The Role of Vitamin D Binding Protein, Total and Free 25-Hydroxyvitamin D in Diabetes

Jorde, Rolf

doi:10.3389/fendo.2019.00079

Cited by 19 publications

(9 citation statements)

References 72 publications

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“…In addition to being the carrier protein for vitamin D and its metabolites, it is implicated in the pathogenesis of T2D. In particular, vitamin D-binding protein is involved in the inflammatory process because it activates the T-cell response that may lead to the development of type 1 diabetes (T1D) and T2D [54]. Diabetes-induced changes in vitamin D-binding protein turnover could be used to evaluate the effect of vitamin D supplementation on the prevention or treatment diabetes.…”

Section: Discussionmentioning

confidence: 99%

Temporal Dynamics of High-Density Lipoprotein Proteome in Diet-Controlled Subjects with Type 2 Diabetes

et al. 2020

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We examined the effect of mild hyperglycemia on high-density lipoprotein (HDL) metabolism and kinetics in diet-controlled subjects with type 2 diabetes (T2D). 2H2O-labeling coupled with mass spectrometry was applied to quantify HDL cholesterol turnover and HDL proteome dynamics in subjects with T2D (n = 9) and age- and BMI-matched healthy controls (n = 8). The activities of lecithin–cholesterol acyltransferase (LCAT), cholesterol ester transfer protein (CETP), and the proinflammatory index of HDL were quantified. Plasma adiponectin levels were reduced in subjects with T2D, which was directly associated with suppressed ABCA1-dependent cholesterol efflux capacity of HDL. The fractional catabolic rates of HDL cholesterol, apolipoprotein A-II (ApoA-II), ApoJ, ApoA-IV, transthyretin, complement C3, and vitamin D-binding protein (all p < 0.05) were increased in subjects with T2D. Despite increased HDL flux of acute-phase HDL proteins, there was no change in the proinflammatory index of HDL. Although LCAT and CETP activities were not affected in subjects with T2D, LCAT was inversely associated with blood glucose and CETP was inversely associated with plasma adiponectin. The degradation rates of ApoA-II and ApoA-IV were correlated with hemoglobin A1c. In conclusion, there were in vivo impairments in HDL proteome dynamics and HDL metabolism in diet-controlled patients with T2D.

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Section: Discussionmentioning

confidence: 99%

Temporal Dynamics of High-Density Lipoprotein Proteome in Diet-Controlled Subjects with Type 2 Diabetes

et al. 2020

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“…In another study involving 1189 nondiabetic subjects, free and total 25(OH)D levels were positively associated with acute insulin response and glucose disposition index; however, after adjustment for BMI, only the free fraction of vitamin D was found to be related to the secretion of insulin [40]. In turn, Jorde reviewed the relationship between 25(OH)D, free25(OH)D, and VDBP concentrations and the occurrence of type-2 diabetes, finding that measures of total 25(OH)D as well as of the free fraction of this vitamin in diabetic patients may serve as new biomarkers for the development and treatment of this disorder [41]. In our study, the obese hypertensive patients did not show any correlations between vitamin D fractions and glucose levels, so we cannot confirm these findings.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Vitamin D Fractions in Obese Hypertensive Patients

Pelczyńska

Grzelak

Sperling

et al. 2020

IJERPH

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Vitamin D fractions can be involved in the pathogenesis of metabolic disorders, but their concentrations are rarely determined. The aim of this study was to evaluate the concentration of vitamin D fractions in obese hypertensive patients and to determine its associations with anthropometric parameters, glucose levels, and lipid profiles. A total of 85 obese hypertensive patients (OBHT) and 40 nonobese nonhypertensive subjects (NOBNHT) underwent biochemical measurements of lipid profiles, glycemia, 25-hydroxyvitamin D (25(OH)D), free vitamin D (free25(OH)D), vitamin D binding protein, albumin levels. Moreover, free25(OH)D and bioavailable25(OH)D (bio25(OH)D) concentrations were calculated. Blood pressure and anthropometric measurements were performed. Differences between groups (p < 0.001) were found for 25(OH)D (OBHT 40.25 ± 18.02 vs. NOBNHT 64.10 ± 22.29 nmol/L), free25(OH)D (9.77 (7.46; 11.49) vs. 13.80 (10.34; 16.82) pmol/L), bioavailable 25(OH)D (3.7 (2.8; 4.4) vs. 5.4 (4.2; 6.7) nmol/L), and calculated free25(OH)D (7.82 (5.54; 11.64) vs. 10.46(8.06;16.28) pmol/L, p = 0.002). The OBHT patients showed no relationship between vitamin D fractions concentration and glucose or lipids level, although it was associated with anthropometric parameters. In the NOBNHT group, vitamin D fractions correlated positively with HDL cholesterol and negatively with triglyceridemia and hip circumference. Vitamin D fractions were decreased in obese hypertensive subjects, and were associated with anthropometric parameters, but not with glucose level or lipid profiles; they thus cannot be considered as a predictive marker of metabolic disorders in this group of patients.

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“…The polymorphisms of DBP have been associated with susceptibility or resistance to a large number of chronic conditions, such as osteoporosis [40][41][42], type 1 and type 2 diabetes [43], thyroid autoimmunity [44], inflammatory bowel disease [45], and chronic obstructive lung disease [46]. Furthermore, it plays a role in infectious diseases [47][48][49].…”

Section: Discussionmentioning

confidence: 99%

Sedeprovid, a novel vitamin D based substance, plus AlphaH℗ lead to complete recovery from COVID-19 within 48 hours after application in a 7-months old baby, a 1.5-year-old toddler and three further adults

Herwig¹,

Tp²,

Greilberger³

et al. 2020

J Transl Sci

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Aim: Coronavirus Disease (COVID-19) is caused by the newly emerged coronavirus SARS-CoV-2. To prevent further spread of SARS-CoV-2 and to provide a possible prophylaxis and treatment option we report about our experience on the application of two preparations with a clinical complete recovery of five patients, including two breastfed babies, from a Coronavirus disease with severe symptoms.Material and methods: Sedeprovid (ImmunoD ® CLS ℗ ) were applied twice a day and AlphaH ℗ 20 ml concentrate was consumed once a day in the morning. The course of disease and symptoms before, during and after treatment were recorded.Results: Prior to treatment, the patients suffered from severe symptoms of confirmed COVID-19 infections, including cough, inappetence, tiredness, bone and body pain, loss of taste and smell and body temperature of ≥39ºC for several days.Within 24 hours after application of ImmunoD ® CLS ℗ and AlphaH ℗ a significant reduction of symptoms and a drop down of maximal body temperature was recorded. A complete recovery with normal body temperature and normal or close to normal activity was documented after 48 hours. No side effects were reported from the patients or the parents. Conclusion:The combination of ImmunoD ® CLS ℗ and AlphaH ℗ might offer a good treatment regimen for COVID-19 infected patients with moderate and severe disease progression before entering or after leaving the ICU ward. In addition, this protocol might be used as a prophylactic therapy option for healthcare providers.We strongly recommend the instant confirmation of these results in a controlled randomized trial for a possible rapid benefit of COVID-19 infected patients. Herwig R (2020) Sedeprovid, a novel vitamin D based substance, plus AlphaH ℗ lead to complete recovery from COVID-19 within 48 hours after application in a 7-months old baby, a 1.5-year-old toddler and three further adults

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The Role of Vitamin D Binding Protein, Total and Free 25-Hydroxyvitamin D in Diabetes

Cited by 19 publications

References 72 publications

Temporal Dynamics of High-Density Lipoprotein Proteome in Diet-Controlled Subjects with Type 2 Diabetes

Temporal Dynamics of High-Density Lipoprotein Proteome in Diet-Controlled Subjects with Type 2 Diabetes

Evaluation of Vitamin D Fractions in Obese Hypertensive Patients

Sedeprovid, a novel vitamin D based substance, plus AlphaH℗ lead to complete recovery from COVID-19 within 48 hours after application in a 7-months old baby, a 1.5-year-old toddler and three further adults

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