretion, intestine, kidney and bone tissues [9][10][11][12]. so, this study was designed to investigation the effect of vitamins A, E, D3 and vitamins A, E, D3 supplemented with Omega 3 on biochemical blood parameters of females Awassi lamb.…”

Vitamin D Metabolic Pathway Components in Orthopedic Patientes—Systematic Review

“…The complex then binds to vitamin D responsive elements in the regulatory region of the target genes. We now know that almost all tissues and cells in the body have VDRs and that several of them have the enzymatic ability to convert the primary circulating form of 25(OH)D into its active form [ 29 ]. The importance of VDR in orthopedic problems was the subject of research by Muraki et al (2011) [ 30 ].…”

Vitamin D Deficiency Is Frequent in Patients with Rapidly Destructive Osteoarthritis—Data from a Single-Center Analysis

“…Over the past decades, research on vitamin D has been progressively more popular, which has led to a plethora of studies investigating potential health-beneficial effects of vitamin D [ 15 , 32 , 33 , 34 ]. Consequently, it is now known that vitamin D impacts a multitude of diseases, including many orthopaedic disorders [ 16 , 35 , 36 , 37 , 38 ]. Thus, it is conceivable that vitamin D deficiency might also play a role in the onset and progression of RDO.…”