Effects of Palm-Based High-Oleic Blended Cooking Oil Diet on Selected Biomarkers of Inflammation and Obesity Compared to Extra Virgin Olive Oil Diet in Overweight Malaysian Adults

Abstract

High-oleic blended cooking oil (HOBO) comprises palm olein and canola oil, with more than 50% of monounsaturated oleic acid. Studies on the effects of HOBO on human health is limited and therefore, this study compared the effects of HOBO, extra virgin olive oil (OO) and coconut oil (CO) on biomarkers of inflammation, obesity and blood pressure in 32 overweight but otherwise healthy Malaysian adults. Subjects were randomised to receive three different dietary sequences, each comprising three six-week dietary periods with three-week washouts in between, utilising a double-crossover design. The HOBO, OO, and CO test fats were incorporated at 20% kcal into a background diet providing 30% kcal as total fat, 15% kcal as protein, and 55% kcal from carbohydrates. At the end of the dietary interventions, there were no significant differences (p > 0.05) observed on the effects of the three test fats on all the outcome variables measured-anthropometric indices [body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR)], serum biomarkers of obesity (serum leptin, visfatin) and inflammation [tumour necrosis factor alpha (TNF-α), interleukin 6 (IL6), high-sensitivity C-reactive protein (hsCRP)].

Olive oil and body fat: a systematic review withmeta-analysis

“…The characteristics of the included studies are shown in Table 1. Among the 52 studies selected, 44 7,17–21,28–66 are randomized clinical trials with a parallel design and eight 67–74 have a crossover design. The samples of the included studies ranged from 23 to 351 participants, with a mean age ranging from 23 to 79 years.…”

A Review of Key Sustainability Issues in Malaysian Palm Oil Industry

“…In spite of the assertion that the consumption of a high amount of saturated fats from palm oil is linked with cardiovascular diseases, studies revealed that there is no concrete evidence associating palm oil intake with the risk of heart disease or the negative impact on children's health [72,73]. Furthermore, the link between the dietary intake of palm oil and obesity, in comparison with other vegetable oils, is not supported by adequate evidence [74][75][76]. There is also no scientific proof to validate the association between palm oil intake and the incidence of cancer [77].…”