The Role of Visfatin (Adipocytokine) Biomarker in Oral Health and Diseases among Nonobese Indian Population: A Proteomic Assay

Coutinho, Amita; Reddy, Neethu; Chatterjee, Anirban; Khan, Mahamad Irfanulla

doi:10.1055/s-0041-1728690

Cited by 6 publications

(11 citation statements)

References 32 publications

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“…After reading the abstract of the remaining 48 studies, 37 of them were extracted as initially eligible studies. By examining full texts, 22 articles were finally included in the meta-analysis ( Pradeep et al, 2011 ; Raghavendra et al, 2012 ; Xu et al, 2023 ; Pradeep et al, 2012 ; Tabari et al, 2014 ; Abolfazli et al, 2015 ; Ghallab, Amr & Shaker, 2015 ; Mohamed et al, 2015 ; Tabari et al, 2015 ; Özcan et al, 2016a , 2016b , 2017 ; Tabari et al, 2018 ; Bahammam & Attia, 2018 ; Mopidevi et al, 2019 ; Rezaei et al, 2019 ; Çetiner et al, 2019 ; Paul et al, 2020 ; Saljoughi, Nasri & Bayani, 2020 ; Saseendran et al, 2021 ; Coutinho et al, 2021 ; Bengi et al, 2024 ). The reasons for inclusion in the full-text selection are shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Association between visfatin and periodontitis: a systematic review and meta-analysis

Li,

Xin,

Xie

et al. 2024

PeerJ

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Background Periodontitis is a chronic inflammatory disease caused by bacterial infection in the periodontal support tissue. Visfatin, a hormone secreted mainly by adipocytes and macrophages, plays an important role in immune regulation and defense. Although studies have indicated that patients with periodontitis have significantly high serum and gingival crevicular fluid levels of visfatin, the relationship between this adipocytokine and periodontal disease remains unclear. Aim The aim of this study was to systematically evaluate the association between visfatin levels and periodontitis. Methods The PubMed, Web of Science, ScienceDirect, EBSCO, and Wiley Online Library databases were searched for potential studies, using “periodontitis” and “visfatin” as the keywords in the title and abstract search fields. Standardized mean difference (SMD) values with corresponding 95% confidence intervals (CIs) were determined from the results of this meta-analysis. Results In total, 22 articles involving 456 patients with periodontitis and 394 healthy individuals (controls) were included in the meta-analysis. Visfatin levels were significantly higher in the patients with periodontitis than in the healthy individuals (SMD: 3.82, 95% CI [3.01–4.63]). Moreover, the visfatin levels were significantly lowered after periodontitis treatment (SMD: −2.29, 95% CI [−3.33 to −1.26]). Conclusion This first-ever meta-analysis comparing visfatin levels between patients with periodontitis and healthy individuals suggests that this adipocytokine can be a diagnostic and therapeutic biomarker for periodontal disease.

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Section: Resultsmentioning

confidence: 99%

Association between visfatin and periodontitis: a systematic review and meta-analysis

Li,

Xin,

Xie

et al. 2024

PeerJ

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“…There was a positive correlation between visfatin levels in GCF and periodontal indexes (PD, AL, PLI, BI), consistent with the findings of other studies [ 23 , 24 , 32 ]. GCF and serum visfatin levels increased in both periodontitis and gingivitis patients compared to healthy controls, and the mean salivary visfatin levels also increased with the severity of periodontal tissue destruction [ 33 , 34 ]. Non-surgical periodontal treatment significantly improved the periodontal conditions of patients with periodontitis, leading to reduced PD, increased clinical attachment levels, and decreased release of inflammatory mediators from local tissues.…”

Section: Discussionmentioning

confidence: 99%

Expression of visfatin in gingival crevicular fluid and gingival tissues in different periodontal conditions: a cross-sectional study

Xiao,

Chen,

Mao

et al. 2024

BMC Oral Health

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Background Studies have shown that visfatin is an inflammatory factor closely related to periodontitis. We examined the levels of visfatin in gingival crevicular fluid (GCF) and gingival tissues under different periodontal conditions, in order to provide more theoretical basis for exploring the role of visfatin in the pathogenesis of periodontitis. Methods We enrolled 87 subjects, with 43 in the chronic periodontitis (CP) group, 21 in the chronic gingivitis (CG) group, and 23 in the periodontal health (PH) group. Periodontal indexes (PD, AL, PLI, and BI) were recorded. GCF samples were collected for visfatin quantification, and gingival tissues were assessed via immunohistochemical staining. Results Visfatin levels in GCF decreased sequentially from CP to CG and PH groups, with statistically significant differences (P < 0.05). The CP group exhibited the highest visfatin levels, while the PH group had the lowest. Gingival tissues showed a similar trend, with significant differences between groups (P < 0.001). Periodontal indexes were positively correlated with visfatin levels in both GCF and gingival tissues (P < 0.001). A strong positive correlation was observed between visfatin levels in GCF and gingival tissues (rs = 0.772, P < 0.001). Conclusion Greater periodontal destruction corresponded to higher visfatin levels in GCF and gingival tissues, indicating their potential collaboration in damaging periodontal tissues. Visfatin emerges as a promising biomarker for periodontitis and may play a role in its pathogenesis.

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“…After screening the title and abstract of these studies by two authors independently, 58 studies that did not meet the inclusion criteria were excluded and the full text of the remaining 33 studies was examined. Finally, sixteen studies [16,17,19,[24][25][26][27][28][29][30][31][32][33][34][35][36] were included in the meta-analysis. Seventeen studies that were impossible to include in the meta-analysis are presented in S2 Table with details and reasons [14,15,18,[37][38][39][40][41][42][43][44][45][46][47][48][49][50] and can be considered as qualitative data.…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

“…Seventeen studies that were impossible to include in the meta-analysis are presented in S2 Table with details and reasons [14,15,18,[37][38][39][40][41][42][43][44][45][46][47][48][49][50] and can be considered as qualitative data. In most studies, periodontal diseases were classified based on the 1999 classification for periodontal diseases and conditions [51] and 4 studies [34,[47][48][49] based on the 2018 classification [52]. One of the studies analyzed biopsy samples, one studied saliva, one studied saliva and serum without providing quantitative data, and one studied GCF.…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

Periodontal disease and visfatin level: A systematic review and meta-analysis

Bayani,

Heidari,

Almasi-Hashiani

2023

PLoS ONE

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Visfatin is considered an inflammatory biomarker in periodontal disease (PD). In this meta-analysis, we aimed to evaluate the relationship between Visfatin biomarker level with PD. In this study, Medline, Scopus, Web of Science, and Google Scholar were searched. We included studies that examined visfatin levels in samples from healthy people and periodontal disease until March 2023. The quality of the selected articles was evaluated using the Newcastle-Ottawa assessment scale. Depending on heterogeneity of studies, random-effects or fixed-effect models were used to pool results and report the standardized mean difference (SMD). After screening the retrieved papers, the related data were extracted. A total of 159 studies were identified, and 16 studies were included in the meta-analysis. In 9 studies, the SMD of visfatin level of gingival crevicular fluid (GCF) in patients with chronic periodontitis (CP) and healthy individuals was 4.32 (p<0.001). In 6 studies, the SMD of salivary visfatin level in patients with CP and healthy individuals was 2.95 (p = 0.004). In addition, in five studies, the SMD of serum visfatin level in patients with CP and healthy individuals was 7.87 (p<0.001). Therefore, Visfatin levels in serum, saliva, and GCF of patients with CP were increased in comparison to healthy individuals. Comparison of visfatin levels in saliva of gingivitis patients and healthy individuals showed a significant increase of visfatin in gingivitis patients (SMD:0.57, P = 0.018), but no significant difference was observed in the mean GCF visfatin level of gingivitis patients and healthy individuals (SMD:2.60, P = 0.090). In addition, the results suggested that there is no difference between gingivitis cases compared to CP patients (SMD:3.59, P = 0.217). Visfatin levels in GCF, serum, and saliva have the potential to be used as a diagnostic biomarker of periodontitis.

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The Role of Visfatin (Adipocytokine) Biomarker in Oral Health and Diseases among Nonobese Indian Population: A Proteomic Assay

Cited by 6 publications

References 32 publications

Association between visfatin and periodontitis: a systematic review and meta-analysis

Association between visfatin and periodontitis: a systematic review and meta-analysis

Expression of visfatin in gingival crevicular fluid and gingival tissues in different periodontal conditions: a cross-sectional study

Periodontal disease and visfatin level: A systematic review and meta-analysis

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