The role of visfatin (PBEF/Nampt) in pregnancy complications

Pavlová, Tereza; Novák, J; Bienertová-Vašků, Julie

doi:10.1016/j.jri.2015.09.004

Cited by 26 publications

(13 citation statements)

References 88 publications

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“…In the current study, NAMPT plus MAP and parity generated a model with similar predictive power: AUC of 0.82 for all preeclampsia cases. Nampt protein levels have been reported to be either elevated or reduced in women with preeclampsia [ 30 ]. Tarca et al [ 31 ] reported an mRNA discovery study using whole blood and microarrays.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of a Maternal Plasma RNA Panel Predicting Spontaneous Preterm Birth and Its Expansion to the Prediction of Preeclampsia

et al. 2022

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Preterm birth is the principal contributor to neonatal death and morbidity worldwide. We previously described a plasma cell-free RNA panel that between 16 and 20 weeks of pregnancy had potential to predict spontaneous preterm birth (sPTB) ≤ 32 weeks caused by preterm labor (PTL) or preterm premature rupture of membranes (PPROM). The present study had three objectives: (1) estimate the RNA panel prognostic accuracy for PTL/PPROM ≤ 32 weeks in a larger series; (2) improve accuracy by adding clinical characteristics to the predictive model; and (3) examine the association of the RNA panel with preeclampsia. We studied 289 women from Memphis TN prospectively sampled 16.0–20.7 weeks and found: (1) PSME2 and Hsa-Let 7g were differentially expressed in cases of PTL/PPROM ≤ 32 weeks and together provided fair predictive accuracy with AUC of 0.76; (2) combining the two RNAs with clinical characteristics improved good predictive accuracy for PTL/PPROM ≤ 32 weeks (AUC 0.83); (3) NAMPT and APOA1 were differentially expressed in women with ‘early-onset preeclampsia’ (EOP) and together provided good predictive accuracy with AUC of 0.89; and (4) combining the two RNAs with clinical characteristics provided excellent predictive accuracy (AUC 0.96). Our findings suggest an underlying common pathophysiological relationship between PTL/PPROM ≤ 32 weeks and EOP and open inroads for the prognostication of high-risk pregnancies.

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Section: Discussionmentioning

confidence: 99%

Evaluation of a Maternal Plasma RNA Panel Predicting Spontaneous Preterm Birth and Its Expansion to the Prediction of Preeclampsia

et al. 2022

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“…Visfatin is thought to upregulate activity of NAD-dependent deacetylase sirtuin-1, an enzyme which influences insulin secretion in response to increase in glucose level [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Adipokine Profile in Patients with Type 2 Diabetes Depends on Degree of Obesity

Kocot

Dziemidok²,

Kiełczykowska

et al. 2017

Med Sci Monit

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BackgroundThe fast pace of life, promoting fast food consumption and low physical activity, has resulted in obesity and/or diabetes as being serious social problems.The aim of the present study was to evaluate concentrations of selected adipokines (leptin, adiponectin, resistin, and visfatin) and to assess the leptin/adiponectin ratio in plasma of type 2 diabetes (T2D) patients in relation to degree of obesity.Material/MethodsThe study comprised 92 T2D subjects divided into 4 groups according to BMI value – I (normal body weight), II (overweight), III (obesity), and IV (severe obesity) – and 20 healthy volunteers (control group). Each group was divided into male and female subgroups. Plasma concentrations of adipokines were determined by enzyme-linked immunosorbent assay.ResultsIn women, leptin concentration was significantly higher in group IV, whereas in men it was higher in groups III and IV than in the control group and groups I and II. Irrespective of sex, a significant decrease in adiponectin level was observed in group III vs. control. There was no significant difference in resistin levels. In women visfatin was markedly enhanced in group III, whereas in men in groups II, III and IV vs. control. Leptin/adiponectin ratio was increased in groups III and IV vs. control in women, whereas in men vs. both control and group I.ConclusionsThe obese type 2 diabetic patients presented a disturbed adipokine profile, which seems to be an important link between obesity and T2D. The future studies concerning the question if regulating of adipokines’ concentrations could be a promising approach for managing metabolic disorders seem to be well-grounded.

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“…Visfatin is a newly discovered adipocyte hormone in 2004 that it is predominantly produced and secreted in visceral fat (Fukuhara et al, 2005). However, it was subsequently demonstrated to be expressed in almost every tissue of the human body (Curat et al, 2006;Varma et al, 2007;Costford et al, 2010;Garten et al, 2010;Pavlova et al, 2015). Later, visfatin was found involved and correlated with inflammatory phenomena, atheroslcerosis and insulin secretion (Chen et al, 2006;Curat et al, 2006;Dogru et al, 2007;Varma et al, 2007;Aller et al, 2009;Liu et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Effects of Palm-Based High-Oleic Blended Cooking Oil Diet on Selected Biomarkers of Inflammation and Obesity Compared to Extra Virgin Olive Oil Diet in Overweight Malaysian Adults

Lee¹

2018

JOPR

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High-oleic blended cooking oil (HOBO) comprises palm olein and canola oil, with more than 50% of monounsaturated oleic acid. Studies on the effects of HOBO on human health is limited and therefore, this study compared the effects of HOBO, extra virgin olive oil (OO) and coconut oil (CO) on biomarkers of inflammation, obesity and blood pressure in 32 overweight but otherwise healthy Malaysian adults. Subjects were randomised to receive three different dietary sequences, each comprising three six-week dietary periods with three-week washouts in between, utilising a double-crossover design. The HOBO, OO, and CO test fats were incorporated at 20% kcal into a background diet providing 30% kcal as total fat, 15% kcal as protein, and 55% kcal from carbohydrates. At the end of the dietary interventions, there were no significant differences (p > 0.05) observed on the effects of the three test fats on all the outcome variables measured-anthropometric indices [body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR)], serum biomarkers of obesity (serum leptin, visfatin) and inflammation [tumour necrosis factor alpha (TNF-α), interleukin 6 (IL6), high-sensitivity C-reactive protein (hsCRP)].

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The role of visfatin (PBEF/Nampt) in pregnancy complications

Cited by 26 publications

References 88 publications

Evaluation of a Maternal Plasma RNA Panel Predicting Spontaneous Preterm Birth and Its Expansion to the Prediction of Preeclampsia

Evaluation of a Maternal Plasma RNA Panel Predicting Spontaneous Preterm Birth and Its Expansion to the Prediction of Preeclampsia

Adipokine Profile in Patients with Type 2 Diabetes Depends on Degree of Obesity

Effects of Palm-Based High-Oleic Blended Cooking Oil Diet on Selected Biomarkers of Inflammation and Obesity Compared to Extra Virgin Olive Oil Diet in Overweight Malaysian Adults

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