Vitamin D Metabolic Pathway Components in Orthopedic Patientes—Systematic Review

Abstract

Vitamin D takes part in the functioning of many processes that ensure the homeostasis of the body. In orthopedics, it is indicated as an inseparable element ensuring proper bone growth and functioning, and its deficiencies are indicated in various diseases, mainly in the proper structure and function of the skeleton. In this review, we focus on the most important components of the vitamin D metabolic pathway, in correlation with selected orthopedic conditions. Records were obtained from the PubMed database in a timeline of 2010–2022. The keywords were as follows: vitamin D/cholesterol/vitamin D binding protein/ VDBP/Cytochrome/CYP24A1/CYP 27B1/Vitamin D receptor/VDR/ + diseases (ACL reconstruction, rotator cuff, arthroplasty knee/hip/shoulder). The recent original studies were analyzed, discussed, and the most important data were shown. The vast majority of articles concern the metabolite of vitamin D (25(OH)D), which is measured as a standard in diagnostic laboratories. Even though there is a lot of valuable information in the literature, we believe that the other elements of the vitamin D pathway also deserve attention and suggest their research in correlation with orthopedic disorders to supplement the missing knowledge on this topic.

Vitamin D Deficiency As A Contributor To Atherosclerosis Development – A Review

“…Activated vitamin D sterols therapy in vivo led to a decrease in D3 levels in plasma due to powerful induction of the vitamin D catabolic pathway. These discoveries correspond with the observations that CYP24A1 gene polymorphisms, which can reduce levels of 25-hydroxy vitamin D, correlate with high CAC (Płomiński et al, 2022). Hereby, provision of vitamin D repletion can facilitate paracrine and autocrine calcitriol production in CV tissues, thus triggering activation of VC inhibitory pathways that depend on calcitriol receptor.…”